State Key Laboratory of Quality Research in Chinese Medicine

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Phytochemistry

  • This year's chemical research mainly around the lingnan Chinese chemistry and quality research as well as commonly used traditional Chinese medicine coptis chinensis and ganoderma lucidum chemical research work, at the same time, the separation of low boiling point volatile components has carried on the preliminary study. This year completed save bing, mulberry, guangdong three fork, five fingers wild peach, Chinese eupatorium root, bergamot, wood butterfly, guava leaf, this leaves, turmeric 10 kinds of traditional Chinese medicine (TCM) chemical composition analysis and research work.

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  • Research on the chemical composition of rhizoma coptidis

    Use a variety of chromatographic techniques from the 90% ethanol extracts of rhizoma coptidis rhizome 36 monomer compounds were isolated, identified 34 compounds structure: alkaloids: 5 - hydroxy - 8 - oxidation method alkaline (1), rhizoma coptidis alkaline (2), table berberis alkaline (3), Martin (4), 8 - coptis alkaline oxide (5), canadine (6), berberis alkaline oxide (7), purple pansy (8), berbithine (9), 6 - ([1, 3] dioxolo [4, 5 - g] isoquinoline - 5 - carbonyl) 2, 3 - dimethoxy - benzoic acid methyl ester (10), berberis alkaline (11); Lignans: clove fat element (12), table clove fat element (13), threo - guaiacylglycerol - to decide - O - 4 '- coniferyl Mr (14), erythro - guaiacylglycerol - 8 - O - 4' - (coniferyl alcohol) Mr (15), (+) - 5 '- methoxy resin element (16), (+) - 5' - methoxy larch resin alcohol (17), (+) - larch resin alcohol (18), alcohol (19) (+) - larch resin, rosin element (20); Flavonoids: drug element (21), chrysin (22), 3 - hydroxy - 1 - (2 - hydroxy - 5 - methoxyphenyl) - 2 - (4 - hydroxy - 3 - methoxyphenyl) - 1 - propanone (23), rat Li Su (24). Other: ferulic acid (25), vanillic acid (26), 3 - indole formaldehyde (27), 3, 4-2 hydroxy benzene ethanol (28), 5 - HMF (29), Z - coffee stearic acid glycol ester (30), limonin (31), chlorogenic acid (32), carrot glycosides (33), beta sitosterol (34). Among them compound 1 as the new compounds, compounds 9,12,13,14,15,16,17,21,22,23,24,26,27,29,30 all compounds were isolated from this plant for the first time

  • The chemical composition of ganoderma lucidum

    Ethyl acetate extract of red ganoderma lucidum ethanol extracts of areas to study the chemical composition. From 23 compounds were isolated by chemical methods and the modern spectrum technology of 15 compounds were identified the structure of benzoic acid (GL), respectively, 2, 5 - dihydroxy acetophenone (GL - 2), rhubarb phenol (GL - 3), emodin (GL - 4), 24 alkanes (GL - 5), 24 alkanes are acid (GL - 6), ursolic acid (GL - 7), three alcohol ketone of ganoderma lucidum (GL - 8), ganoderma lucidum alcohol (GL - 9), ganoderma lucidum acid S (GL - 10), ergosterol (GL - 11), ergot steroid - 7, 22 - diene - 3 beta - alcohol (GL - 12), ergot steroid - 7, 22 - diene - 3 beta - O - palmitate (GL - 13), beer sterol (GL - 14), beta sitosterol (GL - 15). GL - among them, compounds 3 ~ GL - 4 for the first time, were obtained from ganoderma, compound GL - 2 isolated from red ganoderma lucidum fruiting body for the first time.

  • The quality of the lingnan Chinese drugs researchs

    Established save bing, guangdong mulberry, three fork, five fingers wild peach, Chinese eupatorium root, bergamot, wood butterfly, pomegranate leaves, this leaves, turmeric 10 kinds of Chinese medicine major chemical HPLC detection analysis.

  • The study the composition of volatile

    Using silica gel column chromatography combined with high-speed countercurrent chromatography for goods of volatile component is studied, was isolated from the 6 low boiling point components, structure analysis is underway.