Ruibing WANG
Assistant Professor, Institute of Chinese Medical Sciences

Fellow, Chao Kuang Piu College (CKPC)

 

Academic Qualifications

¡P         Ph.D. in Organic Chemistry, Queen¡¦s University, Canada

¡P         B.Sc. in Chemistry (Gifted Class), Jilin University, China

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Teaching

B.Sc. Courses

 

Wonders in Life Science and Health: Biomedical Science (ICMS 212)

Modern Drug Discovery (GEST021)

 

M.Sc. and Ph.D. Courses

 

CMED721 Emerging Materials in Clinical Medicine (M.Sc. Course)

CMED725 Across the Gap between Science and Industry (M.Sc. Course)

GRSC805 University Teaching II (Ph.D. Course)

CMED805 Advanced Pharmaceutics (Ph.D. Course)

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Research

Research Interests

¡P         Supramolecular Pharmaceutics/Medicine

 

We are interested in supramolecular interactions between macrocyclic molecules (such as cucurbiturils, cyclodextrins, pillararenes and calixarenes) and natural and/or synthetic drugs, with intentions to explore the beneficial roles of these macrocycles for enhancing water solubility, stability, transcellular activity, and ultimately therapeutic efficacy with reduced side effects. Our collaborators include colleagues here at UM, as well as external scientists from Canada, France, USA, Hong Kong and mainland China.

 

¡P         Supramolecular Biomaterials

 

We intend to incorporate high potency medical ingredients (e.g. natural and/or synthetic products) into stimuli-responsive supramolecularly self-assembled materials for various biomedical applications such as precision medicine, controlled drug release and interventional medicine for targeted cancer therapy.  These materials include natural polysaccharides and synthetic macrocycles. By placing real-world clinical applications as our study aim, we work closely with scientists and clinicians in the region and around the world.

 

¡P         Radiopharmaceuticals (and Radioactive/Heavy Elements Analysis and Control)

 

In collaboration with Sichuan University, we are also interested in controlling radioactive (mainly alphas) contamination of herbal medicine and cultivation environment. We design/synthesize materials that are able to isolate and separate these metal contaminants from herbs and/or soils; we also screen various phytoremediation strategies to help remove these contaminants from soils such that herbs may grow with minimized exposure to these heavy metal and radioactive contaminants. We are also actively introducing natural products into nuclear medicine by radiolabeling promising natural products and evaluating their in vitro and in vivo activities.

 

Dr. Ruibing Wang has multidisciplinary background and experience in Organic Chemistry, Supramolecular Chemistry/Materials, Radiopharmaceuticals and Interventional Medicine R&D. During his PhD studies at Queen¡¦s University, he was among the earliest group of researchers to look into a group of novel macrocyclic molecules, cucurbiturils, and their supramolecular encapsulation of various guest molecules including drug molecules for stability and water-solubility enhancement. Due to his excellent thesis work, he was nominated for ¡§Governor General Gold Medal¡¨ and received ¡§Queen¡¦s University Outstanding Thesis in Physical Sciences¡¨. After graduation with PhD study and a brief postdoctoral stay at Queen¡¦s, he moved to the Steacie Institute for Molecular Sciences at the National Research Council (NRC) of Canada as an Associate Research Officer for about two years, where he worked on fluorescent quantum dots development and studied their various applications including bioimaging. He was subsequently invited to join BTG International (Canada) as a Senior Scientist, where he had led various innovation and applied research projects around radiopharmaceuticals and interventional medicine development. Since late 2014, he has joined the University of Macau as an Assistant Professor in Pharmaceutical Sciences. His research interest has been mainly focused on supramolecular pharmaceutics and supramolecular medicine, and smart biomaterials, as well as radiopharmaceutical sciences. So far he has published more than 80 peer-reviewed SCI papers with a total citation of over 1300 times and an H-index of 21 (Google Scholar).

We are now looking for postgraduate students and research assistants who can participate in our research projects on pharmaceutical formulations and drug discovery. For further information, please contact Dr. WANG at rwang@umac.mo

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Publications

Representative peer-reviewed journal papers:

1.       Hang Yin, Frédéric Dumur, Yiming Niu, Mehmet Menaf Ayhan, Olivier Grauby, Wei Liu, Chunming Wang, Didier Siri, Roselyne Rosas, Alain Tonetto, Didier Gigmes, Ruibing Wang (correspondence author),* David Bardelang,* and Olivier Ouari,* ¡§A chameleonic dye adapts to various environments shining on macrocycles or peptide and polysaccharide aggregates,¡¨ ACS Applied Materials & Interfaces, 2017, DOI: 10.1021/acsami.7b06634, in press. IF: 7.504;

2.       Xue Yang, Qiaoxian Huang, David Bardelang, Chunming Wang, Simon Ming-Yuen Lee and Ruibing Wang (correspondence author),* ¡§Supramolecular alleviation of cardiotoxicity of a small-molecule kinase inhibitor,¡¨ Organic & Biomolecular Chemistry, 2017, DOI: 10.1039/C7OB01505D, in press. IF: 3.564;

To be Featured as a Cover Article;

3.       Cheng Gao, Fan Tang, Guiyi Gong, Jianxiang Zhang, Maggie P.M. Hoi, Simon M.Y. Lee,* and Ruibing Wang (correspondence author),* ¡§pH-responsive prodrug nanoparticles based on a sodium alginate derivative for selective co-release of doxorubicin and curcumin in tumor cells,¡¨ Nanoscale, 2017, 9, 12533. IF: 7.367;

4.       Yin Dou, Yue Chen, Xiangjun Zhang, Xiaoqiu Xu, Yidan Chen, Jiawei Guo, Dinglin Zhang, Ruibing Wang, Xiaohui Li, Jianxiang Zhang, ¡§Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis,¡¨ Biomaterials, 2017, 143, 93. IF: 8.402;

5.       Xue Yang, Shengke Li, Qingwen Zhang, Ying Zheng, David Bardelang, Lianhui Zhang, and Ruibing Wang (correspondence author),* ¡§Concealing the Taste of the Guinness World¡¦s Most Bitter Substance by a Synthetic Nanocontainer,¡¨ Nanoscale, 2017, 9, 10606. IF: 7.367;

6.       Yiming Niu, Qiu Li, Ruiyu Xie, Shang Liu, Ruibing Wang, Panfei Xing, Yuchen Shi, Yitao Wang, Lei Dong, Chunming Wang, ¡§Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: design of a glucomannan coating material,¡¨ Biomaterials, 2017, 139, 39. IF: 8.402;

7.       Shengke Li, Nan Jiang, Wen-Xuan Zhao, Yuanfu-Ding, Ying Zheng, Lian-Hui Zhang, Jun Zheng,* and Ruibing Wang (correspondence author),* ¡§An Eco-friendly In-situ Activable Antibiotic via Cucurbit[8]uril-Mediated Supramolecular Crosslinking of Branched Polyethylenimine,¡¨ Chemical Communications, 2017, 53, 5870. IF: 6.319;

8.       Wing Wai Yew, Denise Chan, Chi Leung, Ying Zhang, Ruibing Wang, Phoebe Ng, and Simon Lee, ¡§Can toxicities induced by antituberculosis drugs be better managed in diabetic patients?¡¨ European Respiratory Journal, 2017, 50: 1700409. IF: 10.569;

9.       Hang Yin, Linmin Chen, Binrui Yang, David Bardelang, Chunming Wang, Simon M. Y. Lee, and Ruibing Wang (correspondence author), ¡§Fluorescence enhancement and pKa shift of a Rho kinase inhibitor by a synthetic receptor,¡¨ ,¡¨ Organic & Biomolecular Chemistry, 2017, 15, 4336. IF: 3.564;

10.    Kit Ieng Kuok, Shengke Li, Ian W. Wyman, and Ruibing Wang (correspondence author),* ¡§Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients,¡¨  Annals of the New York Academy of Sciences, 2017, 1398, 108. IF: 4.706;

Invited Contribution

11.    Wanying Li, Hang Yin, David Bardelang, Jianbo Xiao, Ying Zheng* and Ruibing Wang (correspondence author),* "Supramolecular formulation of nitidine chloride can alleviate its hepatotoxicity and improve its anticancer activity,¡¨ Food and Chemical Toxicology, 2017, DOI:10.1016/j.fct.2017.02.022 , in press. IF: 3.778;

12.    Xue Yang, Wenxuan Zhao, Ziyi Wang, Ying Huang, Simon M. Y. Lee, Zhu Tao,* and Ruibing Wang (correspondence author),* ¡§Toxicity of hemimethyl-substituted cucurbit[7]uril,¡¨ Food and Chemical Toxicology, 2017, DOI:10.1016/j.fct.2017.01.003, in press.  IF: 3.778;

13.    Lin Sun, Zeyu Liu, Lun Wang, Dongmei Cun, Henry HY Tong, Ru Yan, Xin Chen, Ruibing Wang, and Ying Zheng, ¡§Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel,¡¨ Journal of Controlled Release, 2017, 254, 44. IF: 7.786;

14.    Qinghua Xie, Xia Li, Guanquan Wang, Xuan Hou, Yujun Wang, Hongbo Yu, Changfa Qu, Shunzhong Luo, Yali Cui, Chuanqin Xia, and Ruibing Wang (correspondence author),* ¡§Preparation and evaluation of 131I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer,¡¨ Journal of Radioanalytical and Nuclear Chemistry, 2017, 311, 1697. IF: 1.282;

15.    Cheng Gao, Fan Tang, Jianxiang Zhang, Simon M. Y. Lee,* and Ruibing Wang (correspondence author),* ¡§Glutathione-responsive nanoparticles from a sodium alginate derivative for selective release of doxorubicin in tumor cells,¡¨ Journal of Materials Chemistry B, 2017, 5, 2337. IF: 4.543;

16.    Tongkai Chen, Chuwen Li, Ye Li, Yi Xiang, Ruibing Wang, Simon Lee, Ying Zheng,* ¡§Small-sized mPEG-PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity,¡¨ ACS Applied Materials & Interfaces, 2017, 9, 9516. IF: 7.504;

17.    Shengke Li, Xue Yang, Yanan Niu, Greg Louis Andrew, David Bardelang, Xiuping Chen and Ruibing Wang (correspondence author),* ¡§Supramolecular Alleviation of Hepatotoxicity of Arecoline (Areca alkaloid) by a Synthetic Receptor,¡¨ ChemistrySelect, 2017, 2, 2219.

18.    Xing Zhou, Xiangjun Zhang, Songling Han, Yin Dou, Mengyu Liu, Lin Zhang, Jiawei Guo, Qing Shi, Genghao Gong, Ruibing Wang, Jiang Hu, Xiaohui Li, and Jianxiang Zhang, ¡§A Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route,¡¨ Nano Letters, 2017, 17, 1056. Impact factor: 13.779.

19.    Juan Cheng, Shibin Feng, Songling Han, Xiangjun Zhang, Yidan Chen, Xing Zhou, Ruibing Wang, Xiaohui Li, Houyuan Hu, and Jianxiang Zhang, ¡§Facile Assembly of Cost-Effective and Locally Applicable or Injectable Nanohemostats for Hemorrhage Control,¡¨ ACS Nano, 2016, 10, 9957. Impact factor: 13.334;

20.    Shengke Li, Yuan-Fu Ding, Hang Yin, Chunming Wang, David Bardelang, Lian-Hui Wang and Ruibing Wang (correspondence author),* ¡§Encapsulation of AGE-breaker Alagebrium by Cucurbit[7]uril Improved the Stability of both its Carbonyl £\-Hydrogen and Thiazolium C(2)-Hydrogen,¡¨ Chemistry - An Asian Journal, 2016, 11, 3126. Impact factor: 4.083;

21.    Quan Luo, Chunxi Hou, Yushi Bai, Ruibing Wang, and Junqiu Liu, ¡§Protein Assembly: Versatile Approaches to Construct Highly Ordered Nanostructures,¡¨ Chemical Reviews, 2016, 116, 13571. Impact factor: 47.928;

22.    Shengke Li, Ian Wyman, Chunming Wang, Yitao Wang, Donal Macartney,* and Ruibing Wang (correspondence author),* ¡§Inhibition of C(2)-H Activity on Alkylated Imidazolium Monocations and Dications Upon Inclusion by Cucurbit[7]uril,¡¨ Journal of Organic Chemistry, 2016, 81, 9494. Impact Factor: 4.849;

23.    Hang Yin, Runmiao Wang, Jianbo Wan, Ying Zheng, Defang Ouyang and Ruibing Wang (correspondence author),* ¡§Molecular encapsulations of histamine H2-receptor antagonists by cucurbit[7]uril: an experimental and computational study,¡¨ Molecules, 2016, 21, 1178. Impact factor: 2.861;

24.    Qixiong Zhang, Hui Tao, Yongyao Lin, Yin Hu, Huijie An, Dinglin Zhang, Shibin Feng, Houyuan Hu, Ruibing Wang, Xiaohui Li, Jianxiang Zhang,  ¡§Superoxide Dismutase/Catalase Mimetic Nanomedicine for Targeted Therapy of Inflammatory Bowel Disease,¡¨ Biomaterials, 2016, 105, 206. Impact factor: 8.402;

25.    Shengke Li, Judy Y. Chan, Yan Li, David Bardelang, Jun Zheng, Wing Wai Yew, Denise P. Chan, Simon MY Lee and Ruibing Wang (correspondence author),* ¡§Complexation of Clofazimine by Macrocyclic Cucurbit[7]uril Reduced its Cardiotoxicity without Affecting the Antimycobacterial Efficacy,¡¨ Organic & Biomolecular Chemistry, 2016, 14, 7563. Impact factor: 3.564;

26.    Xue Yang,   Ziyi Wang,   Yanan Niu,   Xiu-Ping Chen,  Simon Ming-Yuen Lee, and Ruibing Wang (correspondence author),* ¡§Influence of Supramolecular Encapsulation of Camptothecin by Cucurbit[7]uril: Reduced Toxicity and Preserved Anti-Cancer Activity,¡¨ MedChemComm, 2016, 7, 1392. Impact factor: 2.608;

27.    Yin Dou, Jiawei Guo, Yue Chen, Songling Han, Xiaoqiu Xu, Qing Shi, Yi Jia, Ya Liu, Youcai Deng, Ruibing Wang, Xiaohui Li, Jianxiang Zhang, ¡§Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice,¡¨ Journal of Controlled Release, 2016, 235, 48. Impact Factor: 7.786;

28.    Yang  Wang, Fang  Liu, Peng  Li, Chengwei  He, Ruibing  Wang, Huanxing Su, and Jianbo Wan, ¡§An Improved Pseudotargeted Metabolomics Approach Using Multiple Ion Monitoring with Time-Staggered Ion Lists Based on Ultra-High Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry," Analytica Chimica Acta, 2016, 927, 82. Impact factor: 4.950;

29.    Shengke Li, Hang Yin, Gudrun Martinz, Ian W. Wyman, David Bardelang, Donal H. Macartney, and Ruibing Wang (correspondence author),* ¡§Supramolecular encapsulation of benzocaine and its metabolite para-aminobenzoic acid by Cucurbit[7]uril,¡¨ New Journal of Chemistry, 2016, 40, 3484. Impact Factor: 3.269;

30.    Ning Pan, Long Li, Jie Ding, Shengke Li, Ruibing Wang (correspondence author),* Yongdong Jin,* Xiangke Wang, and Chuanqin Xia,* ¡§Preparation of graphene oxide-manganese dioxide for highly efficient adsorption and separation of Th(IV)/U(VI),¡¨ Journal of Hazardous Materials, 2016, 309, 107. Impact Factor: 6.065;

31.    Qing Li, Sheng-Chao Qiu, Kai Chen, Ying Zhang, Ruibing Wang, Ying Huang, Zhu Tao, Qian-Jiang Zhu, and Jing-Xin Liu, ¡§Encapsulation of alkyldiammonium ions within two different cavities of twisted cucurbit[14]uril¡¨, Chemical Communications, 2016, 52, 2589. Impact Factor: 6.319;

32.    Shengke Li, Hang Yin, Ian W. Wyman, Qingwen Zhang, Donal H. Macartney,* and Ruibing Wang (correspondence author),* ¡§Encapsulation of Vitamin B1 and its Phosphate Derivatives by Cucurbit[7]uril: Tunability of the Binding Site and Affinity by the Presence of Phosphate Groups¡¨, Journal of Organic Chemistry, 2016, 81, 1300. Impact Factor: 4.849;

33.    Pingping Xu, Shuai Tang, Luping Jiang, Lihua Yang, Kai Chen, Dinglin Zhang, Tingting Zhao, Yajun Dong, Wei He, Ruibing Wang, Jianxiang Zhang,* Zhiqing Liang, ¡§The nanomaterials-dependent modulation of dendritic cells and its effects on biological activities of contraception nanovaccines,¡¨ Journal of Controlled Release, 2016, 225, 252. Impact Factor: 7.786;

34.    Shengke Li, Huanxian Chen, Xue Yang, David Bardelang*, Ian Wyman, Jianbo Wan, Simon MY Lee, and Ruibing Wang (correspondence author),* "Supramolecular inhibition of neurodegeneration by a synthetic receptor", ACS Med. Chem. Lett., 2015, 6, 1174. Impact factor: 3.746;

Selected as a cover article and Featured Letter in the issue of Dec 2015

35.    Kai Chen, Xiaoqiu Xu, Jia Wei Guo, Xuelin Zhang, Songling Han, Ruibing Wang, Xiaohui Li, and Jianxiang Zhang, ¡§Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry,¡¨ Biomacromolecules, 2015, 16, 3574. Impact factor: 5.246;

36.    Huanxian Chen, Judy Yuet-Wa Chan, Shengke Li, Jessica J Liu, Ian Wyman, Simon Ming-Yuen Lee, Donal H Macartney, and Ruibing Wang (correspondence author),* ¡§In vivo Reversal of General Anesthesia by Cucurbit[7]uril with Zebrafish Models,¡¨ RSC Advances, 2015, 5, 63745. Impact factor: 3.108;

Highlighted by Chemistry World research news (Aug. 6 2015):

http://www.rsc.org/chemistryworld/2015/08/reverse-anaesthesia-cucurbituril-zebrafish

Featured by TDM news (Aug. 31, 2015) https://www.facebook.com/Canal.Macau/videos/852296681553156/?pnref=story

37.    Xiaoqing Miao, Ye Li, Ian Wyman, Simon M. Y. Lee, Donal H. Macartney, Ying Zheng,* and Ruibing Wang (correspondence author),* ¡§Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril,¡¨ MedChemComm, 2015, 6, 1370. Impact factor: 2.608;

38.    Shengke Li, Xiaoqing Miao, Ian W. Wyman, Ye Li, Ying Zheng, Yitao Wang, Donal H. Macartney* and Ruibing Wang (correspondence author),* ¡¨High-Affinity Host-Guest Complex of Cucurbit[7]uril with a Bis(thiazolium) Salt,¡¨ RSC Advances, 2015, 5, 56110. Impact factor: 3.108;

39.    Huanxian Chen, Judy Yuet-Wa Chan, Xue Yang, Ian Wyman, David Bardelang, Donal H Macartney, Simon Ming-Yuen Lee,* Ruibing Wang (correspondence author),* ¡§Developmental and organ-specific toxicity of cucurbit [7] uril: in vivo study on zebrafish models,¡¨ RSC Advances, 2015, 5, 30067. Impact factor: 3.108;

40.    Duo Jiang, Li Liu, Ning Pan, Fuqiang Yang, Shengke Li, Ruibing Wang (correspondence author),* Ian W Wyman, Yongdong Jin,* and Chuanqin Xia,* ¡§The separation of Th (IV)/U (VI) via selective complexation with graphene oxide,¡¨ Chemical Engineering Journal, 2015, 271, 147. Impact Factor: 6.216;

Book Chapters

1.       Hui Liu, Fan-Cheng Meng, Ying Wang, Ruibing Wang, Wen-Cai Ye, and Qing-Wen Zhang, ¡§Triterpenoids and their Saponins from Ilex asprella: Types and Biological Studies,¡¨ in Saponins: Typs, Sources and Research, Candice Greene (Ed.), Nova Science Publishers, 2016.

2.       Y. Chang, F.-C. Meng, R. Wang, C. Wang, X.-Y. Lu, Q.-W. Zhang, Chemistry, ¡§Bioactivity, and the Structure-Activity Relationship of Cephalotaxine-Type Alkaloids From Cephalotaxus sp.,¡¨ in Studies in Natural Products Chemistry, Atta-ur-Rahman (Ed.), Volume 53 (1st Ed.), Elsevier, 2017.

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Professional Affiliation

Founding Member and Vice President, Macau Society of Nuclear Medicine and Molecular Imaging (MSNMMI), since 2016

Council Member, the 1st Board of Specialty Committee of TCM Network Pharmacology of World Federation of Chinese Medicine Societies, since 2015

Member, Society of Interventional Radiology

Member, Society of Nuclear Medicine and Molecular Imaging

Member, International Society for Chinese Medicine

Member, International Society of Quality Research of Chinese Medicine

Member, Macao Society for Promotion of Science and Technology

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Professional Community Service

Editor, Chinese Journal of Chemical Education (Chinese Core journal), Jan 2017-Present

Editor, Journal of Nanomaterials (impact factor 1.61), February 2012-Present

Editor, Journal of Analytical Methods in Chemistry (impact factor 0.95), January 2011-January 2012

Review Editor in Medicinal and Pharmaceutical Chemistry, Frontiers in Chemistry, Dec 2015-Present

Reviewer for Nature Communications, Scientific Reports, ACS and RSC Journals, Food and Chemical Toxicology, Peptides, Sensors and Actuators, Phytochemistry Reviews, PCCP, ChemistrySelect, Molecules, Chemical Engineering Journal, CrystEngComm, Journal of Inclusion Phenomena and Macrocyclic Chemistry etc.

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Contact Details

Institute of Chinese Medical Sciences

SKL of Quality Research in Chinese Medicine

University of Macau, N22

Avenida da Universidade, Taipa, Macau
Email: rwang@umac.mo
Tel: +853-8822-4689