陳肖家

助理教授

 

學歷

• 澳門大學碩士、博士

• 北京大學學士、碩士

 

主講科目

待定

 

學術研究

研究方向

• 中藥活性成分的提取分離與鑒定

• 中藥質量評價的關鍵技術

• 中藥國際質量標準

 

本課題組竭誠歡迎對藥物分析和中藥質量評價有興趣的博、碩士研究生的加盟!詳情請諮詢陳肖家博士:xiaojiachen@umac.mo

 

科研論著

 

期刊論文

  1. Zhang, Q.R., Yu, H., Qi, J., Tang, D.S., Chen, X.J., Wan, J.B., Li, P., Hu, H., Wang, Y.T., Hu, Y.J. Natural formulas and the nature of formulas: Exploring potential therapeutic targets based on traditional Chinese herbal formulas. Plos One. 2017, 12(2): e0171628.
  2. Xu, X.H., Li, T., Fong, C.M.V., Chen, X.P., Chen, X.J., Wang, Y.T., Huang, M.Q., Lu, J.J. Saponins from Chinese Medicines as Anticancer Agents. Molecules. 2016, 21(10): 1326.
  3. Chen, X.J., Zhang, X.J., Shui, Y.M., Wan, J.B., Gao, J.L. Anticancer activities of protopanaxadiol- and protopanaxatriol type ginsenosides and their metabolites. Evidence-Based Complementary and Alternative Medicine. 2016, 5738694.
  4. Chen, M.H., Chen, X.J. (Co-first author), Wang, M., Lin, L.G., Wang, Y.T. Ophiopogon japonicus—A phytochemical, ethnomedicinal and pharmacological review. Journal of Ethnopharmacology. 2016, 181 : 193-213.
  5. Chen, X.J., Qiu, J.F., Wang, Y.T., Wan, J.B. Discrimination of three Panax species based on difference in volatile organic compounds using static headspace GC-MS-based metabolomics approach. American Journal of Chinese Medicine. 2016, 44(3) : 663-676.
  6. Zhang, L.L., Tian, K., Tang, Z.H., Chen, X.J., Bian, Z.X., Wang, Y.T., Lu, J.J. Phytochemistry and pharmacology of Carthamus tinctorius L. American Journal of Chinese Medicine. 2016, 44(2) : 197-226.
  7. Tang, Z.H., Li, T., Tong, Y.G., Chen, X.J., Chen, X.P., Wang, Y.T., Lu, J.J. A systematic review of the anticancer properties of compounds isolated from Licorice (Gancao). Planta Medica. 2015, 81(18): 1670-1687.
  8. Chen, X.J., Tang, Z.H., Li, X.W., Xie, C.X., Lu, J.J., Wang, Y.T. Chemical constituents, quality control, and bioactivity of Epimedii Folium (Yinyanghuo). American Journal of Chinese Medicine. 2015, 43(5): 783-834.
  9. Cai, Y., Li, X.W., Li, M., Chen, X.J., Hu, H., Ni, J.Y., Wang, Y.T. Traceability and quality control in traditional Chinese medicine: From chemical fingerprint to two-dimensions. Evidence-Based Complementary and Alternative Medicine. 2015, 251304.
  10. Yang, Z.M., Zhao, J., Lao, K.M., Chen, X.J., Leong, F., Wang, C.Z., Yuan, C.S., Li, S.P. Determination of six polyynes in Oplopanax horridus and Oplopanax elatus using polyethylene glycol modified reversed migration microemulsion electrokinetic chromatography. Electrophoresis. 2014, 35(20), 2959-2964.
  11. Li, G.L, Han, W.L., Jiang, W., Zhang, D.M., Ye, W.C., Chen, X.J., Ma, A.D. Quantitative determination of arenobufagin in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2013, 939, 86-91.
  12. Xu, J., Han, Q.B., Li, S.L., Chen, X.J., Wang, X.N., Zhao, Z.Z., Chen, H.B. Chemistry, bioactivity and quality control of Dendrobium, a commonly used tonic herb in traditional Chinese medicine. Phytochemistry Reviews, 2013, 12, 341-367.
  13. Lao, K.M., Han, D.Q., Chen, X.J., Zhao, J., Wang, T.J., Li, S.P. Simultaneous determination of seven hydrophilic bioactive compounds in water extract of Polygonum multiflorum using pressurized liquid extraction and short-end injection micellar electrokinetic chromatography. Chemistry Central Journal, 2013, 7, 45.
  14. Han, D.Q., Zhao, J., Xu, J., Peng, H.S., Chen, X.J., Li, S.P. Quality evaluation of Polygonum multiflorum in China based on HPLC analysis of hydrophilic bioactive compounds and chemometrics. Journal of Pharmaceutical and Biomedical Analysis, 2013, 72, 223-230.
  15. Chen, X.J., Dinh, N.P., Zhao, J., Wang, Y.T., Li, S.P., Svec, F. Effect of ion adsorption on CEC separation of small molecules using hypercrosslinked porous polymer monolithic capillary columns. Journal of Separation Science, 2012, 35(12), 1502-1505.
  16. Chen, X.J., Zhao, J., Wang, Y.T., Huang, L.Q., Li, S.P. CE and CEC analysis of phytochemicals in herbal medicines. Electrophoresis, 2012, 33(1), 168-179.
  17. Xu, J., Guan, J., Chen, X.J., Zhao, J., Li, S.P. Comparison of polysaccharides from different Dendrobium using saccharide mapping. Journal of Pharmaceutical and Biomedical Analysis, 2011, 55(5), 977-983.
  18. Chen, X.J., Yang, F.Q., Wang, Y.T., Li, S.P. CE and CEC of nucleosides and nucleotides in food materials. Electrophoresis, 2010, 31(13), 2092-2105.
  19. Chen, X.J., Zhao, J., Meng, Q., Li, S.P., Wang, Y.T. Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection. Journal of Chromatography A, 2009, 1216(43), 7329-7335.
  20. Jiang, Y., Li, S.P.,Wang, Y.T., Chen, X.J., Tu, P.F. Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry. Journal of Chromatography A, 2009, 1216(11), 2156-2162.
  21. Chen, X.J., Tu, P.F., Jiang, Y., Wang, Y.T., Li, S.P. Effect of stability of internal standard on quantification of 15 flavonoids in Epimedium using CZE. Journal of Separation Science, 2009, 32(2), 275-281.
  22. Chen, X.J., Ji, H., Wang, Y.T., Li, S.P. Simultaneous determination of seven flavonoids in Epimedium using pressurized liquid extraction and capillary electrochromatography. Journal of Separation Science, 2008, 31(5), 881-887.
  23. Chen, X.J., Ji, H., Zhang, Q.W., Tu, P.F., Wang, Y.T., Guo, B.L., Li, S.P. A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 2008, 46(2), 226-235.
  24. Chen, X.J., Guo, B.L., Li, S.P., Zhang, Q.W., Tu, P.F., Wang, Y.T. Simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography. Journal of Chromatography A, 2007, 1163(1-2), 96-104.
  25. Jiang, Y., Tu, P.F., Chen, X.J., Zhang, T.Y. Isolation of two sucrose esters from Polygala tenuifolia by high speed countercurrent chromatography. Journal of Liquid Chromatography & Related Technologies, 2005, 28(10), 1583-1592.
  26. 張元杰, 錢正明, 陳肖家, 楊豐慶, 李紹平. HPLC法同時測定補益中藥中尿苷、腺嘌呤、鳥苷和腺苷的含量. 藥物分析雜誌, 2010. 30(1), 33-36.
  27. 陳肖家, 李紹平, 王一濤, 屠鵬飛. HPLC、UPLC、CZE測定淫羊藿中黃酮類成分含量的比較研究. 中國藥學雜誌, 2008, 43 (8), 624-628.
  28. 陳肖家, 張慶文, 季暉, 王一濤, 屠鵬飛, 李紹平. 紫外分光光度法和高效液相色譜法測定淫羊藿總黃酮含量的比較研究. 藥物分析雜誌, 2007, 27(5), 625-630.

 

 

 

專著

  1. Li, S.P., Chen, X.J., Yang, F.Q. Application of chemometrics in capillary electrophoresis analysis of herbal medicines. In: Hanrahan, G., Gomez, F.A. (Eds.), Chemometric methods in capillary electrophoresis (pp. 227-242). Hoboken, New Jersey. John Wiley & Sons, Inc., 2010.
  2. 陳肖家等. (副主編). In: 李紹平, 王一濤主編, 常用中藥色譜分析方法. 澳門大學出版中心. (ISBN: 978-99937-970-6-7), 2009.
  3. Chen, X.J., Wang, Y.T., Li, S.P. Yinyanghuo (Epimedium spp.) In: Li, S.P., Wang, Y.T. (Eds.), Pharmacological Activity-Based Quality Control of Chinese Herbs. (pp. 217-234) New York. Nova Publishers, Inc., 2008.
  4. Guan, J., Chen, X.J., Li, SP. Recent development on analytical techniques for quality control of Chinese herbs. In: Li, S.P., Wang, Y.T. (Eds.), Pharmacological Activity-Based Quality Control of Chinese Herbs. (pp. 73-113) New York. Nova Publishers, Inc., 2008.

 

 

學術獎勵

  1. 陳肖家. 澳門科學技術發展基金, 澳門特別行政區研究生科技研發獎. 2012
  2. Chen, X.J., Dinh, N.P., Zhao, J., Li, S.P., Wang, Y.T., Irgum, K., Svec, F. Effect of ion adsorption on capillary electrochromatographic separation of small molecules using hypercrosslinked monolithic capillary columns. CASSS Student Travel Grants. The 38th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (HPLC 2012), 2012.
  3. 李紹平, 王一濤, 楊豐慶, 李鵬, 萬建波, 陳肖家.加壓溶劑提取在中藥質量控制中的應用. 中國藥學會科學技術三等獎, 2008.
  4. 陳肖家, 李紹平, 王一濤. HPLC、UPLC和CZE測定淫羊藿中黃酮類成分的比較研究. 中國藥學會中國藥學雜誌島津杯第八屆全國藥物分析優秀論文評選交流會優秀論文二等獎, 2007.

 

 

 

專業認證

 

 

聯絡方法

澳門大學中華醫藥研究院
中國澳門氹仔大學大馬路


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電郵:xiaojiachen@umac.mo