梁重

教授

學歷 | 主講科目 | 學術研究 | 科研論著 | 專業認證 | 聯絡方法


學歷

 

 


主講科目

本科生科目

  1. From Cells to Organisms
  2. Biochemistry and Molecular Biology I
  3. Biochemistry and Molecular Biology II
  4. Biochemistry and Molecular Biology II – Laboratory
  5. Wonders in Life Science and Health: Biomedical Science
  6. Final Year Projects

 

研究生科目

  1. University Teaching I
  2. Drug Targets and Drug Discovery

 


學術研究

研究方向

1. 藥物發現

2. 發光檢測方法

研究組主頁

我們目前正在進行一些關於藥物研發以及生物分子探測的研究項目,歡迎有興趣參與研究的研究生與梁博士聯繫 duncanleung@umac.mo

 


代表性學術論文

1.      Liu LJ, Wang WH, Huang SY, Hong YJ, Li GD, Lin S, Tian JL, Cai ZW,* Wang HMD,* Ma DL,* Leung CH (Corresponding author).* (2017) Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(III) metal-based compound. Chem Sci 8, 4756.
Inside back cover
Impact factor: 8.668

2.      Ko CN, Yang C, Lin S, Li SN, Dong ZZ, Liu JB,* Lee SMY,* Leung CH (Corresponding author),* Ma DL.* (2017) A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation. Biosens Bioelectron 94, 575.
Impact factor: 7.78

3.      Kang TS, Wang WH, Zhong HJ, Dong ZZ, Huang Q, Mok SWF, Leung CH (Corresponding author),* Wong VKW,* Ma DL.* (2017) An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB. Cancer Lett 396, 76.
Impact factor: 6.375

4.      Dong ZZ, Lu LH, Wang WH, Li GD, Kang TS, Han QB, Leung CH (Corresponding author),* Ma DL.* (2017) Luminescent detection of nicking endonuclease Nb.BsmI activity by using a G-quadruplex-selective iridium(III) complex in aqueous solution. Sensor Actuat B-Chem 246, 826.
Impact factor: 5.401

5.      Yang C, Wang WH, Liang JX, Li GD, Vellaisamy K, Wong CY, Ma DL,* Leung CH (Corresponding author).* (2017) A rhodium(III)-based inhibitor of lysine-specific histone demethylase 1 as an epigenetic modulator in prostate cancer cells. J Med Chem 60, 2597.
Impact factor: 6.259

6.      Wang WH, Yang C, Lin S, Vellaisamy K, Li GD, Tan WH,* Leung CH (Corresponding author),* Ma DL.* (2017) First synthesis of an oridonin-conjugated iridium(III) complex for the intracellular tracking of NF-κB in living cells. Chem Eur J 23, 4929.
Impact factor: 5.137

7.      Liu CF, Yang C, Lu L, Wang WH, Tan WH,* Leung CH (Corresponding author),* Ma DL.* (2017) Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells. Chem Commun 53, 2822.
Back cover
Impact factor: 6.319

8.      Dong ZZ, Lu L, Ko CN, Yang C, Li S, Lee MY, Leung CH (Corresponding author),* Ma DL.* (2017) A MnO2 nanosheet-assisted GSH detection platform by using iridium(III) complex as a switch-on luminescent probe. Nanoscale 9, 4631.
Inside front cover
Impact factor: 7.367

9.      Zhong HJ,* Wang WH, Kang TS, Yan H, Yang YL, Xu LP, Wang YQ, Ma DL,* Leung CH (Corresponding author).* (2016) A rhodium(III) complex as an inhibitor of neural precursor cell expressed, developmentally down-regulated 8-activating enzyme with in vivo activity against inflammatory bowel disease. J Med Chem 60, 497.
Impact factor: 6.259

10.  Ma DL,* Lin S, Wang WH, Yang C, Leung CH (Corresponding author).* (2017) Luminescent chemosensors by using cyclometalated iridium(III) complexes and their applications. Chem Sci 8, 878.
Impact factor: 8.668

11.  Lin S, Lu L, Kang TS, Mergny JL, Leung CH (Corresponding author),* Ma DL.* (2016) The interaction of an iridium(III) complex with G-quadruplex DNA and its application in luminescent switch-on detection of Siglec-5. Anal Chem 88, 10290.
Impact factor: 6.32

12.  Yang C, Wang WH, Chen LM, Liang JX, Lin S, Lee SMY, Ma DL,* Leung CH (Corresponding author).* (2016) Discovery of a VHL and HIF1α interaction inhibitor with in vivo angiogenic activity by structure-based virtual screening. Chem Commun 52, 12837.
Impact factor: 6.319

13.  Liu LJ, Wang WH, Zhong Z, Lin S, Lu L, Wang YT, Ma DL,* Leung CH (Corresponding author).* (2016) Inhibition of TLR1/2 dimerization by enantiomers of metal complexes. Chem Commun 52, 12278.
Front cover
Impact factor: 6.319

14.  Lin S, Kang TS, Lu L, Wang WH, Ma DL,* Leung CH (Corresponding author).* (2016) A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity. Biosens Bioelectron 86, 849.
Impact factor: 7.78

15.  Ma DL,* Wang M, Liu CF, Miao XM, Kang TS, Leung CH (Corresponding author).* (2016) Metal complexes for the detection of disease-related protein biomarkers. Coord Chem Rev 324, 90.
Impact factor: 13.324

16.  Miao XM, Wang WH, Kang TS, Liu JB, Shiu KK, Leung CH, Ma DL.* (2016) Ultrasensitive electrochemical detection of miRNA-21 by using an iridium(III) complex as catalyst. Biosens Bioelectron 86, 454.
Impact factor: 7.78

17.  Lu L,* Mao ZF, Kang TS, Leung CH (Corresponding author),* Ma DL.* (2016) A versatile nanomachine for the sensitive detection of platelet-derived growth factor-BB utilizing a G-quadruplex-selective iridium(III) complex. Biosens Bioelectron 85, 300.
Impact factor: 7.78

18.  Leung CH (Corresponding author),* Liu LJ, Leung KH, Ma DL.* (2016) Epigenetic modulation by inorganic metal complexes. Coord Chem Rev 319, 25.
Impact factor: 13.324

19.  Kang TS, Mao ZF, Ng CT, Wang M, Wang WH, Wang CM, Lee SMY, Wang YT, Leung CH (Corresponding author),* Ma DL.* (2016) Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α. J Med Chem 59, 4026.
Impact factor: 6.259

20.  Zhong HJ, Lee BR, Boyle JW, Wang WH, Ma DL,* Chan PWH,* Leung CH (Corresponding author).* (2016) Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction. Chem Commun 52, 5788.
Front cover
Impact factor: 6.319

21.  Liu LJ, He BY, Miles JA, Wang WH, Mao ZF, Che WI, Lu JJ, Chen XP, Wilson AJ, Ma DL,* Leung CH (Corresponding author).* (2016) Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium (III) compounds. Oncotarget 7, 13965.
Impact factor: 5.168

22.  Zhong HJ, Lu L, Wong CL-C , Peng C, Yan SC, Ma DL,* Cai ZW,* Wang HMD* and Leung CH (Corresponding author).* (2015) An iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent. Chem Sci 6, 5400.
Impact factor: 8.668

23.  Liu LJ, Lu L, Zhong HJ, He BY, Kwong D, Ma DL,* Leung CH (Corresponding author).* (2015) An Iridium() complex inhibits JMJD2 activities and acts as a potential epigenetic modulator. J Med Chem 16, 6697.
Impact factor: 6.259

24.  Wang WH, Mao ZF, Wang M, Liu LJ, Kwong DWJ, Leung CH (Corresponding author),* Ma DL.* (2016) A long lifetime luminescent iridium(III) complex chemosensor for selective switch-on detection of Al3+ ions. Chem Commun 52, 3611.
Front cover
Impact factor: 6.319

25.  Lin S, Yang C, Mao Z, He BY, Wang YT, Leung CH (Corresponding author),* Ma DL.* (2016) A G-pentaplex-based assay for Cs+ ions in aqueous solution using a luminescent Ir(III) complex. Biosens Bioelectron 77, 609.
Impact factor: 7.78

26.  Leung KH, He BY, Yang C, Leung CH (Corresponding author),* Wang HM,* Ma DL.* (2015) Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation. ACS Appl Mater Interfaces 7, 24046.
Impact factor: 7.504

27.  Lin S, He B, Yang C, Leung CH (Corresponding author),* Mergny JL,* Ma DL.* (2015) Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium(III) complex. Chem Commun 51, 16033.
Front cover
Impact factor: 6.319

28.  Zhong Z, Liu LJ, Dong ZQ, Lu L, Wang M, Leung CH (Corresponding author),* Ma DL,* Wang YT.* (2015) Structure-based discovery of an immunomodulatory inhibitor of TLR1-TLR2 heterodimerization from a natural product-like database. Chem Commun 51, 11178.
Impact factor: 6.319

29.  Lu L, Wang M, Liu LJ, Wong CY, Leung CH (Corresponding author),* Ma DL.* (2015) A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe. Chem Commun 49, 9953.
Impact factor: 6.319

30.  Leung CH (Corresponding author),* Liu LJ, Lu L, He B, Kwong DWJ, Wong CY,* Ma DL.* (2015) A metal-based tumour necrosis factor-alpha converting enzyme inhibitor. Chem Commun 51, 3973.
Front cover
Impact factor: 6.319

31.  Leung KH, He HZ, Zhong HJ, Lin S, Wang YT, Ma DL,* Leung CH (Corresponding author).* (2015) Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe. Chem Sci 6, 2166.
Front cover
Impact factor: 8.668

32.  Ma DL,* Chan DSH, Leung CH (Corresponding author).* (2014) Group 9 organometallic compounds for therapeutic and bioanalytical applications. Acc Chem Res 47, 3614.
Impact factor: 20.268

33.  Lu L, Chan DSH, Kwong DWJ, He HZ,* Leung CH (Corresponding author),* Ma DL.* (2014) Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe. Chem Sci 5, 4561.
Inside front cover
Impact factor: 8.668

34.  Ma DL,* Chan DSH, Wei G, Zhong HJ, Yang H, Leung LT, Gullen EA, Chiu P,* Cheng YC,* Leung CH (Corresponding author).*  (2014) Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library. Chem Commun 50, 13885.
Inside front cover
Impact factor: 6.319

35.  Ma DL,* Liu LJ, Leung KH, Chen YT, Zhong HJ, Chan DSH, Wang HMD,* Leung CH (Corresponding author).* (2014) Antagonising STAT3 dimerization with a rhodium(III) complex. Angew Chem Int Ed 53, 9178.
Back cover
Selected as very important paper
Highlighted by SciBX, Nature Publishing Group, 2014, 7(26)

Impact factor: 11.994

36.  Liu LJ, Leung KH, Chan DSH, Wang YT, Ma DL,* Leung CH (Corresponding author).* (2014) Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell Death Dis 5, e1293.
Impact factor: 5.965

37.  He HZ, Leung KH, Wang W, Chan DSH, Leung CH, Ma DL.* (2014) Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe. Chem Commun 50, 5313.
Inside front cover
Impact factor: 6.319

38.  Leung CH (Corresponding author),* He HZ, Liu LJ, Wang M, Chan DSH, Ma DL.* (2013) Metal complexes as inhibitors of transcription factor activity. Coord Chem Rev 257, 3139.
Impact factor: 13.324

39.  Leung CH (Corresponding author),* Zhong HJ, Chan DSH, Ma DL.* (2013) Bioactive iridium and rhodium complexes as therapeutic agents. Coord Chem Rev 257, 1764.
Impact factor: 13.324

40.  Leung KH, He HZ, Ma VPY, Zhong HJ, Chan DSH, Zhou J, Mergny JL, Leung CH (Corresponding author),* Ma DL.* (2013) Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe. Chem Commun 49, 5630.
Front cover
Impact factor: 6.319

41.  Ma DL,* Chan DSH, Leung CH (Corresponding author).* (2013) Drug repositioning by structure-based virtual screening. Chem Soc Rev 42, 2130.
Impact factor: 38.618

42.  Leung CH (Corresponding author),* Zhong HJ, Yang H, Cheng Z, Chan DSH, Ma VPY, Abagyan R, Wong CY, Ma DL.* (2012) A metal-based inhibitor of tumor-necrosis factor-alpha. Angew Chem Int Ed 51, 9010.
Frontispiece
Impact factor: 11.994

43.  Ma DL,* Xu T, Chan DSH, Man BYW, Fong WF, Leung CH (Corresponding author).* (2011) A Highly Selective, Label-Free, Homogenous Luminescent Switch-On Probe for the Detection of Nanomolar Transcription Factor NF-kappaB. Nucleic Acids Res 39, e67.
Impact factor: 10.162

44.  Leung CH (Corresponding author),* Chan DSH, Man BYW, Wang CJ, Lam W, Cheng YC, Fong WF, Hsiao WLW, Ma DL.* (2011) Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3’-5’exonuclease activity. Anal Chem 83, 463.
Front cover
Impact factor: 6.32

45.  Chan DSH, Lee HM, Yang F, Che CM, Wong CCL, Abagyan R, Leung CH (Corresponding author),* Ma DL.* (2010) Structure-Based Discovery of Natural Product-Like TNF-alpha Inhibitors. Angew Chem Int Ed 49, 2860.
Frontispiece
A hot paper chosen by the Editors for its importance in a rapidly evolving field of high current interest
Highlighted by SciBX, Nature Publishing Group, 2010, 3(13)
Impact factor: 11.994

全部著作


專業認證

l   Ad hoc manuscript reviewers, BBA – General subjects, J Med Chem, ChemComm, Anal Chem, PLoS One, Polyhedron, Chembiochem, Nuclei Acids Res., Scientific Reports, etc.

l   Grant reviewer, Blanc – Accords bilatéraux 2013 - SIMI 7 2013 program of the French National Research Agency

l   Guest Editor, Methods Special Issues 

l   Guest Editor, Current Alzheimer Research

l   Editorial Board Member, Scientific Reports, Nature Publishing Group

l   Editorial Board Member, Journal of Analytical & Molecular Techniques

l   Editorial Board Member, Austin Food Sciences           

l   Associate Member, American Association for Cancer Research

l   Panelist, The 11th Meeting of Consortium for Globalization of Chinese Medicine

l   Member, The Consortium for Globalization of Chinese Medicine

l   Member, International Society of Chinese Medicine 

 


聯絡方法

澳門大學中華醫藥研究
氹仔學大馬路
中國澳門
科研大樓N22, 7037
電話 : (853) 8822-4688
傳真 : (853) 2884-1358
電郵: duncanleung@umac.mo

個人網頁: http://duncanleung.weebly.com/