Ligen Lin  林理根
Assistant Professor

Academic Qualifications | Teaching | Research | Selected Publications | Qualifications | Contact Details


Academic Qualifications


Teaching


Research

Research Interests


Selected Publications

Study on obesity and diabetes: (*co-first author)

1.        Ma, X.-J.*, Lin, L.-G.*, Qin, G.-J., Lu, X, Fiorotto, M., Dixit, V.D., Sun, Y.-X. (2011). Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging. PlosOne, 6(1), e16391. * Equal contribution. (IF=4.092)

2.        Lin, L.-G., Saha, P.K., Ma, X.-J., Henshaw, I.O., Shao, L.-J., Chang, B.H.J., Bura,s E.D., Tong, Q., Chan, L., McGuinness, O.P., and Sun, Y.-X. (2011) Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell, 10, 996-1010. (IF=6.262)

3.        Lin, L.-G., Pang, W.-J., Chen, K.-Y., Wang, F., Gengler, J., Sun, Y.-X. and Tong, Q. (2012) Adipocyte expression of PU.1 transcription factor causes insulin resistance through up-regulation of ROS production and inflammatory cytokine gene expression. American Journal of Physiology-Endocrinology and Metabolism, 302, E1550-E1559. (IF=4.746)

4.        Lin, L.-G., Sun, Y.-X. (2012) Thermogenic characterization of ghrelin receptor null mice. Method in Enzymology, 514, 355-370. (IF=2.042)

5.        Ma, X.-J., Lin, Y.-Z., Lin, L.-G., Qin, G.-J., Pereira, F.A., Haymond, M.W., Butte, N.F., Sun, Y.-X. (2012) Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice. American Journal of Physiology-Endocrinology and Metabolism, 303, E422-E431. (IF=4.746)

Study on natural products chemistry:

  1. Lin, L.-G.; Zhong, Q.-X.; Cheng, T.-Y.; Tang, C.-P.; Ke, C.-Q.; Lin, G.; Ye, Y. (2006). Stemoninines from the Roots of Stemona tuberosa Journal of Natural Products, 69, 1051-1054. (IF=3.128)
  2. Yang, X.-Z.; Lin, L.-G.; Tang, C.-P.; Liu, Y.-Q.; Ye, Y. (2007). Non-alkaloid Constituents from Stemona japonica, Helv. Chim. Acta. 90, 318-325. (IF=1.478)
  3. Lin, L.-G.; Tang, C.-P.; Xu, R.-S.; Ye, Y. (2007). Cochinchistemonine, an unprecedented skeleton alkaloid from Stemona cochinchinensis, Tetrahedron Letters. 48, 1559-1561. (IF=2.683)
  4. Lin, L.-G.; Pham, H.-D.; Tang, C.-P.; Ke, C.-Q.; Yang, X.-Z.; Ye, Y. (2007). Alkaloids from the roots of Stemona cochinchinensis, Helv. Chim. Acta. 90, 2167-2175. (IF=1.478)
  5. Lin, L.-G.; Yang, X.-Z.; Tang, C.-P.; Ke, C.-Q.; Zhang, J.-B.; Ye, Y. (2008). Antibacterial stilbenoids from the roots of Stemona tuberosa, Phytochemistry. 69, 457-463. (IF=3.351)
  6. Lin, L.-G.; Tang, C.-P.; Ke, C.-Q.; Zhang, Y.; Ye, Y. (2008). Terpenoids from stems of Cipadessa baccifera, Journal of Natural Products. 71, 628-632. (IF=3..128)
  7. Lin, L.-G.; Cheng, T.-Y.; Tang, C.-P.; Ke, C.-Q.; Rudd, J. A.; Lin, G.; Ye, Y. (2008). Anti-tussive alkaloids from roots of Stemona tuberosa, Journal of Natural Products. 71, 1107-1110. (IF=3.128)
  8. Dien, P.-H.; Lin, L.-G.; Tang, C.-P.; Ke, C.-Q.; Ye, Y. (2008). Bis-benzopyrans and alkaloids from the roots of Stemaona cochinchinensis, Natural Product Research. 22, 915-920. (IF=1.009)
  9. Lin, L.-G.; Xie, H.; Li, H.-L.; Tong, L.-J.; Tang, C.-P.; Ke, C.-Q.; Lin, L.-P.; Geng, M.-Y.; Jiang, H.-L.; Zhao, W.-M.; Ding, J.; Ye, Y. (2008). Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening, Journal of Medicinal Chemistry. 71, 628-632. (IF=5.248)
  10. Lin, L.-G., Leung, H. P.-H.; Zhu, J.-Y.; Tang, C.-P.; Ke, C.-Q.; Rudd, J. A.; Lin, G.; Ye, Y. (2008). Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity, Tetrahedron. 64, 10155-10161. (IF=3.025)
  11. Yang, X.-Z.; Lin, L.-G.; Tang, C.-P.; Ke, C.-Q..; Ye, Y. (2008). Non-alkaloid Constituents from Stemona sessilifolia, Natural Product Research and Development. 20, 56-59.
  12. Li, G.-L., Gui, S.-Q., Chen, S.-H., Ge, X.-R., Lin, L-G., and Ye, Y. (2008). Apoptosis induction effect of Pinellia extract fraction on cell lines of cervical cancer cultured in vitro, China Journal of Traditional Chinese Medicine and Pharmacy. 23, 447–449.
  13. Peng. S.-Y., Shi, T., Wang, Y.-Z., Lin, L-G., Yang, Y.-M., Jiang, H.-L., and Ye, Y. (2009). Rapid structural determination of alkaloids in a crude extract of Stemona saxorum by high-performance liquid chromatography/electrospray ionization coupled with tandem mass spectrometry, Rapid Communications in Mass Spectrometry. 23, 3621–3631. (IF=2.79)
  14. Li, G.-L., Gui, S.-Q., Xia, Q., Chen, S.-H., Ge, X.-R., Lin, L-G., and Ye, Y. (2010). Effect of Pinellia extract on proliferation of cervical cancer cell lines and associated mechanism, Chinese Journal of Histochemistry and Cytochemistry. 19, 53–57.
  15. Li, G.-L., Gui, S.-Q., Xia, Q., Chen, S.-H., Ge, X.-R., Lin, L-G., and Ye, Y. (2010). Mechanisms of apoptosis induction effect of Pinellia pedatisecta Schott extract on CaSKi cell lines of cervical cancer cultured in vitro, China Journal of Traditional Chinese Medicine and Pharmacy. 25, 449–452.
  16. Li, G.-L., Gui, S.-Q., Wang, L., Lin, L-G., and Ye, Y. (2010). Effect of Pinellia extract on Hela cell line in vitro and associated mechanism, Chinese Journal of Integrated Traditional and Western Medicine. 30, 243–246.

Patents

 

  1. Ye, Y., Lin, G., Lin, L-G., Anthony, J.R., Li, X.-Q., Tang, C.-P., Ke, C.-Q. Use of alkaloids compounds in preparingof medicament for treating cough. CN 200710045498.3. 2009.
  2. Ye, Y., Lin, G., Lin, L-G., Anthony, J., Li, X.-Q., Tang, C.-P., Ke, C.-Q. Total alkaloid extract, and extraction method thereof and use in preparing medicament for treating cough. CN 200710046888.2. 2009.
  3. Ye, Y., Lin, G., Lin, L-G., Anthony, J.R., Li, X.-Q., Tang, C.-P., Ke, C.-Q. The use of alkaloids in preparation of medicament for treating cough. WO 2009//030116. 2009.

 


Qualifications


Contact Details

Institute of Chinese Medical Sciences
University of Macau
Macao, China

Room: 6043, N22
Telephone: (853) 8822-8041
Fax: (853) 28841358
E-mail:LigenL@umac.mo