Ging CHAN

Associate Professor, Institute of Chinese Medical Sciences

 

Academic Qualifications:

Ph.D., University of Illinois, Urbana-Champaign, IL USA

Post Doc.  Eli Lilly & Company

Post Doc.  University of Chicago

 

Teaching:

Quantitative Reasoning for Business

 

Research Interests:

Bioinformatics,

Big data in traditional Chinese medicine

Development of health food

 

Patents

Chan, G., Heiman, M. and Hsiung, H. Precursor Forms of Porcine Growth Hormone-Releasing Factor and related DNA Compounds (1991). Patent number: EP 459747, CA 2043049, ZA 9103876, JP 05068559, AU 9178003, AU 639107, HU 58799

Bierman, K., Chan, G., Heiman, M., and Hsiung, H. Precursor Forms of Bovine Growth Hormone-Releasing Factor and Related DNA Compounds (1992). Patent Number: EP19920303465 19920416

 

Publications

1.      Nelson B. Phillips, Agnes Jancso-Radek, Varda Ittah, Rupinder Singh, Ging Chan, Elisha Haas and Michael A. Weiss (2006). SRY and Human Sex Determination: The Basic Tail of the HMG Box Functions as a Kinetic Clamp to Augment DNA Bending. J. Mol. Biol. (2006) 358, 172–192

2.      Biaoru Li, Wei Zhang, Ging Chan, Agnes Jancso-Radek, Shunhe Liu and Michael A. Weiss (2001). MOLECULAR BASIS OF CELL AND DEVELOPMENTAL BIOLOGY: Human Sex Reversal Due to Impaired Nuclear Localization of SRY: A CLINICAL CORRELATION. J. Biol. Chem. 276:46480-46484.

3.      Etsuji Ukiyama, Agnes Jancso-Radek†, Biaoru Li, Lukasz Milos, Wei Zhang, Nelson B. Phillips, Nobuyuki Morikawa, Chih-Yen King, Ging Chan, Christopher M. Haqq, James T. Radek, Francis Poulat, Patricia K. Donahoe, and Michael A. Weiss (2001). SRY and Architectural Gene Regulation: The Kinetic Stability of a Bent Protein-DNA Complex Can Regulate Its Transcriptional Potency. Molecular Endocrinology 15(3): 363–377

4.      Benevides, J. M., Chan, G., Lu, X.-J., Olson, W. K., Weiss, M. A., & Thomas, J. G. J. (2000). Protein-Directed DNA Structure. I. Raman Spectroscopy of a High-Mobility-Group Box with Application to Human Sex Reversal. Biochemistry, 39, 3, 537.

5.      Leila Su, James T. Radek, Klaas Hallenga, Patrick Hermanto, Ging Chan, Laura A. Labeots, and, and Michael A. Weiss (1997) RNA Recognition by a Bent α-Helix Regulates Transcriptional Antitermination in Phage λ. Biochemistry 36 (42), 12722-12732

6.      Richardson, T.H., Hsu, M-H., Kronbach, T., Barnes, H.J., Chan, G., Waterman, M.R., Kemper, B., and Johnson, E.F. (1993). Purification and Characterization of Recombinant-Expressed Cytochrome P450 2C3 from Escherichia coli: 2C3 Encodes the 6ß-Hydroxylase Deficient Form of P450 3b. Archives of Biochemistry and Biophysics. 300: (1). 510-516.

7.      Chan, G. and Kemper, B. (1990). Structure of the rabbit cytochrome P450IIC3 gene, a constitutive member of the P450IIC subfamily. Biochem. 29: (15). 3743-3750.

8.      Zhao, Z., Chan, G., Govind, G., Bell, P., and Kemper, B. (1990). Structure of 5' regions and expression of phenobarbital-inducible rabbit cytochrome P450IIC genes. DNA and Cell Biology. 9: (1). 37-48.

9.      Chan, G. and Kemper, B. (1988). Structure of the rabbit cytochrome P450IIC3 gene. J. Cell Biol. 6: 195a (Abst. 1114).

10.   Kemper, B., Bell, P., Chan, G., Govind, S., and Zhao, J. (1987). Structure of rabbit cytochrome P-450IIC genes and regulation by phenobarbital. In Microsomes and Drug Oxidations. Proc. 7th Internat. Symp., ed by J. Miners, D.J. Birkett, R. Drew, and M. McManus, pp. 63-70, Taylor and Francis, London.

11.   Govind, S., Bell, P., Zhao, J., Chan, G., and Kemper, B. (1986). Intron locations in the phenobarbital inducible family are conserved. FEBS Advanced Course, Greece. (Abst.)

12.   Govind, S., Bell, P., Zhao, J., Chan, G., and Kemper, B. (1986). Structure of genes in the cytochrome P450PBC subfamily. FEB. Proc. 45: 1855, (Abst. 2155)

13.   Kemper, B., Leighton, J., Govind, S., Bell, P., Chan, G. and Zhao, J. (1985). Structure and expression of a subfamily of the phenobarbital-inducible cytochrome P450 gene family. Fourth International Symposium on Comparative Biochhemistry CYT. P450, Janssen Pharmaceutica, B-2340 Beerse, Belgium. P35. (Abst.)

14.   Kagan, J., Tadema, J., Wielandt, K., Chan, G., Dhawan, S-N., and Jaworsky, J. (1984). Oxygen requirement for near UV mediated cytotoxicity of phenyl heptatriyne to Escherichia-coli. Photochem. photobiol. 39: (4). 465-468.

15.   Kagan, J., Chan, G., Dhawan, S-N., Arora, S-k., and Prakash, I.(1983). The effect of UV light on the toxicity of natural products toward the eggs of Drosophila-Melanogaster. J. Nat. Prod. (Lloydia). 46: (5). 646-650.

16.   Kagan, J., Beny, J-P., Chan, G., Dhawan, S-N., Jaworski, J. A., and Kagan, E-D. (1983). The phototoxicity of some 1, 3 Butadienes and related thiophenes against larvae of the mosquito aedes-aegypti and the fruit fly Drosophila-Melanogaster. Insect Sci Appl. 4: (4). (Recd. 1984). 377-382.

17.   Kagan, J., and Chan, G. (1983). The photo ovicidal activity of plant components toward Drosophila-Melanogaster. Experimentia (Basel). 39: (4). 402-403.

 

Contacts

Institute of Chinese Medical Sciences

SKL of Quality Research in Chinese Medicine

University of Macau, N22-8035

Avenida da Universidade, Taipa, Macau
Email: gchan@umac.mo
Tel: +853-8822-4627