Ying ZHENG  鄭穎

Associate Professor


 

Academic Qualifications | Teaching | Research | Selected Publications | Contact Details


Academic Qualifications

  • B.Sc., Peking University
  • M.Phil., The Chinese University of Hong Kong
  • Ph.D., The Chinese University of Hong Kong

Teaching

Ph.D. Course

  1. Pharmaceutical Engineering and Biomaterials Science  

M.Sc. Courses

  1. Pharmaceutical technology

Research

Research Interests

  • Formulation study on poorly-water soluble APIs (BCS II & IV) in Chinese Medicine, e.g. nanoemulsions, nanocrystals, solid dispersion produced by spray-freeze drying;   
  • Crystal engineering on APIs in Chinese Medicine, e.g. polymorphism, cocrystals;
  • Development of time- and/or site-controlled delivery systems by fluidized bed technology;
  • TCM product development

We are looking for Master and PhD students, research assistants/postdoctoral fellows who are interested to join our research group. If you could meet the requirement of “Advanced Education European Asiatic Exchange Programme in Materials Science and Catalysis (EurasiaCat)”, please apply online at https://sites.google.com/site/emeurasiacat/call for the scholarship (the deadline is 15 Feb. 2015).
For further information, please contact Dr. Zheng at yzheng@umac.mo


Selected Publications

 

Papers in English:


Papers in English

    1. Yang X, Miao XQ, Cao FR, Li S, Ai NN, Chang Q, Simon Lee, Zheng Y*. Nanosuspension Development of Scutellarein as an Active and Rapid Orally Absorbed Precursor of its BCS Class IV Glycoside Scutellarin. Journal of Pharmaceutical Sciences 2014 Sep 3. doi: 10.1002/jps.24149.
    2. You C, Liang XD, Sun JB, Sun L, Wang YT, Fan TY, Zheng Y*. Blends of Hydrophobic and Swelling Agents in the Swelling Layer in the Preparation of Delayed-release Pellets of a Hydrophilic Drug with Low MW: Physicochemical Characterizations and In-vivo Evaluations. Asian Journal of Pharmaceutical Sciences.9:199-207, 2014.
    3. Song J, Wang YC, Song YL, Chan HM, Bi C, Yang X, Yan R, Wang YT and Zheng Y*. Development and Characterizations of Nanocrystals without Stabilizer of Ursolic Acid with Improved Dissolution Rate and In-vitro Anticancer Activity. AAPS PharmSciTech 15(1): 11-19 (2014).
    4. Zheng Y. Editorial: Novel Formulation Strategies for Poorly Water-soluble Drugs and Herbal Medicines. Current Pharmaceutical Design 20(3):301-2 (2014).
    5. Wang YC, Miao XQ, Sun L, Song J, Bi C, Yang X, Zheng Y*. Effects of nanosuspension formulations on transport, pharmacokinetics, in vivo targeting and efficacy for poorly water-soluble drugs. (Invited review article). Current Pharmaceutical Design 20(3): 454-473 (2014).
    6. Wang Y, Zheng Y, Zhang L, Wang Q, Zhang D. Stability of nanosuspensions in drug delivery. J Control Release. 172(3):1126-41(2013).
    7. Sun JB, Bi C, Chan HM, Sun SP, Zhang QW and Zheng Y*. Curcumin-loaded solid lipid nanoparticles have prolonged in-vitro antitumour activity, cellular uptake and improved in-vivo bioavailability. Colloids and Surfaces B: Biointerfaces 111:367-375 (2013).
    8. Li Y, Sun SP, Chang Q, Zhang L, Wang GN, Chen WX, Miao XQ, Zheng Y*. A strategy for the improvement of the bioavailability and anti-osteoporosis activity of BCS IV flavonoid glycosides through the formulation of their lipophilic aglycone into nanocrystals. Molecular Pharmaceutics 10: 2534-2542 (2013).
    9. Wang YC, Ma YY, Zheng Y, Song J, Yang X, Bi C, Zhang DR, Zhang Q. In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. Int. J. Pharm. 441(1-2): 728-735 (2013).
    10. Chang Q, Wang GN, Li Y, Zhang L, You C, Zheng Y*. Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii, in Rats. Phytomedicine 2012, 19(11): 1024-1028.
    11. Gong J, Chen M, Zheng Y, Wang S, Wang Y. Polymeric micelles drug delivery system in oncology. J Control Release. 2012, 159(3):312-23.
    12. Zhang XR, Zheng Y, Jin T, Chow AH. Formulation of sustained-release microspheres of granulocyte macrophage colony stimulating factor by freezing-induced phase separation with dextran and encapsulation with blended polymers. J Microencapsul. 2011, 28(8): 743-751.
    13. Wang CG, Sun JB, Wang JC, Zhang Q and Zheng Y*. LC Determination of Icariside II in Rat Plasma and Tissues: Application to a Tissue Distribution Study. Chromatographia. 2011, 74: 251-258.
    14. Wang YZ, Ao HS, Qian ZM, and Zheng Y*. Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin. Xenobiotica. 2011, 41(7): 538-548.
    15. Tong HY, Du Z, Wang GN, Chan HM, Chang Q, Lai CM, Chow AHL*, Zheng Y*. Spray freeze drying with polyvinylpyrrolidone and sodium caprate for improved dissolution and oral bioavailability of oleanolic acid, a BCS Class IV compound. Int. J. Pharm. 2011, 404(1-2): 148-158.
    16. He XQ, Pei LX, Tong HY, Zheng Y*. Comparison of Spray Freeze Drying and the Solvent Evaporation Method for Preparing Solid Dispersions of Baicalein with Pluronic F68 to Improve Dissolution and Oral Bioavailability. AAPS PharmSciTech., 2011, 12(1): 104-113.
    17. Tong HY, Chan HM, Du Z, Zheng Y. Evaluation of extemporaneous oral itraconazole suspensions by dissolution profiles mapping. Int. J. Pharm. Comp. 2010, 14(4): 342-345.
    18. Liang QY, Chow AHL, Wang YT, Tong HY*, Zheng Y*. Removal of Toxic Aristolochic Acid Components from Aristolochia Plants by Supercritical Fluid Extraction. Separation and Purification Technology. 2010, 72(3), 269-274.
    19. Zhao Y, Wang CG, Chow AHL, Ren K, Gong T, Zhang ZR, Zheng Y*. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies. Int. J. Pharm. 2010, 383: 170-177.
    20. Xi J, Chang Q, Chan CK, Meng ZY, Wang GN, Sun JB, Wang YT, Tong HY*, Zheng Y*. Formulation Development and Bioavailability Evaluation of a Self-Nanoemulsified Drug Delivery System of Oleanolic Acid. AAPS PharmSciTech. 2009, 10(1):172-182.
    21. Zheng Y, Chow AHL, Haworth, IS. Molecular Modeling of Flavonoid-beta-Cyclodextrin Complexes, Letters in Drug Design & Discovery. 2008, 5(8):512-520.
    22. Zheng Y, Chow AHL. Production and Characterization of a Spray-Dried Hydroxypropyl-beta-cyclodextrin/Quercetin Complex. Drug Dev. Ind. Pharm. 2008, 35(6): 727-734.
    23. Tong HY, Wu HB, Zheng Y, Xi J, Chow AHL, Chan CK. Physical characterization of oleanolic acid nonsolvate and solvates prepared by solvent Recrystallization. Int. J. Pharm. 2008, 355(1-2):195-202.
    24. Sa F, Gao JL, Fung KP, Zheng Y*, Lee SM, Wang YT. Anti-proliferative and Pro-apoptotic Effect of Smilax glabra Roxb. Extract on Hepatoma Cell Lines. Chemico-Biological Interactions . 2008, 171(1):1-14.
    25. Zheng Y, Zuo, Z and Chow AHL. Lack of effect of beta-cyclodextrin and its water-soluble derivatives on in vitro drug transport across rat intestinal epithelium, Int. J. Pharm. 2006, 309:123-128.
    26. Zheng, Y., Haworth, I. S., Zuo, Z., Chow, M. S. S. and Chow, A. H. L. Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes, J. Pharm. Sci., 94, 1079-1089 (2005).
    27. Zhang L, Zheng Y, Chow MSS, Zuo Z. Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. Int. J. Pharm., 287:1-12 (2004).

Papers in Chinese:

  1. 畢超,王言才,陳修平,鄭穎*. 薑黃素納米混懸液的抗癌活性及細胞攝取研究. 中藥新藥與臨床藥理. 2013, 24(4): 416-420.
  2. 王焱,鄭穎,宋小玲,陳銀芳,王金錢,王躍生.龍膽總苷胃漂浮微丸製備及其體外釋藥特性研究. 2012, 中草藥, 43(9): 1751-1755.
  3. 黃莉婷,孫少平,鄭穎*.生地黃中梓醇和毛蕊花糖苷的HPLC測定及提取工藝優化. 中藥材. 2012, 35(8): 1318-1322.
  4. 陳學文,宋菊,唐海誼,鄭穎*.藥物共晶篩選與理化性質研究進展. 中國醫藥工業雜誌.2012, 43(8): 703-708.
  5. 張燁,杜禎,孫少平,黎暢明,唐海誼,鄭穎*. 噴霧冷凍乾燥法製備丹參酮ⅡA固體分散體及其理化性質評價. 中國藥學雜誌. 2012, 47(3): 204-208.
  6. 李妍, 孫少平, 鄭穎*.通過高效液相色譜保留時間測定淫羊藿次苷-Ⅱ與苷元的油水分配係數. 中國藥學雜誌.  2012, 47(2): 122-126.
  7. 遊暢, 孫葭北, 孫少平, 鄭穎*.高效液相色譜法研究比格犬口服丹參素的藥代動力學. 中藥新藥與臨床藥理,2011, 22(3): 310-314.
  8. 熊秀莉, 穎*, 王一濤. 輔料聯用固體分散技術在丹參提取物多組分釋放中的應用. 中草藥, 2011, 42(1): 50-55.
  9. 何秀瓊,裴利霞,王一濤,鄭穎*.高效液相色譜法研究大鼠灌胃黃芩素的藥動學.中國醫院藥學雜誌, 2010, 30(22): 1901-1905.
  10. 梁雪丹,鄭穎*,范田園. 丹參酮ⅡA脈衝微丸的製備與體外質量評價. 北京大學學報(醫學版)2010,42(5):559-564.
  11. 王亞之,歐喜笑,鄭穎*. 外排轉運體和代謝酶與黃酮的相互作用及其對黃酮腸吸收影響的研究進展. 中草藥. 2009,40(10):1659-1663.
  12. 張燁,鄭穎*,王一濤. 應用改進的質量評價方法考察複方丹參製劑. 中成藥. 2009,31(12):1855-1860.
  13. 徐樹明,楊明 ,梁雪丹,王一濤,鄭穎*. 苦參堿時控型結腸定位給藥微丸的製備和體外釋藥研究. 中國藥學雜誌. 2009,44(22):1713-1718.
  14. 杜禎,鄭穎,黎暢明,王一濤,唐海誼. 噴霧冷凍乾燥技術進展及其在藥劑學中的應用. 中國藥學雜誌. 2009,44(10):724-727.
  15. 席佳,唐海誼,鄭穎*. 齊墩果酸口服製劑及其體內藥動學研究進展. 中國新藥雜誌. 2009,18(6):507-510.
  16. 趙一,何小強,席佳,任科,龔濤,王一濤,鄭穎*. 當歸揮發油中Z-葉本內酯的分離純化及其製劑的穩定性. 華西藥學雜誌. 2008,23(5):533-535.
  17. 梁雪丹,范田園,鄭穎*. 以丹參素為指標成份的丹參製劑及其藥動學研究概況. 中國新藥雜誌. 2008,17(21):1838-1842.
  18. 冷薇,鄭穎*,楊豐慶,李紹平,王一濤. 莪術油在Caco-2細胞模型中的吸收機制研究. 中國藥學雜誌. 2007,42(16):1228-1232.
  19. 梁慶優,鄭穎*,唐海誼,李紹平,王一濤. HPLC法測定靜態加壓溶劑提取馬兜鈴屬植物中馬兜鈴酸. 中草藥. 2007,39:364-368.
  20. 董曉兵,李軍,鄭穎,董婷霞,詹華強. 遠志皂苷對照品細葉遠志皂苷的製備. 中藥新藥與臨床藥理. 2007, 18:53-54

Book chapter

Zhou J, Liao YH, Zheng Y. Inhaled traditional Chinese medicine for respiratory diseases.
e-book: Frontiers in pulmonary drug delivery (in press).

Chow, AHL, Tong, HY, & Zheng, Y. (06/2007). Stability Assessment and Formulation Characterization, In Shayne C. Gad (Ed). Handbook of Pharmaceutical Biotechnology. (pp. 371-416). USA: John Wiley & Sons.

Chinese Patent

  1. 梁雪丹, 鄭穎, 范田園, 王一濤. 口服遲釋藥物製劑, 中國專利, 專利號ZL 200910130405.6.
  2. 唐海誼, 杜禎, 黎暢明, 鄭穎. 一體化噴霧冷凍乾燥設備及方法, 中國專利,專利號ZL 2008 1 0189058.X.

Ongoing research Project

  • 澳門特別行政區科技發展基金資助"中藥有效成分納米混懸給藥系統的研究"(2011/2014).
  • 澳門大學科研基金”Novel Nanoparticle Development of Active Components in Herbal Medicines and Their Permeations Across Blood-Brain Barrier on Cell Monolayers, Zebrafish and Rat Models” (2013-2016).
  • 澳門大學科研基金” Development of  Novel Targeted  Nanoparticles with Immunosuppressive Chinese  Medicine to Inhibit Skin Immune-response for Topical Therapy of Psoriasis” (2014-2017).

 

Award

  • Wang Lu et al., “Development of sustained-release PLGA nanoparticles with enhanced encapsulation efficiency loaded with dihydroartemisinin-phospholipid complex for cancer therapy” ,13th CGCM Meeting, 27-29 Aug., 2014, Beijing (travel grant award).
  • Yang Xiao et al., Nanosuspension Development of Scutellarein – a Prodrug of Scutellarin for Oral Delivery. Poster presentation at the 2013 AAPS@China Symposium, 17-18th Aug., 2013, Hong Kong (Poster presentation award).
  • Song Ju et al., Preparation and in-vitro Anticancer Activity Evaluations of Ursolic Acid Nanosuspensions with Different Particles Size. Poster presentation at the 2013 AAPS@China Symposium, 17-18th Aug., 2013, Hong Kong (Poster presentation award).

Community Services

  • Editorial board member of Asian Journal of Pharmaceutical Science

  • 中國顆粒學會-生物顆粒專委會委員 , 青年理事

  • Guest Editor in Current Pharmaceutical Design for the theme issue of  “Novel Formulation Strategies for Poorly Water-soluble Drugs and Herbal Medicines”

  • Add-hoc reviewers of several international referred journals: J. Pharm. Sci.; Colloids and Surfaces B: Biointerfaces; International Journal of Pharmaceutics; Journal of Pharmacy and Pharmacology; AAPS PharmSciTech; Drug Development and Industrial Pharmacy; Acta Pharmacologica Sinica; J. Microencapsulation; Chinese Pharmaceutical Journal     
 

Contact Details

Institute of Chinese Medical Sciences
University of Macau
Macao, China
Room 6010, 6/F, N22
Telephone: (853) 8822-4687
Fax: (853) 28841358
E-mail address: yzheng@umac.mo