Ying ZHENG  鄭穎

副教授


 

學歷 | 主講科目 |學術研究| 科研論著 |聯絡方法


學歷

  • 北京大學醫學部藥學院本科
  • 香港中文大學藥劑學院碩士
  • 香港中文大學藥劑學院博士

主講科目

博士科目: Pharmaceutical Engineering and Biomaterials Science

碩士科目 : Pharmaceutical Technology


學術研究

研究方向

  • 難溶性中草藥成分的製劑研究,如微乳,納米晶體,低溫製備固體分散體;
  • 晶體工程技術在中草藥活性成分上的應用, 如藥物共晶;
  • 通過流化床包衣技術製備定時/定位釋放的多微粒中藥釋藥系統;
  • 中草藥製劑研究及產品開發;

科研論著

代表作(中文)

  1. 畢超,王言才,陳修平,鄭穎*. 薑黃素納米混懸液的抗癌活性及細胞攝取研究. 中藥新藥與臨床藥理.2013, 24(4): 416-420.
  1. 陳學文,宋菊,唐海誼,鄭穎*.藥物共晶篩選與理化性質研究進展. 中國醫藥工業雜誌.2012, 43(8): 703-708.
  2. 張燁,杜禎,孫少平,黎暢明,唐海誼,鄭穎*. 噴霧冷凍乾燥法製備丹參酮ⅡA固體分散體及其理化性質評價. 中國藥學雜誌. 2012, 47(3): 204-208.
  3. 李妍, 孫少平, 鄭穎*.通過高效液相色譜保留時間測定淫羊藿次?-Ⅱ與?元的油水分配係數. 中國藥學雜誌.? 2012, 47(2): 122-126.
  4. 遊暢, 孫葭北, 孫少平, 鄭穎*.高效液相色譜法研究比格犬口服丹參素的藥代動力學. 中藥新藥與臨床藥理,2011, 22(3): 310-314.
  5. 熊秀莉, 穎*, 王一濤. 輔料聯用固體分散技術在丹參提取物多組分釋放中的應用. 中草藥, 2011, 42(1): 50-55.
  6. 何秀瓊,裴利霞,王一濤,鄭穎*.高效液相色譜法研究大鼠灌胃黃芩素的藥動學.中國醫院藥學雜誌, 2010, 30(22): 1901-1905.
  7. 梁雪丹,鄭穎*,范田園. 丹參酮ⅡA脈衝微丸的製備與體外質量評價. 北京大學學報(醫學版)2010,42(5):559-564.
  8. 王亞之,歐喜笑,鄭穎*. 外排轉運體和代謝?與黃酮的相互作用及其對黃酮腸吸收影響的研究進展. 中草藥. 2009,40(10):1659-1663.
  9. 張燁,鄭穎*,王一濤. 應用改進的質量評價方法考察複方丹參製劑. 中成藥. 2009,31(12):1855-1860.
  10. 徐樹明,楊明 ,梁雪丹,王一濤,鄭穎*. 苦參堿時控型結腸定位給藥微丸的製備和體外釋藥研究. 中國藥學雜誌. 2009,44(22):1713-1718.
  11. 杜禎,鄭穎,黎暢明,王一濤,唐海誼. 噴霧冷凍乾燥技術進展及其在藥劑學中的應用. 中國藥學雜誌. 2009,44(10):724-727.
  12. 席佳,唐海誼,鄭穎*. 齊墩果酸口服製劑及其體內藥動學研究進展. 中國新藥雜誌. 2009,18(6):507-510.
  13. 趙一,何小強,席佳,任科,龔濤,王一濤,鄭穎*. 當歸揮發油中Z-葉本內酯的分離純化及其製劑的穩定性. 華西藥學雜誌. 2008,23(5):533-535.
  14. 梁雪丹,范田園,鄭穎*. 以丹參素為指標成份的丹參製劑及其藥動學研究概況. 中國新藥雜誌. 2008,17(21):1838-1842.
  15. 冷薇,鄭穎*,楊豐慶,李紹平,王一濤. 莪術油在Caco-2細胞模型中的吸收機制研究. 中國藥學雜誌. 2007,42(16):1228-1232.
  16. 梁慶優,鄭穎*,唐海誼,李紹平,王一濤. HPLC法測定靜態加壓溶劑提取馬兜鈴屬植物中馬兜鈴酸. 中草藥. 2007,39:364-368.
  17. 董曉兵,李軍,鄭穎,董婷霞,詹華強. 遠志皂?對照品細葉遠志皂?的製備. 中藥新藥與臨床藥理. 2007, 18:53-54.

 

代表作(英文)  

  1. Yang X, Miao XQ, Cao FR, Li S, Ai NN, Chang Q, Simon Lee, Zheng Y*. Nanosuspension Development of Scutellarein as an Active and Rapid Orally Absorbed Precursor of its BCS Class IV Glycoside Scutellarin. Journal of Pharmaceutical Sciences 2014 Sep 3. doi: 10.1002/jps.24149.
  2. You C, Liang XD, Sun JB, Sun L, Wang YT, Fan TY, Zheng Y*. Blends of Hydrophobic and Swelling Agents in the Swelling Layer in the Preparation of Delayed-release Pellets of a Hydrophilic Drug with Low MW: Physicochemical Characterizations and In-vivo Evaluations. Asian Journal of Pharmaceutical Sciences.9:199-207, 2014.
  3. Song J, Wang YC, Song YL, Chan HM, Bi C, Yang X, Yan R, Wang YT and Zheng Y*. Development and Characterizations of Nanocrystals without Stabilizer of Ursolic Acid with Improved Dissolution Rate and In-vitro Anticancer Activity. AAPS PharmSciTech 15(1): 11-19 (2014).
  4. Zheng Y. Editorial: Novel Formulation Strategies for Poorly Water-soluble Drugs and Herbal Medicines. Current Pharmaceutical Design 20(3):301-2 (2014).
  5. Wang YC, Miao XQ, Sun L, Song J, Bi C, Yang X, Zheng Y*. Effects of nanosuspension formulations on transport, pharmacokinetics, in vivo targeting and efficacy for poorly water-soluble drugs. (Invited review article). Current Pharmaceutical Design 20(3): 454-473 (2014).
  6. Wang Y, Zheng Y, Zhang L, Wang Q, Zhang D. Stability of nanosuspensions in drug delivery. J Control Release. 172(3):1126-41(2013).
  7. Sun JB, Bi C, Chan HM, Sun SP, Zhang QW and Zheng Y*. Curcumin-loaded solid lipid nanoparticles have prolonged in-vitro antitumour activity, cellular uptake and improved in-vivo bioavailability. Colloids and Surfaces B: Biointerfaces 111:367-375 (2013).
  8. Li Y, Sun SP, Chang Q, Zhang L, Wang GN, Chen WX, Miao XQ, Zheng Y*. A strategy for the improvement of the bioavailability and anti-osteoporosis activity of BCS IV flavonoid glycosides through the formulation of their lipophilic aglycone into nanocrystals. Molecular Pharmaceutics 10: 2534-2542 (2013).
  9. Wang YC, Ma YY, Zheng Y, Song J, Yang X, Bi C, Zhang DR, Zhang Q. In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. Int. J. Pharm. 441(1-2): 728-735 (2013).
  10. Chang Q, Wang GN, Li Y, Zhang L, You C, Zheng Y*. Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii, in Rats. Phytomedicine 2012, 19(11): 1024-1028.
  11. Gong J, Chen M, Zheng Y, Wang S, Wang Y. Polymeric micelles drug delivery system in oncology. J Control Release. 2012, 159(3):312-23.
  12. Zhang XR, Zheng Y, Jin T, Chow AH. Formulation of sustained-release microspheres of granulocyte macrophage colony stimulating factor by freezing-induced phase separation with dextran and encapsulation with blended polymers. J Microencapsul. 2011, 28(8): 743-751.
  13. Wang CG, Sun JB, Wang JC, Zhang Q and Zheng Y*. LC Determination of Icariside II in Rat Plasma and Tissues: Application to a Tissue Distribution Study. Chromatographia. 2011, 74: 251-258.
  14. Wang YZ, Ao HS, Qian ZM, and Zheng Y*. Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin. Xenobiotica. 2011, 41(7): 538-548.
  15. Tong HY, Du Z, Wang GN, Chan HM, Chang Q, Lai CM, Chow AHL*, Zheng Y*. Spray freeze drying with polyvinylpyrrolidone and sodium caprate for improved dissolution and oral bioavailability of oleanolic acid, a BCS Class IV compound. Int. J. Pharm. 2011, 404(1-2): 148-158.
  16. He XQ, Pei LX, Tong HY, Zheng Y*. Comparison of Spray Freeze Drying and the Solvent Evaporation Method for Preparing Solid Dispersions of Baicalein with Pluronic F68 to Improve Dissolution and Oral Bioavailability. AAPS PharmSciTech., 2011, 12(1): 104-113.
  17. Tong HY, Chan HM, Du Z, Zheng Y. Evaluation of extemporaneous oral itraconazole suspensions by dissolution profiles mapping. Int. J. Pharm. Comp. 2010, 14(4): 342-345.
  18. Liang QY, Chow AHL, Wang YT, Tong HY*, Zheng Y*. Removal of Toxic Aristolochic Acid Components from Aristolochia Plants by Supercritical Fluid Extraction. Separation and Purification Technology. 2010, 72(3), 269-274.
  19. Zhao Y, Wang CG, Chow AHL, Ren K, Gong T, Zhang ZR, Zheng Y*. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies. Int. J. Pharm. 2010, 383: 170-177.
  20. Xi J, Chang Q, Chan CK, Meng ZY, Wang GN, Sun JB, Wang YT, Tong HY*, Zheng Y*. Formulation Development and Bioavailability Evaluation of a Self-Nanoemulsified Drug Delivery System of Oleanolic Acid. AAPS PharmSciTech. 2009, 10(1):172-182.
  21. Zheng Y, Chow AHL, Haworth, IS. Molecular Modeling of Flavonoid-beta-Cyclodextrin Complexes, Letters in Drug Design & Discovery. 2008, 5(8):512-520.
  22. Zheng Y, Chow AHL. Production and Characterization of a Spray-Dried Hydroxypropyl-beta-cyclodextrin/Quercetin Complex. Drug Dev. Ind. Pharm. 2008, 35(6): 727-734.
  23. Tong HY, Wu HB, Zheng Y, Xi J, Chow AHL, Chan CK. Physical characterization of oleanolic acid nonsolvate and solvates prepared by solvent Recrystallization. Int. J. Pharm. 2008, 355(1-2):195-202.
  24. Sa F, Gao JL, Fung KP, Zheng Y*, Lee SM, Wang YT. Anti-proliferative and Pro-apoptotic Effect of Smilax glabra Roxb. Extract on Hepatoma Cell Lines. Chemico-Biological Interactions . 2008, 171(1):1-14.
  25. Zheng Y, Zuo, Z and Chow AHL. Lack of effect of beta-cyclodextrin and its water-soluble derivatives on in vitro drug transport across rat intestinal epithelium, Int. J. Pharm. 2006, 309:123-128.
  26. Zheng, Y., Haworth, I. S., Zuo, Z., Chow, M. S. S. and Chow, A. H. L. Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes, J. Pharm. Sci., 94, 1079-1089 (2005).
  27. Zhang L, Zheng Y, Chow MSS, Zuo Z. Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. Int. J. Pharm., 287:1-12 (2004).  

書籍/章節

Zhou J, Liao YH, Zheng Y. Inhaled traditional Chinese medicine for respiratory diseases. e-book: Frontiers in pulmonary drug delivery (in press).

Chow, AHL, Tong, HY, & Zheng, Y. (06/2007). Stability Assessment and Formulation Characterization, In Shayne C. Gad (Ed). Handbook of Pharmaceutical Biotechnology. (pp. 371-416). USA: John Wiley & Sons.

專利
  1. 梁雪丹, 鄭穎, 范田園, 王一濤. 口服遲釋藥物製劑, 中國專利, 專利號ZL 200910130405.6.
  2. 唐海誼, 杜禎, 黎暢明, 鄭穎. 一體化噴霧冷凍乾燥設備及方法, 中國專利,專利號ZL 2008 1 0189058.X.  

研究項目

  • 澳門特別行政區科技發展基金資助"中藥有效成分納米混懸給藥系統的研究"(2011/2014).
  • 澳門大學科研基金”Novel Nanoparticle Development of Active Components in Herbal Medicines and Their Permeations Across Blood-Brain Barrier on Cell Monolayers, Zebrafish and Rat Models” (2013-2016).
  • 澳門大學科研基金” Development of Novel Targeted Nanoparticles with Immunosuppressive Chinese Medicine to Inhibit Skin Immune-response for Topical Therapy of Psoriasis” (2014-2017).  

獲獎

  • Wang Lu et al., “Development of sustained-release PLGA nanoparticles with enhanced encapsulation efficiency loaded with dihydroartemisinin-phospholipid complex for cancer therapy” ,13th CGCM Meeting, 27-29 Aug., 2014, Beijing (travel grant award).
  • Yang Xiao et al., Nanosuspension Development of Scutellarein – a Prodrug of Scutellarin for Oral Delivery. Poster presentation at the 2013 AAPS@China Symposium, 17-18th Aug., 2013, Hong Kong (Poster presentation award).
  • Song Ju et al., Preparation and in-vitro Anticancer Activity Evaluations of Ursolic Acid Nanosuspensions with Different Particles Size. Poster presentation at the 2013 AAPS@China Symposium, 17-18th Aug., 2013, Hong Kong (Poster presentation award).

社會服務


亞洲藥劑學雜誌編委

中國顆粒學會-生物顆粒專委會委員, 青年理事

執行編輯: Current Pharmaceutical Design,“Novel Formulation Strategies for Poorly Water-soluble Drugs and Herbal Medicines”

審稿人: J. Pharm. Sci.; Colloids and Surfaces B: Biointerfaces; International Journal of Pharmaceutics; Journal of Pharmacy and Pharmacology; AAPS PharmSciTech; Drug Development and Industrial Pharmacy; Acta Pharmacologica Sinica; J. Microencapsulation; Chinese Pharmaceutical Journal etc.


聯絡方法

澳門大學 中華醫藥研究院, 中國澳門
N22 座 6樓 6010室
電話 : (853) 8822-4687
傳真 : (853) 28841358
電子郵件: yzheng@umac.mo