Xiuping Chen

Associate Professor

 

 


Academic Qualifications

Ph.D, Peking Union Medical College (2007)     

Research Interests

Ÿ Pharmacological evaluation of natural product-induced cell death

Ÿ Natural product-based drug screening and lead compounds discovery  

 


Awards and Honors

Macao Science and Technology Awards (Second prize) (2012)

Macao Science and Technology Awards (Second prize) (2014)

17th SERVIER Young Pharmacologist Award (2013)

Outstanding Oral Presentation Award of Young Scientist in The 12th Meeting of the Asia Pacific Federation of Pharmacologists (2013)

 


List of Publications

[1]               Wenwen Zhao , Haitao Feng , Wen Sun, Kang Liu, Jin-Jian Lu, Xiuping Chen. Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion. Redox Biology. In Press.

[2]               Wenping Li, Fabrizio Papa, Jingshan Shi, Filippo Maggi, Xiuping Chen. The Chemical Constituents and the Hepato-protective Effect of the Essential Oil of Ferulago campestris (Besser) Grecescu (Apiaceae). J Essential Oil Bearing Plants. In Press.

[3]               Yanan Niu, Wen Sun, Jin-Jian Lu, Dik-Lung Ma, Chung-Hang Leung, Lixia Pei, and Xiuping Chen. PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells. Oxidative Medicine and Cellular Longevity. 2016, Article ID 4313204,

[4]               Li T, Chen X, Chen X, Ma DL, Leung CH, Lu JJ. Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells. Sci Rep. 2016 Nov 29;6:37997. doi: 10.1038/srep37997. PubMed PMID: 27897231.

[5]               Zhao W, Li C, Gao H, Wu Q, Shi J, Chen X. Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium. Front Pharmacol. 2016 Nov 8;7:418. PubMed PMID: 27891092; PubMed Central PMCID: PMC5105322.

[6]               Kang TS, Wang W, Zhong HJ, Liang JX, Ko CN, Lu JJ, Chen XP, Ma DL, Leung CH. A rhodium(III)-based inhibitor of autotaxin with antiproliferative activity. Biochim Biophys Acta. 2016 Nov 23;1861(2):256-263. doi: 10.1016/j.bbagen.2016.11.032. [Epub ahead of print] PubMed PMID: 27888146.

[7]               Wang W, Kang TS, Chan PW, Lu JJ, Chen XP, Leung CH, Ma DL. A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg(2+)-T mismatched DNA. Sci Technol Adv Mater. 2015 Nov 17;16(6):065004. PubMed PMID: 27877846.

[8]               Tang ZH, Jiang XM, Guo X, Fong CM, Chen X, Lu JJ. Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line. Oncotarget. 2016 Nov 7. doi: 10.18632/oncotarget.13150. [Epub ahead of print] PubMed PMID: 27835594.

[9]               Chen X, Wu QS, Meng FC, Tang ZH, Chen X, Lin LG, Chen P, Qiang WA, Wang YT, Zhang QW, Lu JJ. Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells. Phytomedicine. 2016 Dec 1;23(13):1555-1565. doi: 10.1016/j.phymed.2016.09.002. PubMed PMID: 27823619.

[10]           Xu XH, Li T, Fong CM, Chen X, Chen XJ, Wang YT, Huang MQ, Lu JJ. Saponins from Chinese Medicines as Anticancer Agents. Molecules. 2016 Oct 5;21(10). pii: E1326. Review. PubMed PMID: 27782048.

[11]           Gao H, Sun W, Zhao J, Wu X, Lu JJ, Chen X, Xu QM, Khan IA, Yang S. Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen). Sci Rep. 2016 Sep 26;6:33720. doi: 10.1038/srep33720. PubMed PMID: 27666387.

[12]           Zhao W, Wu C, Li S, Chen X. Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways. Cytokine. 2016 Sep 14;88:167-176. doi: 10.1016/j.cyto.2016.09.005. [Epub ahead of print] PubMed PMID: 27639126.

[13]           Xue Yang, Ziyi Wang, Yanan Niu, Xiu-Ping Chen, Simon Ming-Yuen Lee, and Ruibing Wang. “Influence of Supramolecular Encapsulation of Camptothecin by Cucurbit[7]uril: Reduced Toxicity and Preserved Anti-Cancer Activity,” MedChemComm, 2016, DOI: 10.1039/C6MD00239K,

[14]           Sun W, Wang S, Zhao W, Wu C, Guo S, Hongwei G, Hongxun T, Lu JJ, Wang Y, Chen XP. Chemical Constituents and Biological Research on Plants in the Genus Curcuma. Crit Rev Food Sci Nutr. 2016 May 26:0. [Epub ahead of print]

[15]           Zhao W, Ge H, Liu K, Chen X, Zhang J, Liu B. Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity. Planta Med. 2016 Jul 27. [Epub ahead of print] PubMed PMID: 27462872.

[16]           Tang ZH, Chen X, Wang ZY, Chai K, Wang YF, Xu XH, Wang XW, Lu JH, Wang YT, Chen XP, Lu JJ. Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Sci Rep. 2016 May 17;6:26241. doi: 10.1038/srep26241. PubMed PMID: 27184816

[17]           Xu XH, Zhang LL, Wu GS, Chen X, Li T, Chen X, Wang YT, Lu JJ. Solasodine Induces Apoptosis, Affects Autophagy, and Attenuates Metastasis in Ovarian Cancer Cells. Planta Med. 2016 Jul 27. [Epub ahead of print] PubMed PMID: 27462871.

[18]           Ren G, Luo W, Sun W, Niu Y, Ma DL, Leung CH, Wang Y, Lu JJ, Chen X. Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells. Phytomedicine. 2016 Aug 15;23(9):939-47.

[19]           Sun W, Bao J, Lin W, Gao H, Zhao W, Zhang Q, Leung CH, Ma DL, Lu J, Chen X. 2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H(2)O(2)-dependent JNK activation in cancer cells. Free Radic Biol Med. 2016 Jan 21;92:61-77.

[20]           Ran X, Zhao W, Li W, Shi J, Chen X. Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells. Korean J Physiol Pharmacol. 2016 Jul;20(4):347-55.

[21]           Zhang LL, Xu YL, Tang ZH, Xu XH, Chen X, Li T, Ding CY, Huang MQ, Chen XP, Wang YT, Yuan XF, Lu JJ. Effects of alisol B 23-acetate on ovarian cancer cells: G1 phase cell cycle arrest, apoptosis, migration and invasion inhibition. Phytomedicine. 2016 Jul 15;23(8):800-9.

[22]           Ma DL, Wang W, Mao Z, Yang C, Chen XP, Lu JJ, Han QB, Leung CH. A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms. Anal Chim Acta. 2016 Mar 24;913:41-54.

[23]           Lu L, Wang M, Mao Z, Kang TS, Chen XP, Lu JJ, Leung CH, Ma DL. A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α. Sci Rep. 2016 Mar 2;6:22458.

[24]           Liu LJ, He B, Miles JA, Wang W, Mao Z, Che WI, Lu JJ, Chen XP, Wilson AJ, Ma DL, Leung CH. Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds. Oncotarget. 2016 Mar 22;7(12):13965-75.

[25]           Wenping Li, Wenwen Zhao, Qin Wu, Yuanfu Lu, Jingshan Shi, Xiuping Chen. Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. 2016, Article ID 8541520.

[26]           Guo S, Luo W, Liu L, Pang X, Zhu H, Liu A, Lu J, Ma DL, Leung CH, Wang Y, Chen X. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target. 2016 Feb 24:1-28.

[27]           Ma G, Luo W, Lu J, Ma DL, Leung CH, Wang Y, Chen X. Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells. Chem Biol Interact. 2016 Jun 25;253:1-9.

[28]           Hao W, Zhang X, Zhao W, Zhu H, Liu ZY, Lu J, Chen X. Cryptotanshinone induces pro-death autophagy through JNK signaling mediated by reactive oxygen species generation in lung cancer cells. Anticancer Agents Med Chem. 2016;16: 593-600.

[29]           Chuanhong Wu, Jiaolin Bao, Chengwei He, Jinjian Lu, Xiuping Chen. Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells. Bangl J Pharmaco 2016;11(1)110-118. 

[30]           Zhao W, Wu C, Chen X. Cryptotanshinone Inhibits oxidized LDL-Induced Adhesion Molecule Expression via ROS Dependent NF-κB Pathways. Cell Adh Migr. 2016 May 3;10(3):248-58

[31]           Zhang X, Zhao W, Wang Y, Lu J, Chen X. The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review. Am J Chin Med. 2016;44(1):35-60.

[32]           Yang X, Wang ZY, Niu YN, Chen XP, Lee SMY, Wang RB. Influence of supramolecular encapsulation of camptothecin by cucurbit 7 uril: reduced toxicity and preserved anti-cancer activity. Medchemcomm. 2016;7:13921397.

[33]           駱瑋瑋,陸金健,陳修平,王一濤. 川楝素的藥理作用及機制研究進展. 中藥藥理與臨床.201632:(4) 161-164.

[34]           李春霞,余潔,陸遠富,吳芹,石京山,陳修平. 丹參酮類心腦血管保護作用與機制的研究進展. 中國新藥與臨床雜志. 2016;35:(8)542-546.

[35]           Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ. A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao). Planta Med. 2015 Dec;81(18):1670-87.

[36]           Wu C, Zhao W, Zhang X, Chen X. Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9.

[37]           Wu C, Chen J, Chen C, Wang W, Wen L, Gao K, Chen X, Xiong S, Zhao H, Li S. Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia. Sci Rep. 2015 Nov 5;5:16151.

[38]           Gao H, Sun W, Zhao W, Hao W, Leung CH, Lu J, Chen X. Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells. Am J Chin Med. 2015;43(6):1265-79.

[39]           Zhang X, Luo W, Zhao W, Lu J, Chen X. Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells. J Breast Cancer. 2015 Jun;18(2):112-8.

[40]           Ren G, Sha T, Guo J, Li W, Lu J, Chen X. Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells. J Nat Med. 2015 Oct;69(4):522-30.

[41]           Guo S, Chen X. The human Nox4: gene, structure, physiological function and pathological significance. J Drug Target. 2015 Dec;23(10):888-96.

[42]           Qian Ding, Jiaolin Bao, Wenwen Zhao, Yangyang Hu, Jinjian Lu, Xiuping Chen. Natural autophagy regulators in cancer therapy: a review. Phytochem Rev. 2015(14):1,137-154.

[43]           Li W, Shi J, Papa F, Maggi F, Chen X. Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d-galactosamin/lipopolysacchride-induced liver injury in rats. Nat Prod Res. 2015 May 15:1-4.

[44]           Chen SR, Chen XP, Lu JJ, Wang Y, Wang YT. Potent natural products and herbal medicines for treating liver fibrosis. Chin Med. 2015 Apr 15;10:7. doi: 10.1186/s13020-015-0036-y. eCollection 2015.

[45]           Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT,Lu JJ. Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Oncotarget. 2015 Dec 22;6(41):43911-26.

[46]           Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ. A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao). Planta Med. 2015 Dec;81(18):1670-87.

[47]           Li T, Tang ZH, Xu WS, Wu GS, Wang YF, Chang LL, Zhu H, Chen XP, Wang YT, Chen Y, Lu JJ. Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2015 Feb 15;749:81-8.

[48]           Li T, Xu XH, Tang ZH, Wang YF, Leung CH, Ma DL, Chen XP, Wang YT, Chen Y, Lu JJ. Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells. Acta Pharmacol Sin. 2015 Dec;36(12):1503-13.

[49]           Xu W, Li T, Qiu JF, Wu SS, Huang MQ, Lin LG, Zhang QW, Chen XP, Lu JJ. Anti-proliferative activities of terpenoids isolated from Alisma orientalis and their structure-activity relationships. Anticancer Agents Med Chem. 2015;15(2):228-35.

[50]           Lu L, Liu LJ, Chao WC, Zhong HJ, Wang M, Chen XP, Lu JJ, Li RN, Ma DL, Leung CH. Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity. Sci Rep. 2015 Sep 29;5:14544.

[51]           陳修平,唐正海,石哲,陸金健,蘇煥興,陳新,王一濤. 腫瘤生物學研究熱點與抗腫瘤中藥研發策略.中國中藥雜誌. 2015;40(17)3416-3422.

[52]           任國文,牛亞楠, 陸金健,王一濤,陳修平. 天然產物誘導腫瘤細胞DNA損傷應答的研究進展.中國中藥雜誌. 2015;40(24)4797-4804.

[53]           , ,石京山,陳修平. 丹參及其主要成分保肝作用的研究進展.中國中藥雜誌 2015;40(4) 588-593. 

[54]           馮海濤,陳修平,王一濤.血管平滑肌增殖模型及中藥抑制作用與機制的研究進展. 世界科學技術中醫藥現代化2015;17(5)939-944.

[55]           王雅芳, 李婷, 唐正海, 陳修平,王一濤,陸金健. 中藥黃芩的化學成分及藥理研究進展. 中華中醫藥學刊. 2015;33:(1)206-211.

[56]           李文平,石京山,陳修平. 葛根素對糖尿病及其併發症的治療作用和機制研究進展. 山東醫藥.2015;55(15)90-92.

[57]           Tang ZH, Li T, Chang LL, Zhu H, Tong YG, Chen XP, Wang YT, Lu JJ. Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. J Agric Food Chem. 2014 Dec 10;62(49):11910-6.

[58]           Chen X, Guo J, Bao J, Lu J, Wang Y. The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review. Med Res Rev. 2014 Jul;34(4):768-94.

[59]           Guo J, Wu G, Bao J, Hao W, Lu J, Chen X. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PLoS One. 2014 Feb 4;9(2):e88140.

[60]           Guo J, Zhao W, Hao W, Ren G, Lu J, Chen X. Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells. Anticancer Agents Med Chem. 2014;14(8):1146-53.

[61]           Wenhui Hao, Xuenong Zhang, Wenwen Zhao, Xiuping Chen. Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells. PeerJ. 2014 Sep 9;2:e555.

[62]           Zhao W, Ma G, Chen X. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-κB pathway. Vascul Pharmacol. 2014 Dec;63(3):162-72.

[63]           Tang ZH, Li T, Gao HW, Sun W, Chen XP, Wang YT, Lu JJ. Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells. Chin Med. 2014 Jun 9;9:16.

[64]           Zhong Z, Tan W, Chen X, Wang Y. Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro. Eur J Pharmacol. 2014 Aug 15;737:1-10.

[65]           Li T, Xu WS, Wu GS, Chen XP, Wang YT, Lu JJ. Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells. Asian Pac J Cancer Prev. 2014;15(4):1745-9.

[66]           Zhu H, Liao SD, Shi JJ, Chang LL, Tong YG, Cao J, Fu YY, Chen XP, Ying MD, Yang B, He QJ, Lu JJ. DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal. Free Radic Biol Med. 2014:S0891-5849 (14)00143-9.

[67]           Xu WS, Li T, Wu GS, Dang YY, Hao WH, Chen XP, Lu JJ, Wang YT. Furanodiene activates the molecules regulating G1 cell cycle arrest, apoptosis and autophagy, and slightly inhibits key steps of cell metastasis in 95-D lung cancer cells. Am J Chin Med. 2014;42(1):243-55.

[68]           Xu WS, Dang YY, Chen XP, Lu JJ, Wang YT. Furanodiene Presents Synergistic Anti-proliferative activity with paclitaxel via altering cell cycle and integrin signaling in 95-D lung cancer cells. Phytotherapy Research. 2014 Feb;28(2):296-9.

[69]           馬桂鑫,趙文文,陳修平. 血管內皮細胞損傷保護模型及中草藥保護作用研究進展.中草藥, 2014;45(2)276-283.

[70]           丁倩,張學農,陳修平. 調節自噬,白藜蘆醇生物學活性的新機制.中國新藥與臨床雜誌,中國新藥與臨床雜誌 2014(33)9:634-638.

[71]           郝文慧,趙文文,陳修平. 丹參酮類抗腫瘤作用與機制研究進展. 中國藥理學通報 2014; 30(8): 1041-1044.

[72]           Chen X, Lu J, Bao J, Guo J, Shi J, Wang Y. Adiponectin: a biomarker for rheumatoid arthritis? Cytokine Growth Factor Rev. 2013 Feb;24(1):83-9.

[73]           Chen X, Pei L, Lu J. Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction? Complement Ther Med. 2013 Jun;21(3):272-5.

[74]           Chen X. Target network analysis of adiponectin, a multifaceted adipokine. J Cell Biochem. 2013 May;114(5):1145-52.

[75]           Kong Q, Sun F, Chen X. Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation. Cell J. 2013 Summer;15(2):160-5.

[76]           Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT. Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. PLoS ONE. 2013 Oct 29;8(10): e76620.

[77]           Wu GS, Guo JJ, Bao JL, Li XW, Chen XP, Lu JJ, Wang YT. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum - a review. Expert Opin Investig Drugs. 2013;22(8):981-992.

[78]           Wu GS, Lu JJ, Guo JJ, Huang MQ, Gan L, Chen XP, Wang YT. Synergistic anti-cancer activity by the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Pharmacological Reports. 2013; 65 (2): 453-9.

[79]           Huang MQ, Xu W, Wu SS, Lu JJ, Chen XP. A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats. Food Chem Toxicol. 2013;58: 318-23. 

[80]           Dai D, Pei L, Tang L, Chen F, Chen X. LC-MS/MS determination of bakkenolide D in rats plasma and its application in pharmacokinetic studies. Biomed Chromatogr.2013 Sep;27(9):1200-7.

[81]           Pei L, Bao Y, Liu S, Zheng J, Chen X. Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology. PLoS One. 2013;8(2):e57414.

[82]           Xu Z, Wu G, Wei X, Chen X, Wang Y, Chen L. Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells. Am J Chin Med. 2013;41(3):615-28.

[83]           Zhi-Qiao Ma, Jin-Jian Lu, Wen-Shan Xu, Xiu-Ping Chen, Hao Hu, Yi-Tao Wang. Analysis of traditional chinese medicine injections used in the treatment of respiratory system-related diseases based on the Chinese market. Global J Res. Med. Plants & Indigen. Med. 2013; 2(7):499–508.

[84]           李婷, 徐文珊, 李西文, 陳修平, 陸金健. 中藥桔梗的現代藥理研究進展. 中藥藥理與臨床, 2013;29(2)205-208.

[85]           畢超,王言才,陳修平,鄭穎. 薑黃素納米混懸液的抗癌活性及細胞攝取研究. 中藥新藥與臨床藥理. 2013;24(4):416-420.

[86]           賴雲鋒, 陸金健, 陳修平, 胡豪, 王一濤. 基於市場狀況的抗腫瘤中藥注射劑分析. 世界科學技術中醫藥現代化. 2013;14(5):1958-1962.

[87]           冉小麗,吳芹,石京山,陳修平. 凝集素樣氧化型低密度脂蛋白受體1在動脈粥樣硬化中的作用. 中國藥理學與毒理學雜誌 2013;27(5)865-871.

[88]           Chen X, Bao J, Guo J, Ding Q, Lu J, Huang M, Wang Y. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer. Anticancer Drugs. 2012 Sep;23(8):777-87.

[89]           Huang M, Lu JJ, Huang MQ, Bao JL, Chen XP, Wang YT. Terpenoids: natural products for cancer therapy. Expert Opin Investig Drugs. 2012 Dec;21(12):1801-18.

[90]           Huang M, Xie Y, Chen L, Chu K, Wu S, Lu J, Chen X, Wang Y, Lai X. Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats. Phytother Res. 2012 Jun;26(6):944-8.

[91]           Lu JJ, Bao JL, Chen XP, Huang M, Wang YT. Alkaloids isolated from natural herbs as the anti-cancer agents. Evid-Based Compl Alt. 2012.

[92]           Lu JJ, Bao JL, Wu GS, Xu WS, Huang MQ, Chen XP, Wang YT. Quinones derived from plant secondary metabolites as anti-cancer agents. Anti-Cancer Agent Me. 2012,13(3):456-63.

[93]           Lu JJ, Dang YY, Huang M, Xu WS, Chen XP, Wang YT. Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review. J Ethnopharmacol. 2012 143(2):406-11.

[94]           Xu WS, Dang YY, Guo JJ, Wu GS, Lu JJ, Chen XP, Wang YT. Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells. Evid Based Complement Alternat Med. 2012;2012:426521.

[95]           Pei L, Bao Y, Ma L, Wang Q, Ye Y, Han X, Liu S, Chen X. A Sensitive Method for Determination of Platycodin D in Rat Plasma Using Liquid Chromatography/Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study. Planta Med. 2011;78(3): 244-51.

[96]           Pei L, Dai D, Bao Y, Chen F, Zheng J, Li J, Liu S, Chen X. Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Mass Spectrom. 2012 Aug;47(8):962-8.

[97]           Pei L, Liu S, Zheng J, Chen X. A sensitive method for determination of furanodiene in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. Biomed Chromatogr. 2012 Jul;26(7):826-32.

[98]           Zhong ZF, Li YB, Wang SP, Tan W, Chen XP, Chen MW, Wang YT. Furanodiene enhances  amoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPARγ independent manner. J Cell Biochem. 2012;113(8):2643-51.

[99]           Zhong Z, Dang Y, Yuan X, Guo W, Li Y, Tan W, Cui J, Lu J, Zhang Q, Chen X, Wang Y. Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. Cell Physiol Biochem. 2012;30(3):778-90.

[100]       Zhong ZF, Hoi PM, Wu GS, Xu ZT, Tan W, Chen XP, Cui L, Wu T, Wang YT. Anti-angiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo. J Ethnopharmacol. 2012 Jun 1;141(2):721-7.

[101]       Wu G, Qian Z, Guo J, Hu D, Bao J, Xie J, Xu W, Lu J, Chen X, Wang Y. Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells. Am J Chin Med. 2012;40(3):631-42.

[102]       Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia.2012;83(2):408-14.

[103]       Xu Z, Chen X, Fu S, Bao J, Dang Y, Huang M, Chen L, Wang Y. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85.

[104]       Lai Yunfeng, Lu Jinjian, Chen Xiuping, Hu Hao, Wang Yitao. Analysis of Anti-cancer Traditional Chinese Medicine Injections based on Market Performance. Mode Tradit Chin Med Mater Med. 2012; 14(5): 1958–1962.

[105]       HUANG Ming-qing, XIE You-liang, LAI Xiao-ping, LIN Ling, XU Yin-ji, LU Jin-jian, CHEN Xiu-ping. Protection of Total Flavonoid Fraction from Nervilia fordiion Lipopolysaccharide-induced Acute Lung Injury in Rats. Chinese Herbal Medicines, 2012; 4(4):287-293

[106]       Xiuping Chen, Jiajie Guo, Jiaolin Bao, Wenshan Xu, Yanjuan Huang, Yitao Wang. Screening europrotective Agents Through 4-hydroxynonenal, Ethanol, High Glucose, Homocysteine, Okadaic Acid, Rotenone, and Oxygen-Glucose Deprivation Induced PC12 Injury Models: A Review. Current Psychopharmacology. 2012:1(1)103-110.

[107]       黃鳴清, 許文, 褚克丹, 陸金健, 陳修平, 一濤. 基於GLUT4轉位的中藥及活性成分改善胰島素抵抗研究進展.中國實驗方劑學雜誌,2012;18(16)343-346.

[108]       陳修平,陸金健,郭佳傑,鮑嬌琳,徐文珊,丁倩,王一濤. 基於天然產物的藥物研發對創新中藥研究的啟示. 藥學學報, 2012;47(11)1-6

[109]       陳修平,石京山. HPLC-螢光法測定醛糖還原酶的活性. 中國藥理學通報 2012;28(10): 1472-1475.

[110]       陸金健, 黃鳴清, 陳修平, 王一濤. 二氫青蒿素抗腫瘤作用及其機制研究進展. 中國藥理學與毒理學雜誌 2012,26(3)397-401.

[111]       徐文珊,黃鳴清,陳修平, 王一濤. 天然產物來源的芳香化酶抑制劑研究進展. 時珍國醫國藥 2012,(4)1008-1011.

[112]       鮑嬌琳,陸金健,陳修平,王一濤. 苦參堿與氧化苦參堿抗腫瘤作用及其機制的研究進展. 中藥新藥與臨床藥理 2012,23(3)367-372.

[113]       陸金健,黃鳴清,陳修平,王一濤. 表達蛋白質組學在抗腫瘤藥物研發中的應用.中國新藥雜誌 2012,21(1)43-47.  

[114]       Chen X, Pei L, Zhong Z, Guo J, Zhang Q, Wang Y. Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine. 2011 Nov 15;18(14):1238-43.

[115]       Chen X, Zhong Z, Xu Z, Chen L, Wang Y. No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells. Pharmacol Rep. 2011;63(3):724-32.

[116]       Chen X, Xu Z, Wang Y. Recent advances in breast cancer metastasis suppressor 1. Int J Biol Markers. 2011; 26(1):1-8. 

[117]       Chen X, Sun F, Ma L, Wang J, Qin H, Du G. In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit. Indian J Pharmacol. 2011 May;43(3):320-3.

[118]       Sun Y, Chen X. Ox-LDL-induced LOX-1 expression in vascular smooth muscle cells: role of reactive oxygen species. Fundam Clin Pharmacol. 2011;25(5):572-9.

[119]       Chen X, Wang Y. Adiponectin and breast cancer. Med Oncol. 2011;28(4):1288-95.

[120]       Zhong Z, Chen X, Tan W, Xu Z, Zhou K, Wu T, Cui L, Wang Y. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. Eur J Pharmacol. 2011; 667(1-3):50-5.

[121]       Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. Am J Chin Med. 2011;39(1):15-27.

[122]       Xu Z, Chen X, Zhang Q, Chen L, Wang Y. Corydalis yanhusuo W.T. Wang extract inhibits MCF-7 cell proliferation by inducing cell cycle G2/M arrest. Am J Chin Med. 2011;39(3):579-86.

[123]       Wu HL, Wang Y, Zhang P, Li SF, Chen X, Chen YK, Li JG, Yang SM, Su YP, Wang JP, Chen B. Reversible immortalization of rat pancreatic β cells with a novel immortalizing and tamoxifen-mediated self-recombination tricistronic vector. J Biotechnol. 2011;151(3): 231 -41.

[124]       Tan W, Lu J, Huang M, Li Y, Chen M, Wu G, Gong J, Zhong Z, Xu Z, Dang Y, Guo J, Chen X, Wang Y. Anti-cancer natural products isolated from chinese medicinal herbs. Chin Med. 2011 Jul 22;6(1):27.

[125]       陳修平, 裴麗霞, 王一濤. 創新中藥研究與開發模式之探討. 中草藥 2011, 42(7)1255-1260.

[126]       陳修平,胡元佳,王一濤. 中藥方劑創新研究的啟示與思考. 世界科學技術-中醫藥現代化 2011,13 (4)704-706.

[127]       陳修平,鐘章鋒,徐曾濤,燕茹,李澎濤,王一濤. 淺論基於藥效物質基礎的中藥(複方)藥動學. 世界科學技術-中醫藥現代化 2011,13(1):137-142.

[128]       傅舒,陸金健,陳修平,王一濤. 莪術中萜類成分抗腫瘤作用的研究進展. 華西藥學雜誌2011 26(6)604-606.

[129]       Chen X, Zhong Z, Xu Z, Chen L, Wang Y. 2',7'-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy. Free Radic Res. 2010; 44(6):587-604.

[130]       Yiyi Sun, Xiuping Chen. Effect of adiponectin on apoptosis: pro-apoptosis or anti-apoptosis ? Biofactors. 2010;36(3):179-86.   

[131]       Chen X, Zhang H, McAfee S, Zhang C. The reciprocal relationship between adiponectin and LOX-1 in the regulation of endothelial dysfunction in ApoE knockout mice. Am J Physiol Heart Circ Physiol. 2010; 299(3):H605-12.

[132]       陳修平, 尋克麗, 王一濤. 中藥復方藥效物質基礎的系統藥理學評價.中草藥2010;41(1)1-5.

[133]       鐘章鋒,陳修平,吳鐵,王一濤. 莪術醇的研究進展. 中國藥房 2010;12(31)2959-2961.

[134]       陳修平,趙海譽,鐘章鋒,徐增濤,王一濤. “Ox-LDL-LOX-1-ROS” signaling pathway involvement in foam cell formation.中國動脈硬化雜誌 2010;18(7):577-581. 

[135]       Sun Y, Xun K, Wang C, Zhao H, Bi H, Chen X, Wang Y. Adiponectin, an unlocking adipocytokine. Cardiovasc Ther. 2009 ;27(1):59-75.

[136]       Sun Y, Xun K, Wang Y, Chen X. A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anticancer Drugs. 2009; 20(9):757-69.  

[137]       Chen X, Xun K, Chen L, Wang Y. TNF-alpha, a potent lipid metabolism regulator. Cell Biochem Funct. 2009 Oct;27(7):407-16.

[138]       Zhang H, Park Y, Wu J, Chen X, Lee S, Yang J, Dellsperger KC, Zhang C. Role of TNF-alpha in vascular dysfunction. Clin Sci (Lond).2009;116 (3):219-30.

[139]       黨元野,陳修平,張慶文,王一濤. 辣椒堿的藥理作用研究進展. 中藥藥理與臨床2009;25(4)84-89.

[140]       Chen X, Zhang T, Du G. Advanced glycation end products serves as ligand for lectin-like oxidized low density lipoprotein receptor-1 (LOX-1): biochemical and binding characterizations assay. Cell Biochem Funct. 2008;17:1-11.

[141]       Sun FY, Chen XP, Wang JH, Qin HL, Yang SR, Du GH. Arjunic Acid, a Strong Free Radical Scavenger from Terminalia arjuna. Am J Chin Med. 2008;36(1):197-207.  

[142]       Chen XP, Du GH. High-throughput screening for reactive oxygen species scavengers targeting mitochondria. Methods Find Exp Clin Pharmacol. 2008 May;30(4):255-60.

[143]       XP Chen, Bradley T. AM Hill, CH Zhang. Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction. Current Hypertension Review. 2008;4(4): 245-255. 

[144]       Chen XP, Xun KL, Wu Q, Zhang TT, Shi JS, Du GH. Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species. Vascular pharmacology. 2007,47(1),1-9.

[145]       Chen XP, DU GH. Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance. Chin Med J (Engl). 2007 Mar 5;120(5):421-6.

[146]       Chen XP, Zhang TT, Du GH. Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis? Cardiovasc Drug Rev. 2007;25 (2):146- 61.

[147]       XP Chen, GH Du. Target validation: A door to drug discovery. Drug Discov Ther 2007;1(1):23-29.

[148]       陳修平,杜冠華. 二氯螢光素雙醋酸鹽40年的應用與爭論. 醫藥導報 2007;26(4)343-349.

[149]       陳修平,王鈺瑩,王淼,吳芹,石京山,杜冠華. RP-HPLC熒光法測定兔血漿中秦皮甲素的濃度.中國藥理學通報2007;23(4):522-524.

[150]       Zhang TT, Huang ZT, Dai Y, Chen XP, Zhu P, Du GH. High-throughput fluorescence polarization method for identifying ligands of LOX-1. Acta Pharmacol Sin 2006;27(4): 447-52.

[151]       Zhang T, Huang Z, Dai Y, Chen X, Zhu P, Du G.. The expression of recombinant human LOX-1 and identifying its mimic ligands by fluorescence polarization-based high throughput screening. J Biotechnol. 2006;125(4): 492-502.

[152]       孫芳雲,張斌,劉慶山,何國榮,陳修平,秦海林,杜冠華. 西藏地產藏藥大葉秦艽的抗潰瘍病作用研究. 時珍國醫國藥2006;17(3)312-313.

[153]       陳修平,龔啟海,袁牧,謝笑龍,陸遠富,吳芹,黃彬,楊丹莉,石京山. RP-HPLC法測定大鼠血漿中萘呱地爾羥基代謝物濃度及藥代動力學.藥物分析雜誌2006;26(5)609-613.

[154]       陳修平,杜冠華. 環氧化酶COX-2, 動脈粥樣硬化治療的新靶點?醫藥導報2005;24(12) 1089-1091.

[155]       陳修平,吳芹,尋克麗,石京山.萘呱地爾衍生物BWJ對麻醉大鼠及貓血壓的影響.遵義醫學院學報 2004;27(5)424-428.

[156]       Shi JS, Yu JX, Chen XP, Xu RX. Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline. Acta Pharmacol Sin. 2003;24(2):97-101.

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University of Macau, Avenida da Universidade, Taipa, Macau, China
E-mail: xpchen@umac.mo