Pui Man HOI 許貝文
Associate Professor

Academic Qualifications | Teaching | Research | Selected Publications | Contact Details

Academic Qualifications

  • BSc (Hon), University College London, U.K.
  • PhD, Pharmacology, University of Cambridge, U.K.



BSc Courses

  • CMED701 Pharmacology and Safety Evaluation

MSc Courses

  • CMED827 Research Writing
  • CMED804 Advanced Pharmacokinetics



Research Interests

  • Drug discovery and drug screening
  • Cardiovascular and cerebrovascular pharmacology
  • Angiogenesis and endothelial dysfunctions
  • Metabolic Disorders

Selected Publications


  1. Yang, B. R., Cheung, K. K., Zhou, X., Xie, R. F., Cheng, P. P., Wu, S., Zhou, Z. Y., Tang, J. Y., Hoi, P. M., Wang, Y. H. & Lee, S. M.* Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis. Journal of ethnopharmacology 181, 50-58, doi:10.1016/j.jep.2016.01.022 (2016).

  2. Vong, C. T., Tseng, H. H., Kwan, Y. W., Lee, S. M. &  Hoi, P. M.* (Corresponding author) Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Frontiers in pharmacology 7, 67, doi:10.3389/fphar.2016.00067 (2016).

  3. Seto, S. W.*, Kiat, H., Lee, S. M., Bensoussan, A., Sun, Y. T., Hoi, M. P. & Chang, D. Zebrafish models of cardiovascular diseases and their applications in herbal medicine research. Eur J Pharmacol, doi:10.1016/j.ejphar.2015.10.031 (2015).

  4. Li, S., Zhou, X. L., Dang, Y. Y., Kwan, Y. W., Chan, S. W., Leung, G. P., Lee, S. M. & Hoi, P. M.* (Corresponding author)  Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta 1850, 373-384, doi:10.1016/j.bbagen.2014.10.023 (2015).

  5. Li, S., Dang, Y., Zhou, X., Huang, B., Huang, X., Zhang, Z., Kwan, Y. W., Chan, S. W., Leung, G. P., Lee, S. M. & Hoi, P. M.* (Corresponding author) Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Sci Rep 5, 16815, doi:10.1038/srep16815 (2015).

  6. Hoi, P. M.* (Corresponding author), Li, S., Vong, C. T., Tseng, H. H., Kwan, Y. W. & Lee, S. M. Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors. Methods 71, 85-91, doi:10.1016/j.ymeth.2014.09.004 (2015).

  7. Cui, G., Shan, L., Guo, L., Chu, I. K., Li, G., Quan, Q., Zhao, Y., Chong, C. M., Zhang, Z., Yu, P., Hoi, P. M.* (Corresponding author), Sun, Y., Wang, Y. & Lee, S. M. Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy. Sci Rep 5, 10353, doi:10.1038/srep10353 (2015).

  8. Tam, I. L., Wang, Y. & Hoi, P. M.* (Corresponding author) Mogrosides extract from Siraitia grosvenori enhances the endothelial function of rat mesenteric arteries in hyperglycemic environments. Pharmacology and Clinics of Chinese Materia Medica  30, 97-100 (2014).

  9. Li, S., Dang, Y. Y., Oi Lam Che, G., Kwan, Y. W., Chan, S. W., Leung, G. P., Lee, S. M. & Hoi, P. M.* (Corresponding author) VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol 280, 408-420, doi:10.1016/j.taap.2014.09.005 (2014).

  10. Li, Y. B., Zhong, Z. F., Chen, M. W., Bao, J. L., Wu, G. S., Zhang, Q. W., Lee, S. M., Hoi, P. M.* (Corresponding author) & Wang, Y. T.* Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med 2013, 851714, doi:10.1155/2013/851714 (2013).

  11. Cui, G., Shan, L., Hung, M., Lei, S., Choi, I., Zhang, Z., Yu, P., Hoi, P. M.* (Corresponding author), Wang, Y.* & Lee, S. M.* A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Int J Cardiol 168, 1349-1359, doi:10.1016/j.ijcard.2012.12.012 (2013).

  12. Zhou, X., Chan, S. W., Tseng, H. L., Deng, Y., Hoi, P. M., Choi, P. S., Or, P. M., Yang, J. M., Lam, F. F., Lee, S. M., Leung, G. P., Kong, S. K., Ho, H. P., Kwan, Y. W. & Yeung, J. H.* Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions. Phytomedicine 19, 1263-1269, doi:10.1016/j.phymed.2012.08.011 (2012).

  13. Hu, G., Mahady, G. B., Li, S., Hoi, M. P., Wang, Y. H. & Lee, S. M.* Polysaccharides from astragali radix restore chemical-induced blood vessel loss in zebrafish. Vasc Cell 4, 2, doi:10.1186/2045-824X-4-2 (2012).

  14. Tang, J. Y., Li, S., Li, Z. H., Zhang, Z. J., Hu, G., Cheang, L. C., Alex, D., Hoi, M. P., Kwan, Y. W., Chan, S. W., Leung, G. P. & Lee, S. M.* Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS One 5, e11822, doi:10.1371/journal.pone.0011822 (2010).

  15. Hoi, P. M., Visintin, C., Okuyama, M., Gardiner, S. M., Kaup, S. S., Bennett, T., Baker, D., Selwood, D. L. & Hiley, C. R.* Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat. Br J Pharmacol 152, 751-764, doi:10.1038/sj.bjp.0707470 (2007).

  Social Service

  • Member, Scientific Review Committee, Macao Regional Science Fair (Education and Youth Affairs Bureau, Macau SAR Government) (Affiliation of Intel International Science and Engineering Fair) (2012-present)
  • Technical Expert (ISO/IEC 17025 Accreditation Assessment), Innovation and Technology Commission (ITC), Hong Kong SAR Government. (2014-present)
  • Reviewer Editor, Frontiers in Cardiovascular and Smooth Muscle Pharmacology. (2014-present)

Contact Details

Institute of Chinese Medical Sciences
University of Macau
Padre Tomás Pereira S.J., Taipa
Macao (SAR), China

Room: 7012, N22
Telephone: (853) 8822-4876
Fax: (853) 28841358
E-mail address
: maghoi@umac.mo