Chung-Hang LEUNG 梁重恒
Professor

Academic Qualifications | Teaching | Research | Selected Publications |Professional Contributions

 | Contact Details


Academic Qualifications

 

 


Teaching

Undergraduate Courses

  1. From Cells to Organisms
  2. Biochemistry and Molecular Biology I
  3. Biochemistry and Molecular Biology II
  4. Biochemistry and Molecular Biology II – Laboratory
  5. Wonders in Life Science and Health: Biomedical Science
  6. Final Year Projects

 

Postgraduate Courses

  1. University Teaching I
  2. Drug Targets and Drug Discovery

 


Research

Research Interests

1. Drug discovery

         Discovery of natural products and metal-based compounds for important molecular targets with special emphasis on modulators of protein-protein interactions and gene transcription.

2. Luminescent sensing methods

         Detection of enzyme activities for high-throughput drug screening

         Detection of hazardous substances such as metal ions and toxins for quality control and food safety

Group Pages

We are now looking for postgraduate students and research assistants who wish to participate in our research projects on drug discovery and sensing of biomolecules. For further information, please contact Dr. Leung at duncanleung@umac.mo

  


Selected publications

  1. Liu LJ, Wang WH, Huang SY, Hong YJ, Li GD, Lin S, Tian JL, Cai ZW,* Wang HMD,* Ma DL,* Leung CH (Corresponding author).* (2017) Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(III) metal-based compound. Chem Sci 8, 4756.
    Inside back cover
    Impact factor: 8.668
  2. Ko CN, Yang C, Lin S, Li SN, Dong ZZ, Liu JB,* Lee SMY,* Leung CH (Corresponding author),* Ma DL.* (2017) A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation. Biosens Bioelectron 94, 575.
    Impact factor: 7.78
  3. Kang TS, Wang WH, Zhong HJ, Dong ZZ, Huang Q, Mok SWF, Leung CH (Corresponding author),* Wong VKW,* Ma DL.* (2017) An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB. Cancer Lett 396, 76.
    Impact factor: 6.375
  4. Dong ZZ, Lu LH, Wang WH, Li GD, Kang TS, Han QB, Leung CH (Corresponding author),* Ma DL.* (2017) Luminescent detection of nicking endonuclease Nb.BsmI activity by using a G-quadruplex-selective iridium(III) complex in aqueous solution. Sensor Actuat B-Chem 246, 826.
    Impact factor: 5.401
  5. Yang C, Wang WH, Liang JX, Li GD, Vellaisamy K, Wong CY, Ma DL,* Leung CH (Corresponding author).* (2017) A rhodium(III)-based inhibitor of lysine-specific histone demethylase 1 as an epigenetic modulator in prostate cancer cells. J Med Chem 60, 2597.
    Impact factor: 6.259
  6. Wang WH, Yang C, Lin S, Vellaisamy K, Li GD, Tan WH,* Leung CH (Corresponding author),* Ma DL.* (2017) First synthesis of an oridonin-conjugated iridium(III) complex for the intracellular tracking of NF-κB in living cells. Chem Eur J 23, 4929.
    Impact factor: 5.137
  7. Liu CF, Yang C, Lu L, Wang WH, Tan WH,* Leung CH (Corresponding author),* Ma DL.* (2017) Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells. Chem Commun 53, 2822.
    Back cover
    Impact factor: 6.319
  8. Dong ZZ, Lu L, Ko CN, Yang C, Li S, Lee MY, Leung CH (Corresponding author),* Ma DL.* (2017) A MnO2 nanosheet-assisted GSH detection platform by using iridium(III) complex as a switch-on luminescent probe. Nanoscale 9, 4631.
    Inside front cover
    Impact factor: 7.367
  9. Zhong HJ,* Wang WH, Kang TS, Yan H, Yang YL, Xu LP, Wang YQ, Ma DL,* Leung CH (Corresponding author).* (2016) A rhodium(III) complex as an inhibitor of neural precursor cell expressed, developmentally down-regulated 8-activating enzyme with in vivo activity against inflammatory bowel disease. J Med Chem 60, 497.
    Impact factor: 6.259
  10. Ma DL,* Lin S, Wang WH, Yang C, Leung CH (Corresponding author).* (2017) Luminescent chemosensors by using cyclometalated iridium(III) complexes and their applications. Chem Sci 8, 878.
    Impact factor: 8.668
  11. Lin S, Lu L, Kang TS, Mergny JL, Leung CH (Corresponding author),* Ma DL.* (2016) The interaction of an iridium(III) complex with G-quadruplex DNA and its application in luminescent switch-on detection of Siglec-5. Anal Chem 88, 10290.
    Impact factor: 6.32
  12. Yang C, Wang WH, Chen LM, Liang JX, Lin S, Lee SMY, Ma DL,* Leung CH (Corresponding author).* (2016) Discovery of a VHL and HIF1α interaction inhibitor with in vivo angiogenic activity by structure-based virtual screening. Chem Commun 52, 12837.
    Impact factor: 6.319
  13. Liu LJ, Wang WH, Zhong Z, Lin S, Lu L, Wang YT, Ma DL,* Leung CH (Corresponding author).* (2016) Inhibition of TLR1/2 dimerization by enantiomers of metal complexes. Chem Commun 52, 12278.
    Front cover
    Impact factor: 6.319
  14. Lin S, Kang TS, Lu L, Wang WH, Ma DL,* Leung CH (Corresponding author).* (2016) A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity. Biosens Bioelectron 86, 849.
    Impact factor: 7.78
  15. Ma DL,* Wang M, Liu CF, Miao XM, Kang TS, Leung CH (Corresponding author).* (2016) Metal complexes for the detection of disease-related protein biomarkers. Coord Chem Rev 324, 90.
    Impact factor: 13.324
  16. Miao XM, Wang WH, Kang TS, Liu JB, Shiu KK, Leung CH, Ma DL.* (2016) Ultrasensitive electrochemical detection of miRNA-21 by using an iridium(III) complex as catalyst. Biosens Bioelectron 86, 454.
    Impact factor: 7.78
  17. Lu L,* Mao ZF, Kang TS, Leung CH (Corresponding author),* Ma DL.* (2016) A versatile nanomachine for the sensitive detection of platelet-derived growth factor-BB utilizing a G-quadruplex-selective iridium(III) complex. Biosens Bioelectron 85, 300.
    Impact factor: 7.78
  18. Leung CH (Corresponding author),* Liu LJ, Leung KH, Ma DL.* (2016) Epigenetic modulation by inorganic metal complexes. Coord Chem Rev 319, 25.
    Impact factor: 13.324
  19. Kang TS, Mao ZF, Ng CT, Wang M, Wang WH, Wang CM, Lee SMY, Wang YT, Leung CH (Corresponding author),* Ma DL.* (2016) Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α. J Med Chem 59, 4026.
    Impact factor: 6.259
  20. Zhong HJ, Lee BR, Boyle JW, Wang WH, Ma DL,* Chan PWH,* Leung CH (Corresponding author).* (2016) Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction. Chem Commun 52, 5788.
    Front cover
    Impact factor: 6.319
  21. Liu LJ, He BY, Miles JA, Wang WH, Mao ZF, Che WI, Lu JJ, Chen XP, Wilson AJ, Ma DL,* Leung CH (Corresponding author).* (2016) Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium (III) compounds. Oncotarget 7, 13965.
    Impact factor: 5.168
  22. Zhong HJ, Lu L, Wong CL-C , Peng C, Yan SC, Ma DL,* Cai ZW,* Wang HMD* and Leung CH (Corresponding author).* (2015) An iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent. Chem Sci 6, 5400.
    Impact factor: 8.668
  23. Liu LJ, Lu L, Zhong HJ, He BY, Kwong D, Ma DL,* Leung CH (Corresponding author).* (2015) An Iridium() complex inhibits JMJD2 activities and acts as a potential epigenetic modulator. J Med Chem 16, 6697.
    Impact factor: 6.259
  24. Wang WH, Mao ZF, Wang M, Liu LJ, Kwong DWJ, Leung CH (Corresponding author),* Ma DL.* (2016) A long lifetime luminescent iridium(III) complex chemosensor for selective switch-on detection of Al3+ ions. Chem Commun 52, 3611.
    Front cover
    Impact factor: 6.319
  25. Lin S, Yang C, Mao Z, He BY, Wang YT, Leung CH (Corresponding author),* Ma DL.* (2016) A G-pentaplex-based assay for Cs+ ions in aqueous solution using a luminescent Ir(III) complex. Biosens Bioelectron 77, 609.
    Impact factor: 7.78
  26. Leung KH, He BY, Yang C, Leung CH (Corresponding author),* Wang HM,* Ma DL.* (2015) Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation. ACS Appl Mater Interfaces 7, 24046.
    Impact factor: 7.504
  27. Lin S, He B, Yang C, Leung CH (Corresponding author),* Mergny JL,* Ma DL.* (2015) Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium(III) complex. Chem Commun 51, 16033.
    Front cover
    Impact factor: 6.319
  28. Zhong Z, Liu LJ, Dong ZQ, Lu L, Wang M, Leung CH (Corresponding author),* Ma DL,* Wang YT.* (2015) Structure-based discovery of an immunomodulatory inhibitor of TLR1-TLR2 heterodimerization from a natural product-like database. Chem Commun 51, 11178.
    Impact factor: 6.319
  29. Lu L, Wang M, Liu LJ, Wong CY, Leung CH (Corresponding author),* Ma DL.* (2015) A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe. Chem Commun 49, 9953.
    Impact factor:
    6.319
  30. Leung CH (Corresponding author),* Liu LJ, Lu L, He B, Kwong DWJ, Wong CY,* Ma DL.* (2015) A metal-based tumour necrosis factor-alpha converting enzyme inhibitor. Chem Commun 51, 3973.
    Front cover
    Impact factor: 6.319
  31. Leung KH, He HZ, Zhong HJ, Lin S, Wang YT, Ma DL,* Leung CH (Corresponding author).* (2015) Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe. Chem Sci 6, 2166.
    Front cover
    Impact factor: 8.668
  32. Ma DL,* Chan DSH, Leung CH (Corresponding author).* (2014) Group 9 organometallic compounds for therapeutic and bioanalytical applications. Acc Chem Res 47, 3614.
    Impact factor: 20.268
  33. Lu L, Chan DSH, Kwong DWJ, He HZ,* Leung CH (Corresponding author),* Ma DL.* (2014) Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe. Chem Sci 5, 4561.
    Inside front cover
    Impact factor: 8.668
  34. Ma DL,* Chan DSH, Wei G, Zhong HJ, Yang H, Leung LT, Gullen EA, Chiu P,* Cheng YC,* Leung CH (Corresponding author).*  (2014) Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library. Chem Commun 50, 13885.
    Inside front cover
    Impact factor: 6.319
  35. Ma DL,* Liu LJ, Leung KH, Chen YT, Zhong HJ, Chan DSH, Wang HMD,* Leung CH (Corresponding author).* (2014) Antagonising STAT3 dimerization with a rhodium(III) complex. Angew Chem Int Ed 53, 9178.
    Back cover
    Selected as very important paper
    Highlighted by SciBX, Nature Publishing Group, 2014, 7(26)

    Impact factor: 11.994
  36. Liu LJ, Leung KH, Chan DSH, Wang YT, Ma DL,* Leung CH (Corresponding author).* (2014) Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell Death Dis 5, e1293.
    Impact factor: 5.965
  37. He HZ, Leung KH, Wang W, Chan DSH, Leung CH, Ma DL.* (2014) Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe. Chem Commun 50, 5313.
    Inside front cover
    Impact factor: 6.319
  38. Leung CH (Corresponding author),* He HZ, Liu LJ, Wang M, Chan DSH, Ma DL.* (2013) Metal complexes as inhibitors of transcription factor activity. Coord Chem Rev 257, 3139.
    Impact factor: 13.324
  39. Leung CH (Corresponding author),* Zhong HJ, Chan DSH, Ma DL.* (2013) Bioactive iridium and rhodium complexes as therapeutic agents. Coord Chem Rev 257, 1764.
    Impact factor: 13.324
  40. Leung KH, He HZ, Ma VPY, Zhong HJ, Chan DSH, Zhou J, Mergny JL, Leung CH (Corresponding author),* Ma DL.* (2013) Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe. Chem Commun 49, 5630.
    Front cover
    Impact factor: 6.319
  41. Ma DL,* Chan DSH, Leung CH (Corresponding author).* (2013) Drug repositioning by structure-based virtual screening. Chem Soc Rev 42, 2130.
    Impact factor: 38.618
  42. Leung CH (Corresponding author),* Zhong HJ, Yang H, Cheng Z, Chan DSH, Ma VPY, Abagyan R, Wong CY, Ma DL.* (2012) A metal-based inhibitor of tumor-necrosis factor-alpha. Angew Chem Int Ed 51, 9010.
    Frontispiece
    Impact factor: 11.994
  43. Ma DL,* Xu T, Chan DSH, Man BYW, Fong WF, Leung CH (Corresponding author).* (2011) A Highly Selective, Label-Free, Homogenous Luminescent Switch-On Probe for the Detection of Nanomolar Transcription Factor NF-kappaB. Nucleic Acids Res 39, e67.
    Impact factor: 10.162
  44. Leung CH (Corresponding author),* Chan DSH, Man BYW, Wang CJ, Lam W, Cheng YC, Fong WF, Hsiao WLW, Ma DL.* (2011) Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3’-5’exonuclease activity. Anal Chem 83, 463.
    Front
    cover
    Impact factor:
    6.32
  45. Chan DSH, Lee HM, Yang F, Che CM, Wong CCL, Abagyan R, Leung CH (Corresponding author),* Ma DL.* (2010) Structure-Based Discovery of Natural Product-Like TNF-alpha Inhibitors. Angew Chem Int Ed 49, 2860.
    Frontispiece
    A hot paper chosen by the Editors for its importance in a rapidly evolving field of high current interest
    Highlighted by SciBX, Nature Publishing Group, 2010, 3(13)
    Impact factor: 11.994

Full Publication List

 


Professional Contributions

 

l   Ad hoc manuscript reviewers, BBA – General subjects, J Med Chem, ChemComm, Anal Chem, PLoS One, Polyhedron, Chembiochem, Nuclei Acids Res., Scientific Reports, etc.

l   Grant reviewer, Blanc – Accords bilatéraux 2013 - SIMI 7 2013 program of the French National Research Agency

l   Guest Editor, Methods Special Issues

l   Guest Editor, Current Alzheimer Research

l   Editorial Board Member, Scientific Reports, Nature Publishing Group

l   Editorial Board Member, Journal of Analytical & Molecular Techniques

l   Editorial Board Member, Austin Food Sciences           

l   Associate Member, American Association for Cancer Research

l   Panelist, The 11th Meeting of Consortium for Globalization of Chinese Medicine

l   Member, The Consortium for Globalization of Chinese Medicine

l   Member, International Society of Chinese Medicine 

 


Contact Details

Room 7037, N22
Institute of Chinese Medical Sciences (ICMS)
University of Macau
Avenida da Universidade, Taipa, Macau


Telephone: (853) 8822-4688
Fax: (853) 2884-1358
E-mail: duncanleung@umac.mo

Personal homepage: http://duncanleung.weebly.com/