陸金健  助理教授

學歷教學 |學術研究 | 科研論著 | 社會服務 | 聯絡方法



學歷


教學


 學術研究

 

招收博士、碩士研究生及研究助理,歡迎聯繫 jinjianlu@umac.mo


科研論著

著作章節

  1. 中藥抗腫瘤現代研究技術與進展. 人民衛生出版社. ISBN: 978-7-117-16227-2/R·16228. 2012年10月.

期刊文章

已在Free Radical Biology & Medicine, Redox Biology, Biochemical Pharmacology, Oncotarget, Scientific Reports等專業期刊上發表論文100餘篇(h-index=25, google scholar, Mar 17, 2017)。

*通訊作者或共同通訊作者, #共同第一作者

  1. Tang ZH, Cao WX, Wang ZY, Lu JH, Liu B, Chen X, Lu JJ*. Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells. Redox Biology. 2017, 12: 367-76.
  2. Tang ZH, Cao WX, Su MX, Chen X, Lu JJ*. Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells. Toxicology and Applied Pharmacology. 2017, 321: 18-26.
  3. Xu XH, Zhang LL, Wu GS, Chen X, Li T, Chen X*, Wang YT, Lu JJ*. Solasodine induces apoptosis, affects autophagy, and attenuates metastasis in ovarian cancer cells. Planta Medica. 2017, 83(3-4): 254-60.
  4. Wang YF, Xu YL, Tang ZH, Li T, Zhang LL, Chen X, Lu JH, Leung CH, Ma DL, Qiang WA, Wang YT, Lu JJ*. Baicalein induces Beclin 1- and extracellular signal-regulated kinase- dependent autophagy in ovarian cancer cells. The American Journal of Chinese Medicine. 2017, 45(1): 123-36.
  5. Li T, Chen X, Chen XP, Ma DL, Leung CH, Lu JJ*. Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells. Scientific Reports. 2016, In Press.
  6. Tang ZH, Jiang XM, Guo X, Fong CM, Chen XP, Lu JJ*. Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line. Oncotarget. 2016, 7(49): 81598-610.
  7. Tang ZH, Chen X, Wang ZY, Chai K, Wang YF, Xu XH, Wang XW, Lu JH, Wang YT, Chen XP, Lu JJ*. Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Scientific Reports. 2016, 6: 25241.
  8. Zhang LL, Xu YL, Tang ZH, Xu XH, Chen X, Li T, Ding CY, Huang MQ, Chen XP, Wang YT, Yuan XF*, Lu JJ*. Effects of alisol B 23-acetate on ovarian cancer cells: G1 phase cell cycle arrest, apoptosis, migration and invasion inhibition. Phytomedicine. 2016, 23(8): 800-9.
  9. Zhang LL, Tian K, Tang ZH, Chen XJ, Bian ZX, Wang YT*, Lu JJ*. Phytochemistry and pharmacology of Carthamus tinctorius L. The American Journal of Chinese Medicine. 2016, 44(2): 197-226.
  10. Chen X, Wu QS, Meng FC, Tang ZH, Chen XP, Lin LG, Chen P, Qiang WA, Wang YT, Zhang QW*, Lu JJ*. Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells. Phytomedicine. 2016, 23(13): 1555-65.
  11. Xu XH, Li T, Fong CM, Chen XP, Chen XJ, Wang YT, Huang MQ*, Lu JJ*. Saponins from Chinese medicines as anticancer agents. Molecules. 2016, 21: 1326.
  12. Wang YF, Tang ZH, Li T, Xu XH, Chen XP, Wang Y, Wang YT, Lu JJ*. Baicalein protects tert-butyl hydroperoxide-induced hepatotoxicity dependent of reactive oxygen species removal. Molecular Medicine Reports. 2016, In Press.
  13. Bao H, Zhang LL, Liu QY, Feng L, Ye Y, Lu JJ*, Lin LG*. Cytotoxic and pro-apoptotic effects of cassane diterpenoids from the seeds of caesalpinia sappan in cancer cells. Molecules. 2016, 21(6): 791.
  14. Ren GW, Luo WW, Sun W, Niu YN, Ma DL, Leung CH, Wang YT, Lu JJ*, Chen XP*. Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells. Phytomedicine. 2016, 23(9): 939-47.
  15. Wang L, Wang YF, Wang XQ, Sun L, Zhou ZZ, Lu JJ*, Zheng Y*. Encapsulation of low lipophilic and slightly water-soluble dihydroartemisinin in PLGA nanoparticles with phospholipid to enhance encapsulation efficiency and in vitro bioactivity. Journal of Microencapsulation. 2016, 33(1): 43-52.
  16. Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ*. Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Oncotarget. 2015, 6(41): 43911-26.
  17. Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ*. A systematic review of the anticancer properties of compounds isolated from Licorice (Gancao). Planta Medica. 2015, 81: 1670-87.
  18. Li T, Xu XX, Tang ZH, Wang YF, Leung CH, Ma DL, Chen XP, Wang YT, Chen Y, Lu JJ*. Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells. Acta Pharmacologica Sinica. 2015, 36(12): 1503-13.
  19. Li T, Tang ZH, Xu WS, Wu GS, Wang YF, Chang LL, Zhu H, Chen XP, Wang YT, Chen Y, Lu JJ*. Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. European Journal of Pharmacology. 2015, 749: 81-8.
  20. Wang YF, Li T, Tang ZH, Chang LL, Zhu H, Chen XP, Wang YT*, Lu JJ*. Baicalein triggers autophagy and inhibits the protein kinase B/mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells. Phytotherapy Research. 2015, 29, 674-9.
  21. Chen XJ, Tang ZH, Li XW, Xie CX, Lu JJ*, Wang YT*. Chemical constituents, quality control, and bioactivity of Epimedii Folium (Yinyanghuo). The American Journal of Chinese Medicine. 2015, 43(5): 783-834.
  22. Lu JJ*, Lu DZ, Chen YF, Dong YT, Zhang JR, Li T, Tang ZH, Yang Z. Proteomic analysis of HepG2 hepatocellular carcinoma cells treated with platycodin D. Chinese Journal of Natural Medicines. 2015, 13(9): 673-9.
  23. Xu W, Li T, Qiu JF, Wu SS, Huang MQ*, Lin LG, Zhang QW, Chen XP, Lu JJ*. Anti-proliferative activities of terpenoids isolated from Alisma orientalis and their structure-activity relationships. Anti-Cancer Agents in Medicinal Chemistry. 2015, 15(2): 228-35.
  24. Zhang MY, Lu JJ*, Wang L, Gao ZC, Hu H*, Ung OL, Wang YT. Development of monoclonal antibodies in China: Overview and prospects. BioMed Research International. 2015, 2015: Article ID 168935, 10 pages.
  25. Zhu H*, Liao SD, Shi JJ, Chang LL, Tong YG, Cao J, Fu YY, Chen XP, Ying MD, Yang B, He QJ, Lu JJ*. DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal. Free Radical Biology & Medicine. 2014, 71: 121-32.
  26. Tang ZH, Li T, Chang LL, Zhu H, Tong YG, Chen XP, Wang YT, Lu JJ*. Glycyrrhetinic acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. Journal of Agricultural and Food Chemistry. 2014, 62(49): 11910-6.
  27. Tang ZH, Li T, Gao HW, Sun W, Chen XP, Wang YT, Lu JJ*. Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells. Chinese Medicine. 2014, 9: 16.
  28. Li T, Xu WS, Wu GS, Chen XP, Wang YT*, Lu JJ*. Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells. Asian Pacific Journal of Cancer Prevention. 2014, 15(4): 1745-9.
  29. Xu WS, Li T, Wu GS, Dang YY, Hao WH, Chen XP, Lu JJ*, Wang YT*. Effects of furanodiene on 95-D lung cancer cells: apoptosis, autophagy and G1 phase cell cycle arrest. The American Journal of Chinese Medicine. 2014, 42(1): 243-55.
  30. Xu WS, Dang YY, Chen XP, Lu JJ*, Wang YT*. Furanodiene presents synergistic anti-proliferative activity with paclitaxel via altering cell cycle and integrin signaling in 95-D lung cancer cells. Phytotherapy Research. 2014, 28(2): 296-9.
  31. Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ*, Wang YT*. Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. PLoS ONE. 2013, 8(10): e76620.
  32. Wu GS, Guo JJ, Bao JL, Li XW, Chen XP, Lu JJ*, Wang YT*. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum—A review. Expert Opinion on Investigational Drugs. 2013, 22(8): 981-92.
  33. Wu GS, Lu JJ*, Guo JJ, Huang MQ, Gan L, Chen XP, Wang YT*. Synergistic anti-cancer activity by the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Pharmacological Reports. 2013, 65 (2): 453-9.
  34. Lu JJ, Bao JL, Wu GS, Xu WS, Huang MQ, Chen XP*, Wang YT*. Quinones derived from plant secondary metabolites as anti-cancer agents. Anti-Cancer Agents in Medicinal Chemistry. 2013, 13(3): 456-63
  35. Xu WS, Dang YY, Guo JJ, Wu GS, Lu JJ*, Chen XP, Wang YT*. Furanodiene induces endoplasmic reticulum stress and presents anti-proliferative activities in lung cancer cells.  Evidence-Based Complementary and Alternative Medicine. 2012, 2012: Article ID 426521, 8 pages.
  36. Wu GS, Lu JJ*, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT*. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012, 83(2): 408-14.
  37. Lu JJ*, Bao JL, Chen XP, Huang M, Wang YT*. Alkaloids isolated from natural herbs as the anti-cancer agents. Evidence-Based Complementary and Alternative Medicine. 2012, 2012: Article ID 485042, 12 pages.
  38. Lu JJ*, Yang Z, Lu DZ, Wo, XD, Shi JJ, Lin TQ, Wang MM, Li Y, Tang LH. Dihydroartemisinin-induced inhibition of proliferation in BEL-7402 cells: An analysis of the mitochondrial proteome. Molecular Medicine Reports. 2012, 6(2): 429-33.
  39. Lu JJ, Pan W, Hu YJ*, Wang YT*. Multi-target drugs: The trend of drug research and development. PLoS ONE. 2012, 7(6): e40262.
  40. Lu JJ, Chen SM, Ding J*, Meng LH*. Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line. Molecular and Cellular Biochemistry. 2012, 360(1-2): 329-37.
  41. Lu JJ, Dang YY, Huang M, Xu WS, Chen XP*, Wang YT*. The anti-cancer properties of terpenoids from Rhizoma Curcumae—A review. Journal of Ethnopharmacology. 2012, 143(2): 406-11.
  42. Lu JJ, Cai YJ*, Ding J*. The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells. Molecular and Cellular Biochemistry. 2012, 360(1-2): 253-60.
  43. Huang M, Lu JJ#, Huang MQ, Chen XP, Wang YT*. Terpenoids: natural products for cancer therapy. Expert Opinion on Investigational Drugs. 2012, 21(12): 1801-18.
  44. Tan W, Lu JJ#, Huang MQ, Li YB, Chen MW, Wu GS, Gong J, Zhong ZF, Xu ZT, Dang YY, Guo JJ, Chen XP*, Wang YT*. Anti-cancer natural products isolated from Chinese medicinal herbs. Chinese Medicine. 2011, 6: 27.
  45. Lu JJ, Cai YJ*, Ding J*. Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells. Molecular and Cellular Biochemistry. 2011, 354(1-2): 247-52.
  46. Lu JJ, Chen SM, Zhang XW, Ding J*, Meng LH*. The anticancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells. Investigational New Drugs. 2011, 29(6): 1276-83.
  47. Lu JJ, Meng LH*, Shankavaram UT, Zhu CH, Tong LJ, Chen G, Lin LP, Weinstein JN, Ding J*. Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells. Biochemical Pharmacology. 2010, 80(1):22-30.
  48. Lu JJ, Meng LH*, Cai YJ, Chen Q, Tong LJ, Lin LP, Ding J*. Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species. Cancer Biology & Therapy. 2008, 7(7):1017-23.

 

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