Meiwan CHEN  陳美婉

Assistant Professor

 

Academic Qualifications | Teaching | Research | Selected Publications | Qualifications | Contact Details


Academic Qualifications


Teaching


Research Interests

 

Dr. Meiwan Chen’s research focuses on biomaterial and nanomedicine, especially on development of targeted drug delivery systems for cancer therapy. The research ranges from design and synthesis of novel lipidic and polymeric carriers to mechanistic understanding of delivery barriers and to in vivo studies of relevant tumor models. The emphasis is on improving the efficacy of chemotherapeutics that have poor water-solubility, fast metabolism, non-selectivity, and drug resistance. Leveraging on the expertise and resources of the SKL of Quality Research in Chinese Medicine at the University of Macau, the lab also develops nanomedicines combining Chinese and Western medicinal compounds for synergistic effects.

 

Dr. Chen as a PI has been awarded over 10 major research grants, from agencies including the National Natural Science Fund of China (NSFC), Macao Science and Technology Development Fund (FDCT), Research Fund of the University of Macau, International S&T Cooperation Program of Guangdong Province, and Program from Key laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences and State Key Laboratory of Natural and Biomimetic Drugs, Peking University. Since 2010, Dr. Chen has published more than 80 peer-reviewed SCI papers as the first or corresponding author, many of which appear in top-tier pharmaceutics and biomaterials journals including ACS Nano, Advanced Functional Materials, Biomaterials, Journal of Controlled Release, Molecular Pharmaceutics, and Pharmaceutical Research. Her academic achievements have been recognized by 1st/2nd Macao Science and Technology Awards - Natural Science Award (2012/2014). She (co-)supervises more than 10 PhD/MSc graduates: one student received the 9th China Youth Science and Technology Innovation Award; five students received the Macao Science and Technology Award-Scientific and Technological R&D Awards for Postgraduates; and more than twenty conference awards.

 

Macao Science and Technology Awards

 


Publications

Selected International Peer-reviewed Journal articles (*co-/corresponding author)

1.    LZ Feng, DL Tao, ZL Dong, Q Chen, Y Chao, Z Liu*, MW Chen*. Near-infrared Light Activation of Quenched Liposomal Ce6 for Synergistic Cancer Phototherapy with Effective Skin Protection. Biomaterials, 2016, DOI: 10.1016/j.biomaterials.2016.11.027. (IF: 8.387)

 

2.    Y Yang, JJ Liu, C Liang, LZ Feng, TT Fu, ZL Dong, Y Chao, YG Li, G Lu*MW Chen*, Z Liu*. Nanoscale Metal-Organic Particles with Rapid Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy. ACS Nano, 2016, 10(2): 2774-2781. (IF: 13.334)

 

3.    YE Cai, JM Zhang, Nelson G. Chen, Z Shi, JG Qiu, CW He*, MW Chen*. Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins. Medicinal Research Reviews, 2016, DOI: 10.1002/med.21422. (IF: 9.135)

 

4.    LZ Feng, L Cheng, ZL Dong, DL Tao, TE Barnhart, WB Cai*, MW Chen*, Z Liu*. Theranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic Therapy. ACS Nano, 2016, DOI: 10.1021/acsnano.6b07525. (IF: 13.334)

 

5.    JM Zhang, RE Chen, XF Fang, FQ Chen, YT Wang*, MW Chen*. Nucleolin Targeting AS1411 Aptamer Modified pH-Sensitive Micelles for Enhanced Delivery and Antitumor Efficacy of Paclitaxel. Nano Research, 2015, 8(1): 201-218. (IF: 8.893)

 

6.    Y Yang, Y Chao, JJ Liu, ZL Dong, WW He, R Zhang, K Yang, MW Chen*, Z Liu*. Core-shell & Co-doping Nanoscale Metal-Organic Particles (NMOPs) via Post-synthesis Cation Exchange for Multimodal Imaging and Synergistic Thermo-radiotherapy. NPG Asia Materials, (2017) 9, e344; doi:10.1038/am.2016.205. (IF: 8.772)

 

7.    LZ Feng, M Gao, DL Tao, Q Chen, HR Wang, ZL Dong, MW Chen*, Z Liu*. Cisplatin-prodrug-constructed liposomes as a versatile theranostic nano-platform for bimodal imaging guided combination cancer therapy. Advanced Functional Materials, 2016, 26(13), 2207-2217. (IF: 11.382)

 

8.    Y Yang, JJ Liu, XQ Sun, LZ Feng, WW Zhu, Z Liu*, MW Chen*. Near-infrared Light-activated Cancer Cell Targeting and Drug Delivery with Aptamer Modified Nanostructures. Nano Research, 2016, 9(1): 139-148. (IF: 8.893)

 

9.    FQ Chen, JM Zhang, L Wang, YT Wang*, MW Chen*. Tumor pHe-triggered charge-reversal and redox-responsive nanoparticles for docetaxel delivery in hepatocellular carcinoma treatment. Nanoscale, 2015, 7(38): 15763-15779. (IF: 7.76)

 

10. Y Yang, T Liu, L Cheng, GS Song, Z Liu*, MW Chen*. MoS2-Based Nanoprobes for Detection of Silver Ions in Aqueous Solutions and Bacteria. ACS Applied Materials & Interfaces, 2015, 7(14): 7526-7533. (IF: 7.145)

 

11. SP Wang, JE Qiu, Z Shi*, YT Wang, MW Chen*. Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer. Biotechnology Advances, 2015, 33(1): 224-241. (IF: 9.848)

 

12. SP Wang, YQ Xu, HF Chan, HW Kim, YT Wang, KW Leong*, MW Chen*. Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy. Journal of Controlled Release, 2016, 240: 454-464. (IF: 7.441)

 

13. Y Yang, SP Wang, YT Wang, XH Wang*, Q Wang*, MW Chen*. Advances in self-assembled chitosan nanomaterials for drug delivery. Biotechnology Advances, 2014, 32(7): 1301-1316. (IF: 9.848)

 

14. JJ Liu, Y Yang, WW Zhu, X Yi, ZL Dong, XN Xu, MW Chen, K Yang, G Lu, LX Jiang*, Z Liu*. Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment. Biomaterials, 2016, 97: 1-9. (IF: 8.387)

 

15. ZQ Lin, D Mei, MW Chen, YT Wang, XH Chen, ZY Wang, B He, H Zhang, XQ Wang, WB Dai*, YX Yin*, and Q Zhang*. A comparative study of thermo-sensitive hydrogel with water-insoluble paclitaxel in molecule, nanocrystal and microcrystal dispersions. Nanoscale, 2015, 7(36): 14838-14847. (IF: 7.76)

 

16. JM Zhang, J Hu, HF Chan, M Skibba, G Liang*, MW Chen*. iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12(5): 1303-1311. (IF: 5.671)

 

17. SP Wang, JM Zhang, YT Wang*, MW Chen*. Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of Doxorubicin and miR-542-3p for triple negative breast cancer therapy. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12(2): 411-420. (IF: 5.671)

 

18. J Chen, H Liang, L Lin, ZP Guo, PJ Sun, MW Chen, HY Tian*, MX Deng*, XS Chen*. Gold-nanorods-based gene carriers with the capability of photoacoustic imaging and photothermal therapy. ACS Applied Materials & Interfaces, 2016, 8(46): 31558-31566. (IF: 7.145)

 

19. SP Wang, RE Chen, J Morott, MA Repka, YT Wang*, MW Chen*. mPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Expert Opinion on Drug Delivery, 2015, 12(3): 361-373. (IF: 5.434)

 

20. JM Zhang, YB Li, W Gao, MA Repka, YT Wang*, MW Chen*. Andrographolide-loaded PLGA-PEG-PLGA micelles to improve its bioavailability and anticancer efficacy. Expert Opinion on Drug Delivery, 2014, 11(9): 1367-1380. (IF: 5.434)

 

21. XJ Jia, LS Ma, P Li, MW Chen*, CW He*. Prospects of Poria cocos polysaccharides: isolation process, structural features and bioactivities. Trends in Food Science & Technology, 2016, 54: 52-62. (IF: 5.15)

 

22. SP Wang, JM Zhang, MW Chen*, YT Wang*. Delivering flavonoids into solid tumors using nanotechnologies. Expert Opinion on Drug Delivery, 2013, 10(10): 1411-1428. (IF: 5.434)

 

23. GY Zhou, YM Xu, MW Chen, D Cheng*, XT Shuai*. Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery. Polymer Chemistry, 2016, 7(23): 3857-3863. (IF: 5.687)

 

24. J Gong, MW Chen, Y Zheng, SP Wang, YT Wang*. Polymeric micelles Drug Delivery System in Oncology. Journal of Controlled Release, 2012, 159(3): 312-323. (IF: 7.441)

 

25. YB Li, ZQ Wang, X Yan, MW Chen, JL Bao, GS Wu, ZM Ge, DM Zhou, YT Wang*, RT Li*. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer Letters, 2013, 340(1): 88-96. (IF: 5.992)

 

26. H Chen, MW Chen, XH Wang*, RC Sun*. Self-assembled conjugated polymer/carboxymethyl chitosan grafted poly(p-dioxanone) nanomicelles and their use in functionalized indicator paper for fast and visual detection of a banned food dye. Polymer Chemistry, 2014, 5: 4251-4258. (IF: 5.687)

 

27. ZS Wu, G Wan, CC Su, MW Chen, XY Shi, DH Liang*, YJ Qiao*. Nano-analysis of triptolide liposomes for potential therapy of prostate cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12(2): 449-575. (IF: 5.671)

 

28. QW Jiang, KJ Cheng, XL Mei, JG Qiu, XJ Zhang, YQ Xue, WM Qin, Y Yang, DW Zheng, Y Chen, MN Wei, X Zhang, M Lv, MW Chen, X Wei, Z Shi*. Synergistic Anticancer Effects of Triptolide and Celastrol, Two Main Compounds from Thunder God Vine.  Oncotarget, 2015, 6(32): 32790-32804. (IF: 5.008)

 

29. XB Fang, YQ Xu, HF Chan, CM Wang, Q Zheng, F Xiao, MW Chen*. A Redox-Sensitive and RAGE-Targeting Nanocarrier for Hepatocellular Carcinoma Therapy. Molecular Pharmaceutics, 2016, 13(11): 3613-3625. (IF: 4.342)

 

30. QW Jiang, MW Chen, KJ Cheng, PZ Yu, X Wei, Z Shi*. Therapeutic potential of steroidal alkaloids in cancer and other diseases. Medicinal Research Reviews, 2016, 36(1): 119-143. (IF: 9.135)

 

31. LD Zou, FQ Chen, JL Bao, SP Wang, L Wang, MW Chen*, CW He*, YT Wang. Preparation, Characterization, and Antitumor Efficacy of Evodiamine Loaded PLGA Nanoparticles. Drug Delivery, 2016, 23(3): 908-916. (IF: 4.843)

 

32. YE Cai, YQ Xu, HF Chan, XB Fang, CW He, MW Chen*. Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy. Molecular Pharmaceutics, 2016, 13(3): 699-709. (IF: 4.342)

 

33. YE Cai, WJ Zhang, ZR Chen, Z Shi*, CW He, MW Chen*. Recent Insights into the Biological Activities and Drug Delivery Systems of Tanshinones. International Journal of Nanomedicine, 2016, 11: 121-130. (IF: 4.32)

 

34. YL Liu, YQ Xu, MH Wu, LJ Fan, CW He, JB Wan, P Li, MW Chen*, H Li*. Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity. International Journal of Nanomedicine, 2016, 11: 3167-3178. (IF: 4.32)

 

35. XB Fang, JM Zhang, X Xie, D Liu, CW He, JB Wan, MW Chen*, pH-Sensitive Micelles Based on Acid-Labile Pluronic F68-Curcumin Conjugates for Improved Tumor Intracellular Drug Delivery, International Journal of Pharmaceutics, 2016, 502(1-2): 28-37. (IF: 3.994)

 

36. L Wang, X Xie, D Liu, XB Fang, P Li, JB Wan, CW He, MW Chen*. iRGD-mediated reduction-responsive DSPE–PEG/LA–PLGA–TPGS mixed micelles used in the targeted delivery and triggered release of docetaxel in cancer. RSC Advances, 2016, 6(34): 28331-28342. (IF: 3.289)

 

37. YE Cai, SP Wang, MH Wu, JK Tsosie, X Xie, JB Wan, CW He, HY Tian, XS Chen, MW Chen*. PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer. RSC Advances, 2016, 6(42): 35318-35327. (IF: 3.289)

 

38. FQ Chen, JM Zhang, Y He, XF Fang, YT Wang*, MW Chen*. Glycyrrhetinic Acid-decorated and Reduction-sensitive Micelles to Enhance Bioavailability and Anti-hepatocellular Carcinoma Efficacy of Tanshinone IIA. Biomaterials Science, 2016, 4(1): 167-182. (IF: 3.614)

 

39. J Hu, XJ Jia, XB Fang, P Li, CW He*, MW Chen*. Ultrasonic extraction, antioxidant and anticancer activities of novel polysaccharides from Chuanxiong rhizome.  International Journal of Biological Macromolecules, 2016, 85: 277-284. (IF: 3.138)

 

40. YE Cai, ZQ Sun, XB Fang, XF Fang, F Xiao*, YT Wang, MW Chen*. Synthesis, Characterization, and Anticancer Activity of Pluronic F68-Curcumin Conjugate Micelles. Drug Delivery, 2016, 23(7): 2587-2595. (IF: 4.843)

 

41. SP Wang, Y Yang, YT Wang*, MW Chen*. Gambogic acid-loaded pH-sensitive mixed micelles for overcoming breast cancer resistance. International Journal of Pharmaceutics, 2015, 495(2): 840-848. (IF: 3.994)

 

42. RE Chen, SP Wang, JM Zhang, MW Chen*, YT Wang*. Aloe-emodin loaded solid lipid nanoparticles: formulation design and in vitro anti-tumor study. Drug Delivery, 2015, 22(5): 666-674. (IF: 4.843)

 

43. WJ Ge, D Li, MW Chen, XH Wang*, SJ Liu, RC Sun. Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles. Carbohydrate polymers, 2015, 117: 169-176. (IF: 4.219)

 

44. JM Zhang, M Zhang, J Ji, XF Fang, X Pan, YT Wang*, CB Wu, MW Chen*. Glycyrrhetinic acid-mediated polymeric drug delivery targeting the acidic microenvironment of hepatocellular carcinoma. Pharmaceutical Research, 2015, 32(10): 3376-3390. (IF: 3.26)

 

45. SP Wang, YY Hu, W Tan, X Wu, RE Chen, JL Cao, MW Chen*, YT Wang*. Compatibility art of Traditional Chinese Medicine: From the perspective of Herb pairs. Journal of Ethnopharmacology, 2012, 143(2): 412-423. (IF: 3.055)

 

46. MW Chen, JM Zhang, YF Lai, SP Wang, P Li, J Xiao, CM Fu, H Hu, YT Wang*. Analysis of Pogostemon cablin from pharmaceutical research to market performances. Expert Opinion on Investigational Drugs, 2013, 22(2): 245-257. (IF: 4.408)

 

47. SP Wang, L Wang, MW Chen*, YT Wang*. Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression. Chemico-Biological Interactions, 2015, 235: 76-84. (IF: 2.618)

 

48. JM Zhang, YB Li, XF Fang, DM Zhou, YT Wang*, MW Chen*. TPGS-g-PLGA/Pluronic F68 mixed micelles for Tanshinone IIA delivery in cancer therapy. International Journal of Pharmaceutics, 2014, 476(1-2): 185-198. (IF: 3.994)

 

49. YY Hu, SP Wang, X Wu, JM Zhang, RE Chen, MW Chen*, YT Wang*. Chinese herbal medicine-derived compounds for cancer therapy: A focus on hepatocellular carcinoma. Journal of Ethnopharmacology, 2013, 149(3): 601-612. (IF: 3.055)

 

50. SP Wang, X Wu, M Tan, J Gong, BL Bian, MW Chen*, YT Wang*. Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy. Journal of Ethnopharmacology, 2012, 140(1): 33-45. (IF: 3.055)

 

Book Chapters

1.           SP Wang, MW Chen, Q Zhou, HK Chan. The chapter of “Novel formulations and drug delivery systems for phytotherapies” in the book “Phytotherapies: Efficacy, Safety and Regulation”. (Wiley, USA, 2014)

 

2.           XH Wang, YZ Guo, HQ Zhong, MW Chen, RC Sun. The chapter of "Preparation, self-assembly and application of amphiphilic cellulose-based graft copolymers" in the book "Cellulose-Based Graft Copolymers: Structure and Chemistry". (Taylor& Francis-CRC Press Publisher, 2014)

 

3.           In the book “Modern technology and progress on anti-tumor Chinese medicine”. (Chapter 4) (Beijing: People’s Medical Publishing House, 2012)

 

Patents

  1. CB Wu, MW Chen. Studies on the thermo-sensitive spraying gel containing silver nanoparticles for vaginal application. PRC patent number:  200810029201.9.

 

  1. CB Wu, MW Chen. Studies on the aerosol foam of thermo-sensitive gel containing silver nanoparticles for women application. PRC patent number: ZL200910037397.0.

 

  1. YT Wang, RT Li, YB Li, MW Chen, ZM Ge, X Yan. Application of IC-4 for anti-neovascularization. PRC patent number: 201210100743.7.

 

Selected Awards and Honors

1.       XB Fang, MW Chen*. Stimuli-responsive Nanoparticle Drug Delivery Systems Based on Poloxamer 188. The 1st ICMS Postgraduate Student Academic Forum, Macau, 11 December 2015, First Prize.

 

  1. LZ Feng, Z Liu*, MW Chen*. Cisplatin-Prodrug-Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy. The 30th Academic Annual Conference of Chinese Chemical Society, Dalian, 1-4 July 2016, Excellent Poster Award.

 

  1. YQ Xu, MW Chen*. Targeting Nanocarriers for Cancer Therapy: from Cells to Organelles. The 2nd ICMS Postgraduate Student Academic Forum, Macau, 9 December 2016, Excellent Prize.

 

  1. GJ Song, YX Tian*, MW Chen*. A Ratiometric Fluorescence Phobe for Sensing Mitochondria Bisulfite. The 2nd ICMS Postgraduate Student Academic Forum, Macau, 9 December 2016, Nominee Prize.

 

  1. Y Yang.  Liu’s lab Annual Research Meeting. Soochow, 12 August 2016, Annual Creative research Award.

 

  1. JM Zhang, YT Wang*, MW Chen*. pH-sensitive polymer nanoparticles for co-delivery of doxorubicin and curcumin in treating cancer via enhanced pro-apoptotic and anti-angiogenic activities. IGPS2015&AAPS-SYSU Symposium, Guangzhou, 21-23 August 2015, Oral Presentation Third Prize & Excellent Poster Award.

 

  1. YQ Xu, MW Chen*. Co-delivery of paclitaxel and tetrandrine via iRGD peptide conjugated nanoparticles for overcoming multidrug resistance in cancer cells. IGPS2015&AAPS-SYSU Symposium, Guangzhou, 21-23 August 2015, Excellent Poster Award.

 

  1. SP Wang, MW Chen, YT Wang. The world of Chinese medicine, Chinese medicine of the world. 9th China Youth Science and Technology Innovation Award.

 

  1. JM Zhang, J Hu, G Liang*, YT Wang, MW Chen*. iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy. 2014 Chinese Pharmaceutical Conference. Changsha, 19-21 September 2014, Postgraduate Forum (Third Class Prize).

 

  1. SP Wang, Y Yang, JM Zhang, YT Wang*, MW Chen*. Gambogic Acid loaded pH-sensitive Mixed Micelles for Overcoming Breast Cancer Resistance. 2014 Chinese Pharmaceutical Conference. Changsha, 19-21 September 2014, Excellent Poster Award (Second Class Prize).

 

  1. YQ Xu, SP Wang, YT Wang, MW Chen*. Preparation, Characterization, and In Vitro Evaluation of Curcumin-Niosome. 2014 Chinese Pharmaceutical Conference. Changsha, 19-21 September 2014, Excellent Poster Award (Third Class Prize).

 

  1. YE Cai, XB Fang, JM Zhang, YY Zhu, YT Wang, MW Chen*. Synthesis, Characterization and Anticancer Activity of Pluronic F68-Curcumin Conjugate Micelles. 2014 Chinese Pharmaceutical Conference. Changsha, 19-21 September 2014, Excellent Poster Award (Third Class Prize).

 

  1. JM Zhang, MW Chen*, YT Wang*. Nucleolin targeting AS1411 aptamer modified pH-Sensitive micelles for paclitaxel delivery in cancer therapy. 13th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, 27-29 August 2014, Travel Grant Award.

 

  1. JM Zhang, MW Chen*, YT Wang*. N-Boc-Histidine-capped glycyrrhetinic acid-modified polyethylene glycol/poly lactic-co-glycolic acid dual mediated functional nanoparticles for targeted liver tumor chemotherapy. 3rd Nano Today Conference. Singapore, 8-11 December 2013, Travel Grant Award.

 

  1. JM Zhang, SP Wang, FQ Chen, L Wang, MW Chen*, YT Wang*. Smart drug delivery systems for Chinese medicine in liver cancer chemotherapy. TCM Innovation and Development Forum. Chengdu, 26-27 October 2013, Excellent Paper Award & “Young Scientist Excellence” Third Award.

 

  1. SP Wang, JM Zhang, MW Chen*, YT Wang*. Developing novel anti-tumor drug delivery systems based on Chinese medicine, 4th International conference on modernization of Chinese medicine. Chengdu, 26-27 September 2013, Excellent Paper Award.

 

  1. JM Zhang, MW Chen*, YT Wang*. Design of smart nanoparticles with multiple mediated mechanisms for liver cancer chemotherapy, 12th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Austria, 27-29 August 2013, Travel Grant Award and Presentation.

 

  1. JM Zhang, MW Chen*, YT Wang*. Smart nanoparticle carriers by dual mechanisms mediated for Chinese medicine in liver cancer chemotherapy. AAPS@China Symposium. Hong Kong, 17-18 August 2013, Podium Presentation Award.

Qualifications


Contact Details

Institute of Chinese Medical Sciences
University of Macau
Avenida da Universidade, Taipa, Macao SAR

Room 6012, 6F, N22
Tel: (853) 8822-4675
Fax: (853) 2884-1358

E-mail: mwchen@umac.mo