jbwan

Jianbo Wan  萬建波
Associate Professor

Academic Qualifications | Teaching | Research | Selected Publications | Contact Details


Academic Qualifications

 

l   MSc, PhD, University of Macau

l   MSc, China Pharmaceutical University

l   BSc, Wuhan University

 


Teaching


Research

Research Interests

      Metabonomic study on Chinese Medicines and metabolic diseases,

      Pharmacological study on Chinese Medicines for the prevention of metabolic diseases, including fatty liver and atherosclerosis.


Selected Publications

[1].                 Zhang XJ, Huang LL, Su H, Chen YX, Huang J, He C, Li P, Yang DZ, Wan JB*, Characterizing plasma phospholipid fatty acid profiles of polycystic ovary syndrome patients with and without insulin resistance using GC-MS and chemometrics approach. J Pharm Biomed Anal. 2014, 95C:85-92

[2].                 Zhang XJ, Su H, He CW, Wang YT, Yang FQ, Wan JB*. Discrimination of Pterocephalus hookeri collected at flowering and non-flowering stages using GC-MS-based fatty acid profiling. Anal. Methods, 2014,6, 2141-2149

[3].                 Zhang XJ, Qiu JF, Guo LP, Wang Y, Li P, Yang FQ, Su H, Wan JB*. Discrimination of multi-origin Chinese herbal medicines using gas chromatography-mass spectrometry-based Fatty Acid profiling. Molecules. 2013 Dec 11;18(12):15329-43

[4].                 Wan JB*, Bai X, Cai XJ, Rao Y; Wang, YS, Wang YT. Chemical differentiation of Da-Cheng-Qi-Tang, a Chinese medicine formula, prepared by traditional and modern decoction methods using UPLC/Q-TOFMS-based metabolomics approach. J Pharm Biomed Anal, 2013, 83C:34-42

[5].                 Huang LL, Wan JB*, Wang B, He CW, Ma H, Li TW, Kang JX*. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. Prostaglandins Leukot Essent Fatty Acids. 2013; 88(5):347-53

[6].                 Zhang XJ, Huang LL, Cai XJ, Li P, Wang YT, Wan JB*. Fatty acid variability in three medicinal herbs of Panax species. Chem Cent J. 2013 Jan 21;7(1):12.

[7].                 Ding RB, Tian K, He CW, Jiang Y, Wang YT, Wan JB*. Herbal medicines for the prevention of alcoholic liver diseases: a review. J Ethnopharmacol. 2012, 144(3):457-65.

[8].                 Wan JB, Li P, Yang RL, Zhang QW, Wang YT. Separation and purification of 5 saponins from Panax notoginseng by preparative high-performance liquid chromatography. J Liq Chromatogr RT. 2013, 36:406–417.

[9].                 Wan JB, Zhang QW, Hong SJ, Li P, Li SP, Wang YT. Chemical investigation of saponins in different parts of Panax notoginseng by pressurized liquid extraction and liquid chromatography-electrospray ionization- tandem mass spectrometry. Molecules. 2012,17(5):5836-53

[10].             Wan JB, LL Huang, Rong R, Tan R, J Wang, JX Kang. Endogenously Decreasing Tissue n-6/n-3 Fatty Acid Ratio Reduces Atherosclerotic Lesions in Apolipoprotein E-Deficient Mice by Inhibiting Systemic and Vascular Inflammation. Arterioscler. Thromb. Vasc. Biol. 2010, 30: 2487-2494.

Comment in: Deckelbaum RJ. n-6 and n-3 Fatty Acids and Atherosclerosis: Ratios or Amounts? Arterioscler Thromb Vasc Biol. 2010; 30: 2325-2326.

[11].             Wan JB, Lee SM, Wang JD, Wang N, He CW, Wang YT, Kang JX. Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. J. Agric. Food. Chem. 2009, 57: 6692-6697.

[12].             Wan JB, QW Zhang, SJ Hong, J Guan, WC Ye, SP Li, MY Lee, YT Wang. 5,6-Didehydrogin senosides from the Roots of Panax notoginseng. Molecules. 2010, 15: 8169-8176.

[13].             Wan JB, QW Zhang, WC Ye, YT Wang, Quantification and separation of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins. Sep. Pur. Tech. 2008, 60: 198-205.

[14].             Wan JB, YT Wang, JM Chen, SP Li. Chemical characteristics for three medicinal plants from Panax genus using pressurized liquid extraction and HPLC-ELSD. J. Sep. Sci. 2007, 30: 825-832.

[15].             Wan JB, CM Lai, SP Li, MY Lee, LY Kong, YT Wang. Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction. J Pharm Biomed Anal. 2006, 41: 274-279.

[16].             Wan JB, SP Li, YT Wang. Chemical characteristics of different parts from Panax notoginseng by HPLC-ELSD. J Pharm Biomed Anal. 2006, 41: 1596-1601.

[17].             Wan JB, P Li, SP Li, YT Wang, TX Dong, Karl WK Tsim. Simultaneous determination of 11 saponins in Panax notoginseng using HPLC-ELSD and pressurized liquid extraction. J. Sep. Sci. 2006, 29: 2190-2196.

[18].             Wan JB, C Xu, SP Li, LY Kong, YT Wang. Studies on the pressurized solvent extraction of isoflavonoids from Pueraria Lobata. Chin. Anal. Chem. 2005, 33: 1435~1438.

[19].             Wan JB, SP Li, JR Jian, LY Kong, YT Wang. Analysis of Saponins from Panax notoginseng Using Pressurized Solvent Extraction Coupled with High Performance Thin Layer Chromatography. Chin J Nat Med. 2004, 2: 215-218

 

[20].              Ni N, Hu Y, Ren H, Luo C, Li P, Wan JB, Su H. Self-Assembling Peptide Nanofiber Scaffolds Enhance Dopaminergic Differentiation of Mouse Pluripotent Stem Cells in 3-Dimensional Culture. PLoS ONE, 2013,8(12): e84504.

[21].             Zhu HL, Wan JB, Wang YT, Li BC, Xiang C, He J, Li P. Medicinal compounds with antiepileptic/anticonvulsant activities. Epilepsia. 2013

[22].             Kang JX, Wan JB, He CW. Regulation of stem cell proliferation and differentiation by essential fatty acids and their metabolites, Stem Cell, accepted.

[23].             Wu JH, Leung GP, Kwan YW, Sham TT, Tang JY, Wang YH, Wan JB, Lee MY, Cha SW. Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats. Journal of Functional Foods, 2013, 5(3): 1159-1169

[24].             Yao XL, Ye CH, Liu Q, Wan JB, Zhen J, Xiang AP, Li WQ, Wang Y, Su H, Lu X. Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice. Plos One, 2013, e64720.

[25].             Su H, Wang L, Cai J, Yuan Q, Yang X, Yao X, Wong WM, Huang W, Li Z, Wan JB, Wang Y, Pei D, So KF, Qin D, Wu W. Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle. Stem Cell Res. 2013 Mar 5, 11(1):529-539.

[26].             Li F, Zhang LD, Li BC, Yang J, Yu H, Wan JB, Wang YT, Li P. Screening of free radical scavengers from Erigeron breviscapus using on-line HPLC-ABTS/DPPH based assay and mass spectrometer detection. Free Radic Res. 2012, 46(3):286-94

[27].             He C, Rong R, Liu J, Wan JB, Zhou K, Kang JX. Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells. Chin Med. 2012 Apr 30;7(1):11

[28].             He C, Qu X, Wan JB, Rong R, Huang L, Cai C, Zhou K, Gu Y, Qian SY, Kang JX. Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice. Plos One, 2012, 7, e47567.

[29].             Wang S, Zhong Z, Wan JB, Tan W, Wu G, Chen M, Wang Y. Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am J Chin Med. 2013;41(1):177-96.

[30].             Wang N, Wan JB, Chan SW, Deng YH, Yu N, Zhang QW, Wang YT, Lee SM. Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion. Chin Med. 2011 Oct 13;6(1):37

[31].             Shen LR, Lai CQ, Feng X, Parnell LD, Wan JB, Wang JD, Li D, Ordovas JM, Kang JX. Drosophila lacks C20 and C22 PUFAs. J Lipid Res. 2010, 51: 2985-2992.

[32].             Hong SJ, Wan JB, Zhang Y, Hu G, Lin HC, Seto SW, Kwan YW, Lin ZX, Wang YT, Lee SM. Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo. Phytother Res. 2009, 23: 677-686

[33].             Qian ZM, Wan JB, Zhang QW, Li SP. Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography. J. Pharm. Biomed. Anal. 2008, 48: 1361-1367.

[34].             CM Lai, SP Li, H Yu, Wan JB, KW Kan, YT Wang. A rapid HPLC–ESI- MS/MS for qualitative and quantitative analysis of saponins in “XUESETONG” injection. J Pharm Biomed Anal. 2006, 40: 669-678.

[35].             SC Lao, SP Li, Kelvin KW Kan, P Li, Wan JB, YT Wang, Tina T.X. Dong and Karl W.K. Tsim. Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction. Analytica Chimica Acta. 2004, 526: 131-137.

 

[36].             Wan JB, SP Li, YT Wang. Chemical characteristics of Panax notoginseng using RP-HPLC. Acta Pharm Sin.(藥學學報) 2006, 41: 1090-1093 .

[37].             Wan JB, CM Li, SP Li, LY Kong, YT Wang. Analysis of Saponins from Panax notoginseng using Pressurized Solvent Extraction Coupled with Liquid Chromatography-Electrospray Mass Spectrum. J. Chin. Med. Mater. (中藥材) 2005, 28: 885~890

[38].             Wan JB, SP Li, JR Jian, LY Kong, YT Wang. Advances in Quality Evaluation of Piper methysticum. Progress In Pharmaceutical Sciences (藥學進展). 2005,29: 19-22

[39].             X Li, Wan JB, MY Lee, YT Wang. Progress in the pharmaceutical study of Radix puerariae. Chin J New Drugs (新藥雜誌) 2010, 19: 662-665

[40].             SJ Hong, Wan JB, QW Zhang, Y Zhang, G Hu, CQ Liu, MY Lee, YT Wang. Proangiogenic effect of total saponins of Panax notoginseng in human umbilical vein endothelial cell (HUVEC). Pharmacol. Clin. Chin. Mater. Medica (中藥理與臨床) 2007, 23: 28-30.

[41].             N Wang, Wan JB, MY Lee, YT Wang. A review on atheroprotective effect of Panax notoginseseng. Chin. Tradit. Herb. Drugs (中草藥), 2008, 39: 787-790.

[42].             P Li, Wan JB, SP Li, YT Wang, Studies on the Accelerated Solvent Extraction of Panax notoginseng saponins, Chinese Journal of Natural Medicines (天然藥物). 2004,2:157-161.

[43].             JC Song, SD Luo, Wan JB, QE Yu, Study on pharmacokinetics of ferul ic acid in Shenghua Tang in rabbits, Chin. Pharm. J. (中國藥學雜誌)2003,38(1): 49-51

 

Book & Chapter

 

[1].       Wan JB, Wang YT, Li SP. Panax notoginseng (Sanqi 三七). In Chinese herbs: Pharmacological Activities and Quality Control. Shaoping Li, Ed. Nova Science Publishers, Inc.: New York, 2008: 179-203. (ISBN: 978-1-60456-823-3)

[2].       Wan JB, Chen Y, Li Ping, Huang WH, Zhang QW. Saponins from Panax Species: Chemistry, Isolation and Analysis. In:  Saponins: Properties, Applications and Health Benefits. Rani Koh and Isaac Tay ed., Nova Science Publishers, Inc. New York, 2012: 51-98. (ISBN: 978-1-62100-942-9)

[3].       Zhang XJ, Su HX, Wan JB*, Wang YT. Therapeutic Potential of Ginsenosides in Management of Atherosclerosis. In: Phytotherapies: Efficacy, Safety and Regulation. Iqbal Ramzan ed., Wiley, Inc. 2014 (Submitted) 

 

Patent


 

Contact Details

 

Institute of Chinese Medical Sciences

University of Macau

Macao, China

 

Room: 6034, N22

Telephone: (853) 8822-4680

Fax: (853) 28841358

E-mail: jbwan@umac.mo