Richard Dequan YE

Chair Professor

Academic Qualifications | Teaching | Research | Publications | Service |Contact Details


Academic Qualifications

  • Ph.D., Washington University in St. Louis

Teaching

(TBD)


Research

Research Interests

Research interests:

  • Immunopharmacology with an emphasis on the regulation of inflammation.
  • G protein-coupled receptors and signal transduction
  • Drug screening based on receptors and signal transduction

After completion of medical education in China, Dr. Ye went to the U.S. to study cell biology, hematology, immunology and pharmacology in the Ph.D. program at Washington University in St. Louis. After a postdoctoral training in cell biology, Dr. Ye worked at The Scripps Research Institute as assistant professor and associate professor, and then at the University of Illinois at Chicago as associate professor and full professor. He returned to China in 2010, becoming a Zhiyuan Chair Professor at Shanghai Jiao Tong University and Dean of the School of Pharmacy. Dr. Ye is a “1000 Talent Program” Scholar. He is presently a Chair Professor at the University of Macau, with research interests in immunopharmacology, including activation mechanisms for G protein-coupled receptors (GPCRs), innate immunity and regulatory mechanisms for inflammation, anti-inflammatory natural products and action mechanisms, and new target identification. While working in the U.S., Dr. Ye has received NIH funding for more than 20 years. He has published 160 scientific papers which have been cited for more than 9000 times. Dr. Ye has chaired an international panel for the IUPHAR nomenclature of formyl peptide receptors. He also served on NIH study sections and several professional journals, including an associate editor of American Journal of Physiology (Lung), editorial board of Molecular Pharmacology, section editor of the Journal of Immunology, and associate editor of Pharmacological Reviews.

Dr. Ye’s research group is seeking dedicated postdoctoral fellows and Ph.D. students. Interested candidates may contact the principal investigator at: richardye@umac.mo


Selected Publications

    For PubMed-listed papers, please used the URL http://www.ncbi.nlm.nih.gov/pubmed/?term=ye+rd

    Immunopharmacology and regulation of inflammation

    1. Xu, J., Liu, X., Wang, G., Cao, L., Qian, F., Taylor, S., Oh, M.-j., Levitan, I., Ye, R.D., Malik, A.B., Yang, T., Zhou, S., Zhao, Y., Suzuki, K., Tsukita, S. and Ishii M. (2014) Moesin and Myosin Phosphatase Confine Neutrophil Orientation in a Chemotactic Gradient. J. Exp. Med. 2015 Jan 19. pii: jem.20140508.
    2. Tang, H., Chen, J., Fraidenburg, D.R., Song, S., Sysol, J.R., Drennan, A.R., Offermanns, S., Ye,R.D., Bonini, M.G., Minshall, R.D., Garcia, J.G., Machado, R.F., Makino, A., Yuan, J.X. (2014) Deficiency of Akt1, but not Akt2, Attenuates the Development of Pulmonary Hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. doi:10.1152/ajplung. 00242. 2014.
    3. Yu, Y., and Ye, R.D. (2014) Microglial Abeta receptors in Alzheimer’s disease. Cell. Mol. Neurobio. Accepted for publication. DOI: 10.1007/s10571-014-0101-6
    4. Chen, MJ., Zhou, HB., Cheng, N., Qian, F., Ye, R.D. (2014) Serum amyloid A1 isoforms display different efficacy at Toll-like receptor 2 and formyl peptide receptor 2. Immunobiology 219:916-923.
    5. Sun, L., Zhu, Z., Cheng, N., Yan, Q., Ye, R.D. (2014) Serum amyloid A induces interleukin-33 expression through an IRF7-dependent pathway. Eur. J. Immunol. 44:2153-2164.
    6. Yan, Q., Sun, L., Zhu, Z., Wang, L., Li, S., Ye, R.D. (2014) Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages. Cell Signal. 26:1783-91.
    7. McDonald, P.P. and Ye, R. D. Detection of intact transcription factors in human neutrophils (2014) Methods Mol Biol. 1124:485-498.
    8. Yu, Y., Liu, J., Li, S.Q., Peng, L., Ye, R.D. (2014) Serum amyloid A differentially activates microglia and astrocytes via the PI3K pathway. J. Alzheimers Dis. 38:133-44. doi: 10.3233/JAD-130818.
    9. Chaudhuri, S., Gantner, B.N., Ye, R.D., Cianciotto, N.P., Freitag, N.E. (2013) The Listeria monocytogenes ChiA chitinase enhancesvirulence through suppression of host innate immunity. MBio. 4:e00617-12.
    10. Naikawadi, R.P., Cheng, N., Vogel, S. M., Qian, F., Wu, D., Malik, A. B., & Ye, R. D. (2012). A Critical Role for Phosphatidylinositol (3, 4, 5)-Trisphosphate–Dependent Rac Exchanger 1 in Endothelial Junction Disruption and Vascular Hyperpermeability.  Circulation Res. 111, 1517-1527.
    11. Deng, J., Wang, X., Qian, F., Vogel, S., Xiao, L., Ranjan, R., Park, H., Karpurapu, M., Ye, R.D., Park, G.Y., Christman, J.W. (2012) Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression. J. Immunol. 188:5734-5740. PMCID: PMC3358534.
    12. Sun, L., Ye, R.D. (2012) Role of G protein-coupled receptors in inflammation. Acta Pharmacol Sin. 33:342-50.
    13. Qian, F., Deng, J., Gantner, B.N., Flavell, R.A., Dong, C., Christman, J.W. and Ye, R.D. (2012) MAP Kinase Phosphatase 5 Protects Against Sepsis-induced Acute Lung Injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 32:768-777.
    14. Di, A., Gao, X.P., Qian, F., Kawamura, T., Han, J., Hecquet, C., Ye, R.D., Vogel, S.M., Malik, A.B. (2011) The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat. Immunol. 13:29-34.
    15. Ren, M., Guo, Q., Guo, L., Lenz, M., Qian, F., Koenen, R.R., Xu, H., Schilling, A.B., Weber, C., Ye, R.D., Dinner, A.R., Tang, W.J. (2010) Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J. 29:3952-3966.
    16. Feng, Q., Deng, J., Cheng, N., Welch, E.J., Zhang, Y., Malik, A.B., Flavell, R.A., Dong, C., Ye, R.D. (2009) A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 28:2896-2907.
    17. He, R.L., Zhou, J., Hanson, C., Chen, J., Cheng, N., and Ye, R.D. (2009) Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2. Blood. 113:429-437.
    18. Welch, E.J., Naikawadi, R.P., Li, Z., Lin, P., Ishii, S., Shimizu, T., Tiruppathi, C., Du, X., Subbaiah, P.V., and Ye, R.D. (2009) Opposing Effects of Platelet-activating Factor and Lyso-Platelet-activating Factor on Neutrophil and Platelet Activation. Mol. Pharm. 75:227-234.
    19. Cheng, N., He, R.L., Tian, J., Ye, P.P. and Ye, R.D. (2008) Cutting Edge:TLR2 is a functional receptor for acute-phase serum amyloid A.  J. Immunol. 181:22-26.
    20. Hu, G., Ye, R.D., Dinauer, M.C., Malik, A.B., and Minshall, R.D. (2008) Caveolin-1 dependent neutrophil activation in acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 294:L178-186 (editorial by Zemans, R. and Downey, G. P. appeared in AJP:LCMP 294:L175-L177, 2008). 
    21. Cheng, N., He, R., Tian, J., Dinauer, M.C., and Ye, R.D. (2007) A critical role of PKCd activation loop phosphorylation in fMet-Leu-Phe-induced phosphorylation of p47phox and rapid activation of NADPH oxidase. J. Immunol. 179:7720-7728.
    22. Chen, J., He, R., Minshall, R.D., Dinauer, M.C., and Ye, R.D. (2007) Characterization of a mutation in the PX domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. J. Biol. Chem. 282:30273-30284.
    23. He, R., Shepard, L.W., Chen, J., Pan, Z.K., and Ye, R.D. (2006) Serum amyloid A is an endogenous ligand that differentially induces interleukin-12 and interleukin-23. J. Immunol.177:4072-4079.

      G protein-coupled receptors and signal transduction

    24. Peng, L., Yu, Y., Liu, J., Li, SQ., He, HQ., Cheng, N., Ye, R.D. (2014) The chemerin receptor CMKLR1 is a functional receptor for amyloid beta peptide. J. Alzheimers Dis. DOI: 10.3233/JAD-141227. Epub 2014 Jul 30.
    25. Ye, R.D. (2014) STIM1 for stimulation of phagocyte NADPH oxidase. Blood 123:2129-30.
    26. Zhou, J.X., Liao, D., Zhang, S., Cheng, N., He, H.Q., Ye, R.D. (2014) Chemerin C9 peptide induces receptor internalization through a clathrin-independent pathway. Acta Pharmacol. Sin. 35:653-63.
    27. He, H.Q., Troksa, E.L., Caltabiano, G., Pardo, L., Ye, R.D. (2014) Structural Determinants for the Interaction of Formyl Peptide Receptor 2 with Peptide Ligands. J Biol Chem. 289, 2295-2306.
    28. Zhou, C., Zhou, Y., Wang, J., Feng, Y., Wang, H., Xue, J., Chen, Y., Ye, R.D., Wang, M.W. (2013) V101L of human formyl peptide receptor 1 (FPR1) increases the receptor affinity and augments the antagonism mediated by cyclosporins. Biochem J. 451:245-255.
    29. He, H.Q., Liao, D., Wang, Z.G., Wang, Z.L., Zhou, H.C., Wang, M.W., Ye R,D. (2013) Functional characterization of three mouse formyl Peptide receptors. Mol Pharmacol. 83:389-398.
    30. Gantner, B.N., Jin, H., Qian, F., Hay, N., He, B., Ye, R.D. (2012) The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin. J. Immunol. 189:3104-3111.
    31. Kwan, D.H., Yung, L.Y., Ye, R.D., Wong, Y.H. (2012) Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1. J Cell. Biochem. 113:3486-3497.
    32. Liu, X., Ma, B., Malik, A.B., Tang, H., Yang, T., Sun, B., Wang, G., Minshall, R.D., Li, Y., Zhao, Y., Ye, R.D. and Xu, J. (2012) Bidirectional Regulation of Neutrophil Migration by MAP Kinases. Nat. Immunol. 13:257-264. (R.D. Ye and J. Xu, co-corresponding authors).
    33. Hoeppner, Z.C., Cheng, N. and Ye, R.D. (2012) Identification of a nuclear localization sequence in b-arrestin1 and its functional implications.  J. Biol. Chem. 287:8932-8943.
    34. Qian, F., Le Breton, G.C., Chen, J., Deng, J., Christman, J.W., Wu, D., Ye, R.D. (2012) Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 in platelet secretion and aggregation. Arterioscler Thromb Vasc Biol. 32:768-777.
    35. Liu, A.M., Lo, R.K., Lee, M.M., Wang, Y., Yeung, W.W., Ho, M.K., Su, Y., Ye, R.D. and Wong, Y.H. (2010) Ga16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS). Cell Signal. 22:1448-1458.
    36. Ye, R.D. (2010) Biased agonism in chemoattractant signaling (editorial). J. Leuk. Biol. 87:959-961.
    37. Marty, C. and Ye, R.D. (2010) Heterotrimeric G protein signaling outside the realm of 7TM receptors (mini-review). Mol. Pharmacol. 78:12-18.
    38. Chen, J., Tang, H., Hay, N., Xu, J., Ye, R.D. (2010) Akt isoforms differentially regulate neutrophil functions. Blood 115:4237-4246.
    39. Nie, B., Cheng, N., Dinauer, M.C., Ye, R.D. (2010) Characterization of P-Rex1 for its role in fMet-Leu-Phe induced superoxide production in reconstituted COS-phox cells. Cell Signal. 22:770-782.                                               
    40. Gorovoy, M., Han, J., Pan, H., Welch, E., Neanu, R., Jia, Z., Vogel, S., Minshall, R., Ye, R.D., Malik, A.B., and Voyno-Yasenetskaya, T. (2009) LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs. Circ. Res. 105:549-556.
    41. Ye, R.D., Boulay, F., Wang, J.M., Dahlgren, C., Gerard, C., Parmentier, M., Serhan, C.N., and Murphy, P.M. (2009) International Union of Pharmacology: Nomenclature for the formyl peptide receptor (FPR) family.  Pharmacol. Rev. 61:119-161.
    42. Zhang, G., Han, J., Welch, E.J., Ye, R.D., Voyno-Yasenetskaya, T., Malik, A.B., Du, X. and Li, Z. (2009) LPS stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway.  J. Immunol. 182:7997-8004.
    43. Bair, A.M., Thippegowda, P.B., Freichel, M., Cheng, N., Ye, R.D., Vogel, S.M., Yu, Y., Flockerzi, V., Malik, A.B., and Tiruppathi, C. (2009) Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-B activation in endothelial cells through AMP-activated protein kinase and protein kinase C. J. Biol. Chem. 284:563-574.
    44. Yang, M., He, R.L., Benovic, J. L. and Ye, R.D. (2009) b-arrestin1 interacts with the G protein subunits b1g2 and promotes b1g2-dependent Akt signaling for NF-kB activation. Biochem. J. 417: 287-296.
    45. Li, L., Wang, J., Ye, R.D., Shi, G., Jin, H., Tang, X., and Yi, J. (2008) PML/ PML/RARa fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. J. Cell. Physiol. 217:486-493.
    46. Southgate, E.L., He, R.L, Gao, J.L., Murphy, P.M., Nanamori, M., and Ye, R.D. (2008) Identification of formyl peptides from Listeria monocytogenes and Staphylococcus aureus as potent chemoattractants for mouse neutrophils. J. Immunol. 181:1429-1437.
    47. Nanamori, M., Chen, J., Du, X.P. and Ye, R.D. (2007) Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: Potential roles in phosphorylation of t-SNARE complex proteins. J. Immunol. 178:416-427.
    48. Marty, C., Kozasa, T., Quinn, M.T., and Ye, R.D. (2006) Activation state-dependent interaction between Gai and p67phox. Mol. Cell. Biol. 26:5190-5200.

      Drug screening based on receptors and signal transduction

    49. Schepetkin, I.A., Kirpotina, L.N., Khlebnikov, A.I., Cheng, N., Ye, R.D., Quinn, M.T. (2014) Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones. Biochem Pharmacol. 92:627-641.
    50. Hu, Y., Cheng, N., Wu, H., Kang, S., Ye, R.D. and Cai, J. (2014) Design, synthesis and characterization of fMLF-mimicking Aapeptides. Chembiochem 15:2420-2426.
    51. Sieracki, N.A., Gantner, B.N., Mao, M., Horner, J.H., Ye, R.D., Malik, A.B., Newcomb, M.E., Bonini, M.G. (2013) Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin. Free Radic Biol Med. 61C:40-50.
    52. He, M., Cheng, N., Gao, W.W., Zhang, M., Zhang, Y.Y., Ye, R.D., Wang, M.W. (2011) Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury. Acta Pharmacol Sin. 32:601-610.
    53. Kirpotina, L.N., Khlebnikov, A.I., Schepetkin, I.A., Ye, R.D., Rabiet, M.J., Jutila, M.A., Quinn, M.T. (2010) Identification of Novel Small-Molecule Agonists for Human Formyl Peptide Receptors and Pharmacophore Models of their Recognition. Mol Pharmacol. 77:159-170.
    54. Cilibrizzi, A., Quinn, M.T., Kirpotina, L.N., Schepetkin, I.A., Holderness, J., Ye, R.D., Rabiet, M.J., Biancalani, C., Cesari, N., Graziano,A,, Vergelli, C., Pieretti, S., Dal Piaz, V., and Giovannoni, M.P. (2009) 6-Methyl-2,4-Disubstituted Pyridazin-3(2H)-ones: A novel class of small-molecule agonists for formyl peptide receptors. J. Med. Chem. 52:5044-57
    55. Edwards, B.S., Young, S.M., Ivnitsky-Steele, I., Ye, R.D., Prossnitz, E.R., and Sklar, L.A. (2009) High-content screening: flow cytometry analysis.  Methods Mol. Biol. 486: 151-165.
    56. Strouse, J.J., Young, S.M., Mitchell, H.D., Ye, R.D., Prossnitz, E.R., Sklar, L.A., and Edwards, B.S. (2009) A Novel Fluorescent Cross-Reactive Formylpeptide Receptor/Formylpeptide Receptor-Like 1 Hexapeptide Ligand. Cytometry A. 75A: 264-270.
    57. Young, S.M., Bologa, C.M., Fara, D., Bryant, B.K., Strouse, J.J., Arterburn, J.B., Ye, R.D., Oprea, T.I., Prossnitz, E.R., Sklar, L.A., and Edwards, B.S. (2009) Duplex high-throughput flow cytometry screen identifies two novel formylpeptide. Cytometry A. 75A: 253-263.
    58. Schepetkin, I.A., Korpotina, L.N., Tian, J., Khlebnikov, A.I., Ye, R.D., and Quinn, M.T. (2008) Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor a production.  Mol. Pharmacol. 74:392-402.
    59. Zhou, C., Zhang, S., Nanamori, M., Zhang, Y., Liu, Q., Li, N., Sun, M., Tian, J., Ye, P.P., Cheng, N., Ye, R.D., and Wang, M.W. (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol. Pharmacol. 72:976-983.
    60. Wan, H.X., Zhou, C., Zhang, Y., Sun, M., Wang, X., Yu, H., Yang, X., Ye, R.D., and Wang, M.W. (2007) Discovery of Trp-Nle-Tyr-Met as a novel agonist for human formyl peptide receptor-like 1. Biochem. Pharmacol. 74:317-326.
    61. Yan, P., Nanamori, M., Sun, M., Zhou, C., Cheng, N., Li, N., Zheng, W., Xiao, L., Xie, X., Ye, R.D. and Wang, M.W. (2006) The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J. Immunol.177:7050-7058.
    62. Tian, Q., Li, J., Xie, X., Sun, M., Sang, H., Zhou, C., An, T., Hu, L., Ye, R.D., Wang, M.W. (2005) Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol. Pharmacol. 68:1534-1542.
    63. Lin, P., Welch, E.J., Gao, X.-P., Malik, A.B., and Ye, R.D. (2005) Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cAMP. J. Immunol. 174:2981-2989.
    64. Nanamori, M., Cheng, X., Mei, J., Sang, H., Xuan, Y., Zou, C., Wang, M.W., and Ye, R.D. (2004) A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol. Pharmacol. 66:1213-1222.

 


Service to the scientific community

  • Council member, Chinese Pharmaceutical Society
  • Editorial Board, Molecular Pharmacology
  • Associate Editor, Pharmacological Reviews

Contact Details

Institute of Chinese Medical Sciences
University of Macau
Research Building N22, Room 1039
Macau, China
Tel: +853 8822-4690
Fax: +853 2884-1358
E-mail: richardye@umac.mo