路嘉宏


助理教授

 

學歷 | 主講科目 | 學術研究 | 科研論著 | 聯絡方法


學歷

  • 中南大學湘雅醫學院 本科
  • 中南大學醫學遺傳學國家重點實驗室 碩士
  • 香港浸會大學中醫藥學院 博士

主講科目


學術研究

研究興趣

1) 神經藥理學以及建立分子靶標篩選系統發現具有抗神經退行性病變活性的中藥單體及提取物

2) 神經系統自噬:分子機制以及藥物靶點研究

路嘉宏博士獲得博士學位後在美國伊坎-西奈山醫學院接受了三年的博士後培訓,然後加入澳門大學成為助理教授。路博士是神經生物學,細胞生物學和藥理學專家,他的主要研究興趣在於神經退行性疾病的機制研究和藥物開發,主要的策略是調控神經細胞的自噬水準。路博士將聯合生物化學,分子細胞生物學以及神經生物學的研究方法,應用細胞,果蠅和轉基因小鼠等多層面的模型來篩選和評估天然小分子自噬調節劑在神經退行性疾病中的應用潛力。路博士在多個高水準學術雜誌如 Nature Communications, Autophagy, Chembiochem, Neurobiology of ageing 發表學術論文:

招收博士和碩士研究生,歡迎有興趣投身神經自噬研究和藥物開發的同學與路博士聯繫jiahonglu@umac.mo

 


科研論著

 

  1. Chen L.L., Song J.X., Lu J.H., Yuan Z.W., Liu L.F., Duriarajan S.S.K., Li M*. (2014) “Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway”, J. Neuroimmune. Pharma. 2014, DOI: 10.1007/s11481-014-9522-8. [Epub ahead of print]
    Impact factor: 3.802
  2. Han L.F.*, Wang W.*, Lu J.H.*, Li F., Kong F.F., Zhu Y.P., Dong Z., Zhu J.L., Wen S., Zhou Q., Chen P., Ahmad S. and Sun J.. (2014). “AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity inagainst a murine melanoma pulmonary metastasis model”.  Cancer letters. 2014 Nov 28;354(2):398-406.  *co-first author
    Impact factor:  4.258
  3. Chua K.K., Chen L.L., Liu L.F., Duriarajan S.S.K., Lu J.H. and Li M.* (2014) “The Efficacy of Classical Chinese Medicine Formula Di-tan Decoction for Alzheimer’s disease” Chin. J. Integra. Med. (In press)
    Impact factor: 1.059
  4. Lu J.H.*, He L.Q.*, Behrends C., Araki M., Arak K.,Wang Q.J., Catanzaro J.M., Friedman S. L., Zong W.X., Fiel M. I., Li M.and Yue Z.Y.* (2014) “NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity”. Nature Communications. 2014; 5:3920, DOI: 10.1038/ncomms4920.
    Impact factor:  10.051
  5. Song J.X., Lu J.H., Liu L.F., Chen L. L., Durairajan S.S.K., Yue Z.Y., Zhang H.Q*. & Li M. * (2013) “HMGB1 is involved in autophagy inhibition caused by alpha-synuclein overexpression: a process modulated by the natural autophagy inducer Corynoxine B” Autophagy. 2014 Jan;10(1):144-54. DOI: 10.4161/auto.26751.
    Impact factor: 12.042
  6. Lu J.H., Tan J.Q., Durairajan S.S.K., Liu LF, Zhang Z.H., Ma L., Shen H.M., Chan H.Y.* and Li M.* (2012) “Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.” Autophagy. 2012; 8(1):98-108. (Erratum in Autophagy. 2012; 8(5): 864-866.)
    Impact factor: 12.042
  7. Lu J.H., Song J.X., Durairajan S.S.K., Liu L.F., and Li M.* (2012) “Chinese herbal medicinal Corynoxine B promotes the clearance of pathogenic protein aggregations associated with Parkinson’s disease via inducing autophagy”. ACTA Biophysica Sinica. (Suppl.1)2012, 28(7):21.
  8. Lu J.H., Ardah M.T., Duriarajan S.S.K., Liu L.F., Xie L.X., Fong W.F., Hasan M.Y., Huang J.D., El-Agnaf O.M.A.* and Li M.* (2011). “Baicalein Inhibits Formation of Alpha-synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerization”.  ChemBioChem. 2011,12:615-624.
    Impact factor: 3.944
  9. He L.Q., Lu J.H., Yue Z.Y.* (2013) “Autophagy in ageing and ageing-associated diseases” (Invited Review). Acta Pharmacol Sin. 2013; 34: 605-11.
    Impact factor: 2.35
  10. Durairajan S.S.K., Liu L.F., Lu J.H., Chen L.L., Yuan Q.J., Chung S.K., Huang L., Li X.S., Huang J.D.* and Li M.* (2012) “Berberine Ameliorates Beta-amyloid Pathology, Gliosis and Cognitive Impairment in an Alzheimer's Disease Transgenic Mouse Model”. Neurobiol. Aging 2012, 33: 2903-2919.
    Impact factor: 6.16
  11. Liu L.F., Durairajan S.S.K., Lu J.H., Koo I. and Li M.* (2012) “In Vitro Screening on Amyloid Precursor Protein Modulation of Plants used in Ayurvedic and Traditional Chinese Medicine for Memory Improvement”. J. Ethnopharmacol. 2012, 141(2): 754-760.
    Impact factor: 2.755
  12. Man S.C., Chan K.W., Lu J.H., Durairajan S.S.K., Liu L.F. and Li M.* (2012) “Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia”. Evid-Based Compl. Alt. Med. (DOI:10.1155/ ecam/2012/426215)
    Impact factor: 1.722
  13. Duriarajan S.S.K., Liu L.F., Lu J.H., Koo I., Maruyama K., Chung S.K., Huang J.D.* and Li M.* (2011). “Stimulation of Non-amyloidogenic Processing of Amyloid Precursor Protein by Cryptotanshinone Involves Activation and Translocation of ADAM-10 and PKC-alpha”. J. Alzheimer’s Dis. 2011, 25: 245-262.
    Impact factor: 3.745
  14. Kum W.F., Durairajan S.S.K., Bian ZX, Man S.C., Lam Y.C., Xie L.X, Lu J.H.,Wang Y., Huang X.Z., Li M.* (2011). “Treatment of Idiopathic Parkinson’s Disease with Traditional Chinese Herbal Medicine: a Randomized Placebo-controlled Pilot Clinical Study”. Evid-Based Compl. Alt. Med.2011; 2011: 724353.
    Impact factor:: 4.774
  15. Duriarajan S.S.K., Liu L.F., Lu J.H., Koo I., Chung S.K., Maruyama K., Huang J.D. and Li M.* (2011) “Beberine Inhibits Abeta Production, Plaque Formation, Gliosis and Cognitive Deterioration in a Transgenic Mouse Model of Alzheimer’s disease”.  Neurodegener. Dis. 2011; 8 (Suppl.1):1 (DOI:10.1159/000327701) 
    Impact factor: 3.056
  16. Xie L. X., Durairajan S.S.K., Lu J.H., Liu C.L., Kum W.F., Wang Y., Koo I., Wu W.K., Han D., Lao F., Huang J.D. and Li  M.* (2010). “The Effect of Salvianolic acid B Combined with Laminar Shear Stress on TNF-alpha Stimulated Adhesion Molecule Expression in Human Aortic Endothelial Cells”. Clin. Hemorheol Microcirc. 44: 245-258.
  17. Zhu F.Z., Lu J.H., Liu X. P., Tan J.Q., Zhang Z.L., Chi J.W., Wu, L.Q., Liang D.S., Pan Q., Long Z.G., Dai H.P., Xia J.H., Zhang Z.H., Xia K.* (2009). Expression Profiling and Localization Analysis of Parkinson’s disease Associated Protein LRRK2. Chin. J. Biochem. Mol. Biol. 25: 1137-1142
  18. Chan W.S †., Durairajan S.S.K.†, Lu J.H., Xie L. X., Wang Y., Kum W.F., Koo I.,Yung K.K.L. and Li M.* (2009). “The Neuroprotective Effects of Astragaloside IV (AS-IV) in 6-OHDA-treated Nigral Primary Cell Culture”. Neurochem. Int. 55:414-422. († Co-first author).
    Impact factor: 3.541
  19. Kum W. F., Gao J., Kumar D.S.S., Man S.C., Xie L.X., Lu J.H., Fong W.L. and Li M.* (2009) “Risk Factors in Development of Motor Complications in Chinese patients with Idiopathic Parkinson’s Disease”. J. Clin. Neurosci. 2009, 16: 1034-1037.
    Impact factor: 1.17
  20. Lam Y. C., Kum W.F., Lu J.H., Durairajan S.S.D., Man S. C., Xu M., Zhang X. F., Huang X.Z. and Li M.* (2008) “Efficacy and Safety of Acupuncture for Idiopathic Parkinson’s disease: A Systematic Review”. J. Altern. Complem. Med. 2008, 14:663-671.
    Impact factor: 1.628
  21. Xie L.X., Durairajan S.S.D., Liu C.L., Lu J.H., Kum W. F., Huang J. D., Liao F.L., Li M. *(2008) “The Effect of Salvianolic Acid B on TNF-alpha-stimulated Adhesion Molecule Expression under Flow Condition in Endothelial Cells”.Biorheology. 2008; 45: Suppl.42-43.
    Impact factor: 2.273
  22. Man S.C., Durairajan S.S.D., Kum W. F., Lu J.H., Huang J.D., Cheng C.F., Chung V., Xu M. and Li M.* (2008) “Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer’s Disease”. J. Alzheimer’s Dis. 2008, 14: 209-223.
    Impact factor: 5.101

論著與章節

  • Jiahong Lu and Zhenyu Yue (2014) Book Chapter, “The Role of Autophagy in Parkinson’s disease”, in Book “ Autophagy- Biology and Diseases” (In press)

專利

  • Li M., Lu J.H., Durairajan S.S.K., Liu L.F. “Autophagy Inducing Compounds and the Uses Thereof” U.S. Non-provisional Patent Application No.US 13/420,628, 2013.
  • Li M., Durairajan S.S.K., Liu L.F., Lu J.H. “Berberine Alkaloid as a Medicament for Prophylaxis and Treatment of Alzheimer's Disease” U.S. Provisional Patent Application No.61/609917, 2013.


專業資格

紐約科學院  會員
美國神經科學會 會員

 


聯絡方法

中國澳門氹仔大學大馬路
澳門大學中華醫藥研究院N22-7015
電子郵件: jiahonglu@umac.mo
Telephone: (853) 8822-4508