State Key Laboratory of Quality Research in Chinese Medicine

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  • Using carrier drug delivery system to improve active fat-soluble components of Chinese herbal medicine dissolution, stability and oral absorption;

    Epimedium flavone: this study using the solvent precipitation preparation of epimedium glycoside yuan Icaritin (ICT) nanoparticle suspension liquid in order to improve its dissolution and oral bioavailability. Dissolution experiment, body evaluation, the results suggest that serum pharmacology nanoparticle suspension liquid is better than technical coarse mixed suspension. Nanoparticle suspension liquid is a kind of ICT has the potential to be developed into anti osteoporosis oral nanoparticles preparation.

    Curcumin: curcumin solid lipid nanoparticle was prepared, and antitumor activity in vitro and in vivo pharmacokinetic aspects of evaluation. The results show that the improved significantly compared with the technical preparation of curcumin in phosphate buffer solution and the stability of cell culture. Cells in vitro experiments showed that the preparation embodies the continuous inhibition of tumour cells for a longer time. Preparation of curcumin can be tumor cells to absorb, intake increased with the extension of incubation time. Pharmacokinetic experiments show that the clearance rate slower than technical preparations in the body.

    Radix scutellariae element: the use of spray freeze drying technology for the preparation of radix scutellariae, solid dispersions disease in vivo pharmacokinetic evaluation. With a low glass transition temperature and low melting point of materials (Pluronic F68) as the carrier, using spray freeze drying of the solid dispersions of radix scutellariae element, and will be made by the samples with the conventional solvent evaporation - compared to the sample prepared. Spray freeze drying technology can effectively improve the oral bioavailability of radix scutellariae element. This part of the spray freeze drying part of the findings are published in SCI journals in English AAPS PharmSciTech.

    Salvia miltiorrhiza extract: selecting water-soluble ingredients =, rosemary acid and phenolic acid B, Dan fat-soluble ingredients hidden tanshinone and tanshinone Ⅱ five component A as index ingredient, respectively by polyvinylpyrrolidone (PVP10) and ray parlour gresham (F127) and the two combinations (PVP10 - F127) as the carrier, the spray drying of salvia miltiorrhiza extract prepared by solid dispersion, and its physical properties. The results showed that salvia miltiorrhiza extract of multicomponent respectively achieved synchronization released in full, accord with the requirement of "Chinese pharmacopoeia" dissolution in vitro. This part of the findings are published in core journals in Chinese journal of Chinese herbal medicine.

  • Active ingredients of Chinese herbal medicine absorption in vitro metabolism study, to do preliminary basis for dosage form design

    Epimedium flavonoids that epimedium flavone glycosides of oral absorption is very poor, and it is caused due to their poor membrane permeability. Icariside II will quickly after intravenous drug distribution to all organizations, including the kidneys, lungs and liver. Other organizations such as muscle, heart, spleen, there are also some distribution in blood. In testicular drug concentration is very low, can't detect drugs in the brain tissue. This part of the findings are published in SCI journals in English Chromatographia. Lamps, : this section optimization using in vitro Caco - 2 lamps, and the people deeply microsome were studied and the intestinal absorption of metabolic mechanism and the first. Experimental results show that the lamps b element and its glycosides, yuan yi optimization in the form of passive diffusion through Caco - 2 monolayer cell membranes, and lamps ethyl glucoside yuan has high apparent permeability coefficient, absorbed by speculation after think is the main form. And lamp b element glycosides yuan mainly by humans in the human liver and small intestine glucose acid transferase 1 a1, 1 a3, 1 a9 of glucuronic acid combined with metabolism. This part of the findings are published in English on SCI journals Xenobiotica.